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A rare bone tumor of 3rd metacarpal bone in a male child aged 2 years is being described. The patent presented with a gradually increasing, painful swelling over the dorsum of right hand which radiologically revealed an expansile, radioluscent mass, in 3rd metacarpal shaft with cortical destruction. The clinic-radiological differential diagnosis was aggressive cartilage tumor or an osteomyelitis. Histological examination of surgical biopsy material revealed randomly arranged woven bone lined by epithelioid osteoblast and after correlating the clinic-radiological features the diagnosis was an aggressive osteoblastoma. Appropriate diagnosis of such a rare tumor in an unusual location and age group facilitate adequate management by surgery alone without radiotherapy or chemotherapy.
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http://dx.doi.org/10.1016/j.jbo.2013.02.001 | DOI Listing |
Medicine (Baltimore)
August 2025
Faculty of Physiotherapy and Rehabilitation, Pamukkale University, Denizli, Türkiye.
Rationale: Aggressive osteoblastoma (AO) is an extremely rare cancer that mainly affects the spine and long bones and is less frequent in craniofacial bones. Cases involving the skull are even rarer, and the low incidence rates limit our understanding of the distribution and treatment strategies of AO. The aim of this study was to explore the clinical features, imaging findings, pathological characteristics, diagnoses, treatment, and prognosis of AO involving the skull.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of Neurosurgery, First Hospital of Jilin University, Changchun, China.
Rationale: Aggressive osteoblastoma (AO) is an extremely rare cancer that mainly affects the spine and long bones and is less frequent in craniofacial bones. Cases involving the skull are even rarer, and the low incidence rates limit our understanding of the distribution and treatment strategies of AO. The aim of this study was to explore the clinical features, imaging findings, pathological characteristics, diagnoses, treatment, and prognosis of AO involving the skull.
View Article and Find Full Text PDFSurg Pathol Clin
September 2025
Department of Anatomic Pathology, Cleveland Clinic, L25, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:
Primary tumors of bone encompass a wide array of lineages of differentiation, including osteogenic, chondrogenic, fibrogenic, vascular, hematopoietic, and notochordal, amongst other mesenchymal lineages of origin. Osteogenic neoplasms of bone are defined by tumor cell production of osteoid matrix and/or mature bone by the neoplastic cells themselves, encompassing the full biologic spectrum, ranging from benign to intermediate (locally aggressive or rarely metastasizing) and malignant entities. Herein we provide an updated overview focused on benign bone-forming tumors: osteoma, osteoid osteoma, osteoblastoma and variants, atypical sclerosing osteoblastic neoplasm, and both benign and malignant neoplasms within the differential diagnosis of these entities.
View Article and Find Full Text PDFSkeletal Radiol
October 2025
Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Osteoblastomas are rare, benign, bone-forming tumors, most commonly appearing in the axial skeleton. Osteoblastomas arising in the skull are even rarer and tend to originate in the temporal and frontal bones, with involvement of the sphenoid bone being one of the least common sites described. This report discusses a case of an aggressive appearing osteoblastoma of the sphenoid bone that was diagnosed via percutaneous biopsy.
View Article and Find Full Text PDFAm J Case Rep
March 2025
Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
BACKGROUND Tenosynovial giant cell tumor (TGCT) is a rare, benign, yet aggressive, lesion, usually involving a bursa or the tendon sheath. Spinal TGCT is quite rare. Its appearance on imaging can mimic other aggressive diseases, including giant cell tumor of bone, metastatic disease, and osteoblastoma, thus posing a diagnostic dilemma.
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