First-in-India Experience with 90Y-BhabhaSphere: An Indigenous 90Y-TheraSphere Biosimilar for Transarterial radioembolization of Hepatic Malignancies.

Objective: Primary and secondary hepatic malignancies are a significant cause of cancer-related mortality worldwide. Radioembolization with yttrium-90 (90Y) microspheres has emerged as a promising treatment option for unresectable hepatic tumors. However, the high cost of commercially available Y-90 microspheres, such as 90Y-TheraSphere or 90Y-SirSphere, limits their accessibility in developing countries.

Hypervalent Organotin(IV) Compounds as Efficient Catalysts for the Knoevenagel Condensation of Aldehydes.

We report the synthesis of six mononuclear organotin(IV) compounds, [RSn(L)] [R = Ph (1), t-Bu (2), and Me (3)] and [RSn(L)] [R = Ph (4), t-Bu (5), and Me (6)] supported by two polydentate pro-ligands, (E)-2,4-dichloro-6-(((2-hydroxy-5-nitrophenyl)imino)methyl)phenol (HL) and (E)-2,4-dichloro-6-(((2-hydroxyphenyl)imino)methyl)phenol (HL). HR-MS, multinuclear (H, C, and Sn) NMR spectroscopy, and FT-IR spectroscopy were used to characterize all compounds (1-6). Structural investigation via single-crystal X-ray diffraction confirmed a mononuclear geometry for all compounds, each featuring a five-coordinate tin(IV) center.

Subtle concentration changes in zinc hold the key to fibrillation of α-synuclein: an updated insight on the micronutrient's role in prevention of neurodegenerative disorders.

Misfolded proteins have been found to be at the core of an increasing number of cognitive ailments. α-synuclein, a resident chaperone of the neurosynaptic cleft has been implicated in a major share of these neurodegenerative diseases. Over the years, a daunting task for researchers has been the identification of the complex set of conditions which govern the Substantia nigra microenvironment for transformation of α-synuclein from a functional and grossly structureless chaperone to toxic cross-β fibrils.

A low-cost four-component relativistic coupled cluster linear response theory based on perturbation sensitive natural spinors.

We present an efficient implementation of four-component linear response coupled cluster singles and doubles (4c-LRCCSD) theory that enables accurate and computationally efficient calculation of polarizabilities for systems containing heavy elements. We have observed that the frozen natural spinor (FNS)-based truncation scheme is not suitable for linear response properties, as it leads to larger errors in static and dynamic polarizability values. In this work, we have introduced a "perturbation-sensitive" density to construct the natural spinor basis, termed FNS++.

Bioinspired Synthesis of Intrinsically Radiolabeled DyO Nanoparticles as an In Vivo Generator of Dy/Ho: A Smart Choice for Theranostics Engineering.

Functionalized inorganic nanoparticles (NPs) intrinsically radiolabeled with theranostic radiometals hold the potential to revolutionize cancer management. The appropriate choice of the radiometal used in the nanoplatform would not only aid in the diagnosis and staging of the disease but also facilitate them becoming an integral part of the therapeutic regimen, either as an independent treatment or in combination with other conventional modalities. Furthermore, due to the inherent characteristics of the NPs, such systems can demonstrate potential in multimodality imaging to offer improved diagnostic and therapeutic monitoring abilities for personalized treatment.

Synthesis and biological evaluation of naphthoquinone-fused pyrrole and imidazopyridinedione heterocycles.

We have developed an efficient and straightforward synthetic route to obtain naphthoquinone-fused pyrrole derivatives (up to 93% yield) an intramolecular cyclization of 2-(arylethynyl)naphthalene-1,4-dione derivatives with NHOAc in methanol at ambient temperature. Furthermore, imidazopyridinedione derivatives were synthesized coupling between 2-bromonaphthalene-1,4-dione and 2-amino pyridine through condensation and rearrangement under neat conditions in the presence of a catalytic amount of AcOH. A series of functionalized pyrrolonaphthoquinone and imidazopyridinedione derivatives were synthesized in high yields.

Solvent-free hydrosilylation of carbonyl compounds catalyzed by organotin(IV) compounds.

Four new organotin(IV) compounds, [RSn(L)] [R = Ph (1), Me (2), -Bu (3), and -Bu (4)], have been synthesized from a polydentate pro-ligand ()-2,4-dichloro-6-(((2-hydroxy-5-methylphenyl)imino)methyl)phenol (H2L). Organotin(IV) halides such as PhSnCl, MeSnCl, (-Bu)SnCl, and (-Bu)SnCl were reacted with the pro-ligand using EtN as a base to form compounds 1-4. FT-IR spectroscopy, H, C{H}, Sn{H} NMR spectroscopy, HR-MS, and single-crystal X-ray diffraction studies were used to characterize all these newly synthesized compounds.

