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http://dx.doi.org/10.1016/j.ijcard.2016.08.020 | DOI Listing |
Metab Brain Dis
September 2025
Department of Neuroscience, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Brain ischemia is a major global cause of disability, frequently leading to psychoneurological issues. This study investigates the effects of 4-aminopyridine (4-AP) on anxiety, cognitive impairment, and potential underlying mechanisms in a mouse model of medial prefrontal cortex (mPFC) ischemia. Mice with mPFC ischemia were treated with normal saline (NS) or different doses of 4-AP (250, 500, and 1000 µg/kg) for 14 consecutive days.
View Article and Find Full Text PDFHandb Exp Pharmacol
September 2025
National Institute of Biological Sciences, Beijing, China.
G protein-coupled receptors (GPCRs) engage multiple transducers to regulate distinct physiological processes. These transducers include various G proteins subtypes, GPCR kinases (GRKs), and β-arrestins. In addition to promoting receptor desensitization, β-arrestins serve as scaffolds for signaling via non-G protein pathways.
View Article and Find Full Text PDFMol Biol Rep
September 2025
Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
Neuroinflammation, a vital protective response for tissue homeostasis, becomes a detrimental force when chronic and dysregulated, driving neurological disorders like Alzheimer's, Parkinson's, and Huntington's diseases. Potassium (K) channels maintain membrane potential and cellular excitability in neurons and glia within the intricate CNS signaling network. Neuronal injury or inflammation can disrupt K channel activity, leading to hyperexcitability and chronic pain.
View Article and Find Full Text PDFChem Commun (Camb)
September 2025
Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China.
In this work, a series of potassium ion (K) pre-intercalated sodium hydrogen vanadates (K-HNVO) are prepared through a facile route. The introduction of K modulates the microstructure of the pristine sodium metavanadate and increases the interlayer spacing, thereby resulting in improved charge transport kinetics. Moreover, the pillaring effect of K enhances the structural stability of the pristine material.
View Article and Find Full Text PDFPhotosynth Res
September 2025
College of Life Sciences, Shanghai Normal University, Shanghai, 200235, China.
Euglena sanguinea (Ehrenberg 1831) is one of the earliest reported species within the genus Euglena. Its prolific proliferation leading to red algal bloom has garnered significant scientific attention due to its ecological and environmental impacts. Despite this, research on E.
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