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Article Abstract
Objective: To evaluate cluster of differentiation (CD)127 expression in T cells of patients with HIV-1 and the relationship of CD127 expression with disease progression.
Methods: We divided 139 patients infected with human immunodeficiency virus type 1 (HIV-1) who had undergone highly active antiretroviral therapy (HAART) into 3 groups: patients with poor recovery (CD4T < 350/μ;L, patients with general recovery (CD4T = 350 - ∼600/μL) and patients with good recovery (CD4T > 600/μL). Counts and percentages of naïve (CD45RA) and memory (CD45RO) T cells and CD127 expression were determined using flow cytometry.
Results: CD4CD45RO, CD4CD45RA, CD4 CD45RO CD127, and CD4CD45RACD127T-cell counts in patients with good recovery were higher than in patients with poor recovery and those with general recovery patients (P <.05). Percentages of CD45RO were increased, and percentages of CD45RA and CD127 in T cells were decreased in patients with poor and general recovery (P <.05). CD127 values were positively correlated with CD4T-cell counts and percentages of CD45RA subsets (P <.05).
Conclusion: CD127 expression in T cells is decreased in patients with HIV-1 and is related to recovery of CD4T-cell counts and to naïve subsets.
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| http://dx.doi.org/10.1093/labmed/lmw053 | DOI Listing |
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