Whole exome sequencing reveals novel and rare variants in nonsyndromic hearing loss-related genes: A focus on compound heterozygosity.

Non-syndromic hearing loss (NSHL) is a genetically heterogeneous disorder affecting millions worldwide. Recent advances in genetic technologies have expanded our understanding of its molecular basis, but challenges remain in identifying and interpreting causative variants. This study aimed to investigate the genetic etiology of NSHL using comprehensive genetic screening, with a focus on identifying rare and potentially pathogenic variants.

Dy/Ho-labeled porous hydroxyapatite microparticles for treatment of inflammatory joint diseases - Exploring the advantages of in vivo generator.

Holmium-166 [T = 26.8 h, E (max) = 1.74 MeV (48.

Organotin(IV) compounds catalyzed cyanide-free synthesis of α-iminonitriles.

Two polydentate pro-ligands (H2L1 and H3L2) have been reacted with different organotin(IV) halides such as PhSnCl, (-Bu)SnCl, and (-Bu)SnCl to synthesize six organotin(IV) compounds, [RSn(L)] (R = Ph (1), -Bu (2), -Bu (3)) and [RSn(HL)] (R = Ph (4), -Bu (5), -Bu (6)), respectively. All organotin(IV) compounds were characterized by FT-IR spectroscopy, H, C{H}, and Sn{H} NMR spectroscopy, HR-MS spectrometry, and single-crystal X-ray diffraction analysis. The single-crystal X-ray diffraction analyses reveal that all compounds contain a penta-coordinated tin atom except 1.

Spin-Free Exact Two-Component Linear Response Coupled Cluster Theory for the Estimation of Frequency-Dependent Second-Order Properties.

We have presented the theory, implementation, and benchmark results for the one-electronic variant of spin-free exact two-component (SFX2C1e) linear response coupled cluster (LRCCSD) theory for static and dynamic polarizabilities of atoms and molecules in the spin-summed formulation. The resolution of identity (RI) approximation for two-electron integrals has been used to reduce the computational cost of the calculation and has been shown to have a negligible effect on accuracy. The calculated static and dynamic polarizability values agree very well with the more expensive X2C-LRCCSD and the experimental results.

Vitamin D3 potentiates antimicrobial and antibiofilm activities of streptomycin and thymoquinone against Pseudomonas aeruginosa.

Biofilm formed by Pseudomonas aeruginosa is a three dimensional microbial matrix that confers multidrug resistance properties along with the proficiency to evade the host immune system. The present study aims to determine the combinatorial effects of vitamin D3 (cholecalciferol) with two already reported antibiofilm agents: streptomycin and thymoquinone separately against P. aeruginosa biofilms.

A relativistic third-order algebraic diagrammatic construction theory for electron detachment, attachment, and excitation problems.

We present the theory and implementation of a relativistic third-order algebraic diagrammatic construction [ADC(3)] method based on a four-component (4c) Dirac-Coulomb Hamiltonian for the calculation of ionization potentials (IPs), electron affinities (EAs), and excitation energies (EEs). Benchmarking calculations for IP, EA, and EE were performed on both atomic and molecular systems to assess the accuracy of the newly developed four-component relativistic ADC(3) method. The results show good agreement with the available experimental data.

Analytic calculation of transition dipole moment using four-component relativistic equation-of-motion coupled-cluster expectation value approach.

We have developed an efficient scheme for the calculation of transition properties within the four-component relativistic equation-of-motion coupled cluster (EOM-CC) method using the expectation value approach. The calculation of transition properties within the relativistic EOM-CC framework requires the solution of both right and left eigenvectors. The accuracy of the approach has been investigated by calculating low-lying transitions of a Xe atom, a HI molecule, and spin forbidden 1S0 → 3P1 and spin allowed 1S0 → 1P1 transitions in a few closed shell cations.

Multi-dose formulation and clinical deployment of [Y]Y-labeled hydroxyapatite (HA) microparticles for radiation synovectomy in India- the inherent intricacies.

The present article describes intricate details involved in the formulation and quality control of 113 ready to use doses of [Y]Y-labeled hydroxyapatite (HA) microparticles for clinical use in radiation synovectomy using Y produced by (n,γ) route. Yttrium-90 was produced with a specific activity of 720 ± 95 MBq/mg of Y and radionuclidic purity of >99.9%.

Emerging role of electrochemistry in radiochemical separation of medically important radiometals: state of the art.

