Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The biogenetic origin of triterpene dimers from the Celastraceae family has been proposed as assisted hetero-Diels-Alder reaction (HDA). In this work, computational calculation of HDA between natural quinonemethides (tingenone and isopristimerol) and hypothetical orthoquinones has been performed at the M06-2X/6-31G(d) level of theory. We have located all the HDA transition states supporting the biogenetic route via HDA cycloadditions. We found that all reactions take place through a concerted inverse electron demand and asynchronous mechanism. The enzymatic assistance for dimer formation was analyzed in terms of the calculated transition state energy barrier.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273858 | PMC |
| http://dx.doi.org/10.3390/molecules21111551 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Undescribed Phyllocladane-Type Diterpenoids from Hesse ex Rehd. and Their Anti-Neuroinflammatory Activity.
Molecules
March 2025
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Hesse ex Rehd. is an endemic plant in China and has long been used as a traditional medicine in several provinces. Although the plant has been reported to contain flavonoids, triterpenes, and alkaloids, this study represents the first report of the isolation of phyllocladane-type diterpenoids, a relatively rare class of compounds.
View Article and Find Full Text PDF20(S)-ginsenoside Rg3 suppresses gastric cancer cell proliferation by inhibiting E2F-DP dimerization.
Phytomedicine
June 2025
School of Life Sciences, Jilin University, 2699 Qianjin Street, Chaoyang District, Changchun, Jilin 130012, China. Electronic address:
Background: Gastric cancer (GC) is a common and aggressive malignancy, with treatment options often limited by drug resistance and the adverse effects of targeted therapies and immunotherapy. Ginsenoside Rg3, a bioactive compound derived from ginseng, has shown promise in inhibiting the growth of various tumor types, including GC. However, the molecular mechanisms underlying its therapeutic effects against GC remain insufficiently understood.
View Article and Find Full Text PDFPhytochemical and pharmacological properties of the genus Pseudotsuga.
Fitoterapia
June 2025
Department of Pharmacy, College of Medicine, Jiaxing University, Jiaxing 314001, China.
Pseudotsuga is a crucial genus of timber trees in the Pinaceae family, comprising approximately 18 species that are predominantly found in western North America and East Asia. Over the past several decades, scholarly attention has primarily focused on the phytochemical study of Pseudotsuga menziesii, revealing a diverse range of compounds, including monoterpenes, sesquiterpenes, and flavonoids. Notably, recent advancements have also identified rare triterpene-monoterpene and triterpene-diterpene adducts, as well as triterpenoid dimers, from the Pseudotsuga genus.
View Article and Find Full Text PDFIsolation of a Unique Monoterpene Diperoxy Dimer From Ziziphora clinopodioides subsp. bungeana Together With Triterpenes With Antidiabetic Properties.
Phytochem Anal
June 2025
Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic.
Introduction: Ziziphora clinopodioides subsp. bungeana (Juz.) Rech.
View Article and Find Full Text PDFPhytometabolites, Pharmacological Effects, Ethnomedicinal Properties, and Bioeconomic Potential of Velvet Apple (Diospyros discolor Willd.): A Review.
Chem Biodivers
May 2025
Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
Diospyros discolor Willd., commonly known as velvet apple or Mabolo, is an underutilized fruit. Traditionally, various parts of D.
View Article and Find Full Text PDF