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Purpose: To quantify the physiological responses, time-motion characteristics, and reproducibility of various speed-endurance-production (SEP) and speed-endurance-maintenance (SEM) drills.
Methods: Sixteen elite male youth soccer players completed 4 drills: SEP 1 v 1 small-sided game (SSG), SEP running drill, SEM 2 v 2 SSG, and SEM running drill. Heart-rate response, blood lactate concentration, subjective rating of perceived exertion (RPE), and time-motion characteristics were recorded for each drill.
Results: The SEP and SEM running drills elicited greater (P < .05) heart-rate responses, blood lactate concentrations, and RPE than the respective SSGs (ES 1.1-1.4 and 1.0-3.2). Players covered less (P < .01) total distance and high-intensity distance in the SEP and SEM SSGs than in the respective running drills (ES 6.0-22.1 and 3.0-18.4). Greater distances (P < .01) were covered in high to maximum acceleration/deceleration bands during the SEP and SEM SSGs than the respective running drills (ES 2.6-4.6 and 2.3-4.8). The SEP SSG and generic running protocols produced greater (P < .05) blood lactate concentrations than the respective SEM protocols (ES 1.2-1.7). Small to moderate test-retest variability was observed for heart-rate response (CV 0.9-1.9%), RPE (CV 2.9-5.7%), and blood lactate concentration (CV 9.9-14.4%); moderate to large test-retest variability was observed for high-intensity-running parameters (CV > 11.3%) and the majority of accelerations/deceleration distances (CV > 9.8%) for each drill.
Conclusions: The data demonstrate the potential to tax the anaerobic energy system to different extents using speed-endurance SSGs and that SSGs elicit greater acceleration/ deceleration load than generic running drills.
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http://dx.doi.org/10.1123/ijspp.2013-0390 | DOI Listing |
Ann Hematol
September 2025
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Approximately 30-40% of diffuse large B-cell lymphoma (DLBCL) patients will develop relapse/refractory disease, who may benefit from novel therapies, such as CAR-T cell therapy. Thus, accurate identification of individuals at high risk of early chemoimmunotherapy failure (ECF) is crucial. Methods.
View Article and Find Full Text PDFEur J Case Rep Intern Med
July 2025
Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
Background: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening hematologic emergency caused by ADAMTS13 deficiency, leading to microvascular thrombosis, haemolytic anaemia, thrombocytopenia, and end-organ damage. Neurological symptoms occur in up to 90% of cases and are frequently misdiagnosed as stroke. Prompt recognition and treatment reduce the mortality rate from over 90% to 10-20%.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Introduction: Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a neuropsychiatric disorder with additional psychiatric features caused by NMDA-R immunoglobulin G (IgG) antibodies in cerebrospinal fluid (CSF). This report presents the follow-up of a patient in whom we assumed mild NMDA-R encephalitis in the first psychotic episode.
Case Study: A patient with a prior episode of an acute polymorphic psychotic syndrome relapsed five and a half years later following a severe COVID-19 infection.
Vet World
July 2025
Faculty of Veterinary Medicine, Universitas Brawijaya, Malang, East Java 65151, Indonesia.
Background And Aim: is a significant pathogen in freshwater aquaculture, contributing to high morbidity and mortality in common carp (). Conventional reliance on antibiotics raises concerns about resistance and environmental impact. This study aimed to evaluate the effects of short-term fasting (1 or 2 days) on physiological, oxidative stress, and microbial responses in infected with .
View Article and Find Full Text PDFRev Bras Ortop (Sao Paulo)
June 2025
Department of Orthopedics and Traumatology, Faculty of Medicine, Udayana University, Prof. Ngoerah General Hospital, Bali, Indonesia.
Objective: The present study explores the association between these inflammatory markers and metastasis in osteosarcoma patients.
Methods: We conducted a retrospective analysis of osteosarcoma patients at our center between January 2022 and August 2024. We collected the clinical and laboratory data of the patients, including white blood cell differential count, C-reactive protein (CRP) levels, erythrocyte sedimentation rate (ESR), neutrophil-to-lymphocyte ratio (NLR), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) levels.