Electrochemical separation technology has brought a renaissance in the field of nuclear medicine towards obtaining clinical-grade radiometals for preparation of a wide variety of radiopharmaceuticals. This article is a comprehensive summary of the electrochemical processes developed for the separation of radiometals that could be used for diagnostic or therapeutic applications in nuclear medicine. For using electrochemistry as a tool for the separation of radiometals, intricate knowledge is essential to understand the basic parameters of electrochemical separation processes which include applied potential, selection of electrolyte, choice of the electrode, the temperature of the electrolyte, pH of the electrolyte and time of electrolysis.

pH-Responsive magnetic nanocarriers for chelator-free bimodal (MRI/SPECT-CT) image-guided chemo-hyperthermia therapy in human breast carcinoma.

Although chemotherapy with magnetic nanocarriers has witnessed significant advancement in the field of cancer treatment, multimodal diagnosis and combinatorial therapy using a single nanoplatform will have much better efficacy in achieving superior results. Herein, we constructed a smart theranostic system by combining pH-sensitive tartaric acid-stabilized FeO magnetic nanocarriers (TMNCs) with SPECT imaging and a chemotherapeutic agent for image-guided chemo-hyperthermia therapy. The carboxyl-enriched exteriors of TMNCs provided sites for the conjugation of a chemotherapeutic drug (doxorubicin hydrochloride, DOX) and radiolabeling (Ce).

[ 64 Cu]Copper chloride PET-CT: a comparative evaluation of fasting and non-fasting states in patients of prostate carcinoma.

Altered copper metabolism in cancer has been linked to increased intracellular copper uptake mediated by human copper transporter 1, with [ 64 Cu]Cu 2+ as a potential biomarker for cancer theranostics. [ 64 Cu]CuCl 2 PET-CT though explored in various malignancies, a lack of standardized protocol exists, particularly regarding fasting status before imaging. This analysis aimed to evaluate the requirement of fasting for [ 64 Cu]CuCl 2 PET-CT along with temporal changes in physiological organ uptake in delayed scans.

A reduced cost four-component relativistic unitary coupled cluster method for atoms and molecules.

We present a four-component relativistic unitary coupled cluster method for atoms and molecules. We have used commutator-based non-perturbative approximation using the "Bernoulli expansion" to derive an approximation to the relativistic unitary coupled cluster method. The performance of the full quadratic unitary coupled-cluster singles and doubles method (qUCCSD), as well as a perturbative approximation variant (UCC3), has been reported for both energies and properties.

Post-GWAS functional analyses of suggests its role in glaucomatous neurodegeneration.

Primary angle closure glaucoma (PACG) affects more than 20 million people worldwide, with an increased prevalence in south-east Asia. In a prior haplotype-based GWAS, we identified a novel genic region, significantly associated with PACG. In the current study, we have extended our perception of involvement in glaucomatous neurodegeneration in a zebrafish model, through investigating phenotypic consequences pertinent to retinal degeneration upon knockdown of cntnap5 by translation-blocking morpholinos.

Targeting Breast Cancer Using 177 Lu-Labeled Trastuzumab and Trastuzumab Fragment : First-in-Human Clinical Experience.

Purpose: A monoclonal antibody, trastuzumab, is used for immunotherapy for HER2-expressing breast cancers. Large-sized antibodies demonstrate hepatobiliary clearance and slower pharmacokinetics. A trastuzumab fragment (Fab; 45 kDa) has been generated for theranostic use.

ZnAlO:Er Upconversion Nanophosphor for SPECT Imaging and Luminescence Modulation via Defect Engineering.

This work reports an "all-in-one" theranostic upconversion luminescence (UCL) system having potential for both diagnostic and therapeutic applications. Despite considerable efforts in designing upconversion nanoparticles (UCNPs) for multimodal imaging and tumor therapy, there are few reports investigating dual modality SPECT/optical imaging for theranostics. Especially, research focusing on in vivo biodistribution studies of intrinsically radiolabeled UCNPs after intravenous injection is of utmost importance for the potential clinical translation of such formulations.

177 Lu-Microspheres Selective Intra-arterial Radionuclide Therapy : A Facile and Biocompatible Permanent Micro-Seed Implants for Unresectable Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is an aggressive malignancy with a poor prognosis. Surgical resection is limited. Selective intra-arterial radionuclide therapy (SIRT) emerged as a potential cure for intermediate HCC with portal vein thrombosis.

Synthesis, Quality Control, and Bench-to-Bed Translation of a New [Ga]Ga-Labeled NOTA-Conjugated Bisphosphonate for Imaging Skeletal Metastases by Positron Emission Tomography.

: Early detection of skeletal metastasis is of great interest to determine the prognosis of cancer. Positron emission tomography-computed tomography (PET-CT) imaging provides a better temporal and spectral resolution than single photon emission computed tomography-computed tomography (SPECT-CT) imaging, and hence is more suitable to detect small metastatic lesions. Although [F]NaF has been approved by U.