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This paper addresses an optimization problem in choosing optimum window length for feature extraction in automatic seizure detection. The processing window length plays an important role in reducing the false positive and false negative rates and decreasing required processing time for seizure detection. This study presents an approach for selecting the optimum window length toward the extraction of dynamical similarity index (DSI) feature. Then, the optimal window value in DSI extraction was used to detect seizure onset automatically. The algorithm was applied to electroencephalogram (EEG) signals from European Epilepsy Database. Although the main purpose of this study was not the seizure detection and mainly focuses on proposing an approach for finding an optimum window length for feature extraction towards the early seizure detection, the results showed that the proposed method achieves 83.99% of sensitivity in seizure detection. The low false positive rate per hour (FPR/h) was also significant due to continuous EEG analysis. The method showed fast computation speed which promises a potential for the real time applications. The proposed method for the window optimization in feature extraction of DSI can be implemented for other features to further improve the performance of seizure detection.
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http://dx.doi.org/10.1109/EMBC.2014.6944061 | DOI Listing |
Eur J Case Rep Intern Med
August 2025
Division of Internal Medicine, University Hospital of Basel, Basel, Switzerland.
Unlabelled: Encephalitis is a potentially life-threatening condition with infectious or autoimmune aetiologies. Autoimmune encephalitis includes paraneoplastic variants associated with specific onconeural antibodies such as anti-Hu, frequently linked to malignancies. Herpes simplex virus type 1 (HSV-1) is the leading infectious cause in adults.
View Article and Find Full Text PDFJ Neural Eng
September 2025
University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104-6243, UNITED STATES.
New implantable and wearable devices hold great promise to help patients manage their seizure disorders. One proposed application is measuring the rate of interictal epileptiform discharges as a biomarker of medication levels and seizure risk. This study aims to determine whether interictal epileptiform spike rates (spikes) are independently associated with anti-seizure medication (ASM) levels and evaluate whether spike rates are a reliable biomarker for ASM levels.
View Article and Find Full Text PDFJ Feline Med Surg
September 2025
Department for Small Animals, Veterinary Faculty, Leipzig University, Leipzig, Germany.
ObjectivesThe objective of this study was to evaluate the occurrence of voltage-gated potassium channel (VGKC) antibodies and the pattern of MRI changes in cats with complex partial seizures with orofacial involvement (CPSOFI), as well as to investigate whether there are factors influencing survival that could be used as prognostic markers in those cats.MethodsCats with CPSOFI were identified retrospectively. The following data were retrieved from the hospital database: signalment, age at first seizure and presentation, the presence of antibodies against VGKC (leucine-rich glioma inactivating factor 1 (LGI1), contactin-associated protein 2 (CASPR2)) and cerebrospinal fluid (CSF) analysis findings.
View Article and Find Full Text PDFEpilepsy Res
August 2025
University of Colorado School of Medicine, Aurora, CO, USA.
Objectives: Responsive neurostimulation (RNS) electrocorticographic (ECoG) data may have a role in objectively assessing the efficacy of add-on antiseizure medications (ASMs). This retrospective, multicenter, observational, 24-week study is the first to report the effects of cenobamate on RNS-detected events (RDE).
Methods: Patients included adults (≥18 years) with a history of recurrent focal seizures and implanted RNS who initiated adjunctive cenobamate ≥ 3 months after RNS implant between 4/1/20-12/15/23 and who received ≥ 2 weeks of cenobamate (≥50 mg/day).
Epilepsy Behav
September 2025
Neurology Division, Department of Pediatrics, Phramongkutklao Hospital, Bangkok, Thailand. Electronic address:
Background: Levetiracetam commonly causes neuropsychiatric adverse events (NPAEs) in pediatric patients, including irritability and aggression. This study evaluated pyridoxine supplementation for reducing levetiracetam-related NPAEs in children and adolescents with epilepsy.
Methods: We conducted a prospective, double-blind, randomized, placebo-controlled trial at Phramongkutklao Hospital, Thailand (January-June 2024).