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This report describes a rare case of hilar cholangiocarcinoma with intratumoral calcification that mimicked hepatolithiasis. A 73-year-old man presented to a local hospital with a calcified lesion in the hepatic hilum. At first, hepatolithiasis was diagnosed, and he underwent endoscopic stone extraction via the trans-papillary route. This treatment strategy failed due to biliary stricture. He was referred to our hospital, and further examination suggested the existence of cholangiocarcinoma. He underwent left hepatectomy with caudate lobectomy and extrahepatic bile duct resection. Pathological examination revealed hilar cholangiocarcinoma with intratumoral calcification, while no stones were found. To the best of our knowledge, only one case of calcified hilar cholangiocarcinoma has been previously reported in the literature. Here, we report a rare case of calcified hilar cholangiocarcinoma and reveal its clinicopathologic features.
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http://dx.doi.org/10.3748/wjg.v21.i38.10926 | DOI Listing |
HPB (Oxford)
August 2025
Nottingham University Hospitals NHS Trust, Nottingham, UK. Electronic address:
Background: The role of liver transplantation as a treatment option for de novo resectable peri-hilar cholangiocarcinoma (pCCA) is controversial. This study investigated the outcomes following resection of early-stage pCCA in the UK.
Methods: Patients undergoing resection for pCCA between 2014 and 2022 across 22 UK centres were included.
Int J Surg
September 2025
Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou.
Background And Aims: Hilar cholangiocarcinoma (HC) is a challenging malignancy with limited treatment options. Radiofrequency ablation (RFA) has emerged as a potential palliative treatment, but its efficacy and safety remain controversial. This systematic review and meta-analysis aimed to evaluate the impact of RFA + stent (RFA + S) and stent only (S-only) on HC patients.
View Article and Find Full Text PDFJ Gastrointest Surg
September 2025
Digestive Health Institute, AdventHealth Tampa, Florida. Electronic address:
Anticancer Res
September 2025
Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand;
Background/aim: Perihilar cholangiocarcinoma (pCCA) is an aggressive bile duct cancer with a poor prognosis (10-40% 5-year survival after resection), that is mostly found in Thailand and has limited prognostic models. Copy neutral loss of heterozygosity (cnLOH) in various cancers affects their progression leading to poorer overall survival. This study aimed to explore cnLOH patterns in individual pCCA patients in order to develop a predictive model for prognostic biomarkers.
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August 2025
Surgical Oncology, Swedish Health Services, Seattle, WA, USA.
Hilar cholangiocarcinoma (HCCA) is a rare, aggressive cancer often diagnosed at an unresectable stage. Patients commonly require systemic therapy and biliary stenting to manage symptoms and maintain liver function. Histotripsy is a novel, non-invasive, mechanical ablation technique recently FDA-approved for liver tumors.
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