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Breast cancer is an all too common disease in women, making how to effectively predict it an active research problem. A number of statistical and machine learning techniques have been employed to develop various breast cancer prediction models. Among them, support vector machines (SVM) have been shown to outperform many related techniques. To construct the SVM classifier, it is first necessary to decide the kernel function, and different kernel functions can result in different prediction performance. However, there have been very few studies focused on examining the prediction performances of SVM based on different kernel functions. Moreover, it is unknown whether SVM classifier ensembles which have been proposed to improve the performance of single classifiers can outperform single SVM classifiers in terms of breast cancer prediction. Therefore, the aim of this paper is to fully assess the prediction performance of SVM and SVM ensembles over small and large scale breast cancer datasets. The classification accuracy, ROC, F-measure, and computational times of training SVM and SVM ensembles are compared. The experimental results show that linear kernel based SVM ensembles based on the bagging method and RBF kernel based SVM ensembles with the boosting method can be the better choices for a small scale dataset, where feature selection should be performed in the data pre-processing stage. For a large scale dataset, RBF kernel based SVM ensembles based on boosting perform better than the other classifiers.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217832 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161501 | PLOS |
Injury
August 2025
Department of Orthopaedics, Peking University Third Hospital, Beijing, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, China. Electronic address:
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J Ethnopharmacol
September 2025
School of Public Health and Laboratory Medicine, Hunan University of Medicine, Huaihua, 418000, Hunan, China. Electronic address:
Objective: This study aimed to integrate network pharmacology, bioinformatics analysis, molecular docking, and experimental validation to construct a "component-target-pathway" multidimensional network model, systematically elucidate the potential mechanisms underlying the therapeutic effects of the extract of Potentilla freyniana Bornm. (PFB) on hepatocellular carcinoma (HCC), and thereby clarify its pharmacological basis.
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Int Immunopharmacol
September 2025
The First Affiliated Hospital, Zhejiang University School of Medicine, 1367 West Wenyi Rd., Yuhang District, Hangzhou, Zhejiang Province, China. Electronic address:
Macrophages, pivotal orchestrators of the immune system, are integral to the initiation of specific immune responses and exert profound influence on the pathogenesis, progression, and therapeutic landscape of aortic dissection (AD). Leveraging the precision of single-cell RNA sequencing (scRNA-seq), this study aimed to dissect the heterogeneity of macrophages within the AD microenvironment. We identified a unique macrophage subpopulation, termed AD-associated macrophages (AD-mac), which is predominantly implicated in the early stages of AD pathogenesis.
View Article and Find Full Text PDFTechnol Cancer Res Treat
September 2025
Department of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
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View Article and Find Full Text PDFACS Omega
August 2025
School of Energy and Environment, Anhui University of Technology, Maanshan 243002, China.
Accurate assessment of coal quality is essential for optimizing combustion efficiency and reducing pollutant emissions in coal-fired power plants. In this study, we developed a laser-induced breakdown spectroscopy (LIBS)-based framework, combined with advanced machine learning techniques to predict key coal quality parameters, including elemental carbon, ash content, volatile matter, total sulfur, and calorific value. After applying spectral preprocessing methods.
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