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We examine the dynamics of substance use and psychiatric symptoms from childhood to adolescence using a longitudinal study of Mexican-origin families (N = 674). We present a longitudinal model capturing the trajectories of substance use and psychiatric symptoms (depression, conduct disorder), as well as the interrelations between these trajectories over time. Such a model is an extension of latent change score models designed to account for the occurrence of psychiatric symptoms while also accommodating a large amount of zeros for nonoccurrence and characterizing the changes over time in the count data. We compare this model with a more traditional approach based on a log transformation of the data. We describe differences between these approaches and highlight the benefits of using the two-part model when the data include a large amount of zeros for nonoccurrence of the behavior.
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http://dx.doi.org/10.1080/00273171.2016.1144501 | DOI Listing |
Ann Palliat Med
September 2025
Department of Psycho-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Background: Delirium derived from dementia with Lewy bodies (DLB), and the risk of drug hypersensitivity derived from DLB is not well recognized in oncology. To avoid severe side effects caused by antipsychotics, these risks need to be carefully considered by health care providers involved in cancer treatment. The objective of this study is to report the presence of DLB-derived delirium, which is often mixed with ordinary delirium, and its associated hidden risk in cancer treatment.
View Article and Find Full Text PDFDev Psychobiol
September 2025
Department of Psychiatry, University of Illinois Chicago, Chicago, Illinois, USA.
Depressed mothers often experience parenting difficulties, which can persist after their symptoms have remitted. However, not all depressed mothers show parenting struggles, suggesting that there could be unidentified characteristics that increase risk. Specifically, neurobiological models emphasize that reward system deficits contribute to maladaptive parenting and depression, but no studies have evaluated how they could conjointly lead to parenting challenges.
View Article and Find Full Text PDFSchizophr Bull
September 2025
Department of Psychology, Faculty of Health & Life Sciences, University of Exeter, Exeter, EX4 4QG, United Kingdom.
Background And Hypothesis: The dysconnectivity hypothesis of schizophrenia suggests that atypical neural communication underlies the disorder's diverse symptoms. Building on this framework, we propose that specific synaptic disturbances within thalamo-cortical circuits contribute to an imbalance in excitation and inhibition, leading to alteration in oscillations. Our study investigates these alterations and explores whether synaptic restoration can remediate neural activity of schizophrenia and align it with healthy patterns.
View Article and Find Full Text PDFSchizophr Bull
September 2025
Department of Psychiatry, Central Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Background And Hypothesis: Schizophrenia is linked to hippocampal dysfunction and microglial inflammatory activation. Our prior clinical findings revealed significantly reduced transient receptor potential vanilloid 1 (TRPV1) expression in both first-episode and recurrent schizophrenia patients, with levels inversely correlating with symptom severity, implicating TRPV1 dysfunction in disease progression. Preclinical maternal separation (MS) models recapitulate schizophrenia-like behavioral and synaptic deficits, paralleled by hippocampal microglial TRPV1 downregulation.
View Article and Find Full Text PDFIntroduction: Injectable extended-release buprenorphine is an effective treatment for opioid use disorder (OUD), but injection site reactions (ISRs) are common treatment-emergent adverse events that may impact patient comfort, adherence, and outcome. This report examines the clinical presentation, prevalence, and management of Sublocade-related ISRs through two case studies and a review of existing literature.
Case Presentation: We present two cases of ISRs in patients receiving extended-release buprenorphine, Sublocade.