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Mutual cooperation in the formal allyl alcohol nucleophilic substitution reaction and hydration of an alkyne has been utilized in the presence of a gold catalyst to give a series of γ-functionalized ketones with high to excellent yields. This reaction actually involved an intramolecular O-H insertion cyclization of an alkyne to form the dihydrofuran intermediate, which was followed by the nucleophilic addition ring-opening of a dihydrofuran to give the target compound.
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http://dx.doi.org/10.1002/chem.201600248 | DOI Listing |
Int J Clin Oncol
September 2025
Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Background: Limited data are available on relative survival (RS) among cancer survivors enrolled in private cancer insurance in Japan. Additionally, the incidence of second primary cancers or recurrences, as applicable, after a certain period remains unclear.
Methods: We analyzed 8,846 cancer survivors, including carcinoma in situ, aged 15-79 years, enrolled in private cancer insurance between April 2005 and September 2021, and diagnosed before April 2022.
Eur J Health Econ
September 2025
Erasmus School of Health Policy & Management, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands.
Background: Policymakers face challenges in developing pricing policies for potentially innovative healthcare technologies (pIHTs) that balance limited budgets, access, and incentives for innovation. This study aimed to map existing evidence and identify knowledge gaps regarding price determinants and pricing policies for pIHTs and their effect on access and sustainability.
Methods: We conducted a scoping Review of scientific and grey literature in English published between 2014 and September 2023 with pre-specified inclusion and exclusion criteria to identify stakeholder-informed price determinants, pricing policies applied by European Economic Area (EEA) or Organisation for Economic Cooperation and Development (OECD) member states, and their access-related impacts.
J Phys Chem B
September 2025
School of Materials Science & Engineering, Shandong University of Technology, Zibo 255000, China.
The glass transition is dynamically heterogeneous with non-Arrhenius, nonexponential, and nonlinear features, and those parameters are mutually correlated in most cases. This study systematically investigates these interrelated features through thermodynamic analysis of polyvinylpyrrolidone (PVP)/salt complexes, employing enthalpy relaxation parameters, specifically the heat capacity jump (Δ) at and enthalpy hysteresis (Δ). Notably, the introduction of ionic interactions induces simultaneous reductions in dynamic fragility (), nonexponential parameter (β), and nonlinear parameter (), thereby disrupting their previously established empirical correlations.
View Article and Find Full Text PDFNephrology (Carlton)
September 2025
Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Aim: Sodium polystyrene sulfonate (SPS) is one of the classic potassium-binding agents that remains commonly used in the treatment of hyperkalaemia. However, the potential concern about its sodium load has not been fully investigated. In this study, we evaluated the association between SPS initiation and heart failure (HF), compared with calcium polystyrene sulfonate (CPS).
View Article and Find Full Text PDFPLoS One
September 2025
School of Computer and Information Engineering, Harbin University of Commerce, Harbin, China.
The breakthroughs in communication technologies, such as 5G, have significantly accelerated the popularity of high-traffic consumption entertainment activities, including short video live streaming and real-time broadcasting, making them one of the most prevalent social interaction methods today. It is the high activity level of such online engagements that has given rise to diversified online marketing business models, opening up new channels and opportunities for interactions between brands and consumers. This study focuses on the emerging "influencer marketing" strategy rooted in content marketing, employing double-layer network game theory to construct a dual-layer relationship network between "brands" and "influencers" and establish a game-theoretic mechanism between them.
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