98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1002/cncy.21703 | DOI Listing |
Biosens Bioelectron
September 2025
College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun, 130012, China. Electronic address:
Papillary thyroid carcinoma (PTC) is the most prevalent form of thyroid cancer with a high incidence among endocrine malignancies. It tends to metastasize early in lymph nodes and differs markedly from other subtypes in biological behavior, clinical management, and prognosis. Therefore, accurately distinguishing PTC from other pathological subtypes is crucial for guiding diagnosis and treatment decisions.
View Article and Find Full Text PDFEndocr Pathol
September 2025
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Although a diagnosis of anaplastic thyroid carcinoma (ATC) can be rendered on fine needle aspiration (FNA), a core needle biopsy is often performed to provide sufficient material for immunohistochemical and molecular analysis. Rendering an ATC diagnosis on core biopsy can be challenging due to limited material. It is crucial that other diagnostic entities in the differential, such as poorly differentiated thyroid carcinoma, medullary thyroid carcinoma, lymphoma, metastases, and NUT carcinoma (among others), are considered and that immunohistochemistry (IHC) is employed judiciously to support the diagnosis.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Ultrasound Diagnostic Center, The First Hospital of Jilin University, Changchun, China.
Objective: This study aims to construct a multimodal radiomics model based on contrast-enhanced ultrasound (CEUS) radiomic features, combined with conventional ultrasonography (US) images and clinical data, to evaluate its diagnostic efficacy in differentiating benign and malignant thyroid nodules (TNs) classified as C-TIRADS 4, and to assess the clinical application value of the model.
Methods: This retrospective study enrolled 135 patients with C-TIRADS 4 thyroid nodules who underwent concurrent US and CEUS before FNA/surgery. From each case, one US image and three CEUS key frames (2s post-perfusion, peak enhancement, 2s post-peak) were selected.
Ann Med Surg (Lond)
September 2025
Department of Interventional Radiology, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Background: Approximately 15% of fine-needle aspiration biopsy (FNAB) procedures are considered inconclusive, caused by various factors such as nodule characteristics, level of expertise, and needle size. Since needle size may play a crucial role in both adequacy of FNAB samples and reduction of complications, our objective was to compare cytology specimen adequacy, blood contamination, and findings in thyroid nodules and lymph nodes using 22- and 25-gauge needles in fine-needle aspiration (FNA).
Materials And Methods: A retrospective comparative cohort study was conducted at King Fahad Specialist Hospital, Saudi Arabia.
Cancer Cytopathol
September 2025
Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Background: Rapid on-site evaluation (ROSE) of thyroid fine-needle aspiration biopsy (FNAB) improves diagnostic adequacy and facilitates ancillary molecular testing. In this prospective, multireader study, the authors evaluated the feasibility of using whole-slide images (WSIs) for ROSE to determine specimen adequacy and preliminary categorization (according to The Bethesda System for Reporting Thyroid Cytopathology [Bethesda]) of image-guided thyroid FNABs compared with conventional light-microscopic (LM) examination of the same specimens in a referral cancer center.
Methods: The authors evaluated 98 ultrasound-guided thyroid FNAB cases.