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The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational controlled multicentre international study aimed at defining clinically relevant subtypes of chronic obstructive pulmonary disease (COPD) and identifying novel biomarkers and genetic factors. So far, the ECLIPSE study has produced more than 50 original publications and 75 communications to international meetings, many of which have significantly influenced our understanding of COPD. However, because there is not one paper reporting the biomarker results of the ECLIPSE study that may serve as a reference for practising clinicians, researchers and healthcare providers from academia, industry and government agencies interested in COPD, we decided to write a review summarising the main biomarker findings in ECLIPSE.
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http://dx.doi.org/10.1136/thoraxjnl-2013-204778 | DOI Listing |
J Appl Clin Med Phys
September 2025
Department of Radiation Oncology, University of Utah, Salt Lake City, Utah, USA.
Purpose: The development of on-board cone-beam computed tomography (CBCT) has led to improved target localization and evaluation of patient anatomical change throughout the course of radiation therapy. HyperSight, a newly developed on-board CBCT platform by Varian, has been shown to improve image quality and HU fidelity relative to conventional CBCT. The purpose of this study is to benchmark the dose calculation accuracy of Varian's HyperSight cone-beam computed tomography (CBCT) on the Halcyon platform relative to fan-beam CT-based dose calculations and to perform end-to-end testing of HyperSight CBCT-only based treatment planning.
View Article and Find Full Text PDFAntipyretic analgesics are typical pharmaceutical and personal care products (PPCPs) that are widely used in our daily life because they relieve fever and pain, and have anti-inflammatory and anti-rheumatic properties. These drugs inhibit the synthesis and release of prostaglandins (PGs) in the neurons of the anterior hypothalamus and exert therapeutic effects as a consequence. However, these drugs are relatively commonly misused and abused, often owing to a lack of proper medication guidance.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Radiation Oncology, The Affiliated Huizhou Hospital, Guangzhou Medical University, Huizhou, China.
Background: Breast cancer is the foremost malignancy threatening female health. This study aimed to compare the dosimetric performance of Halcyon 3.0 and TrueBeam in Volumetric Modulated Arc Therapy (VMAT) planning for breast cancer.
View Article and Find Full Text PDFmedRxiv
August 2025
Channing Division of Network Medicine, Mass General Brigham, Boston, MA.
Objectives: To construct multi-trait polygenic scores (PRS) predicting chronic obstructive pulmonary disease (COPD) and exacerbations, validate their performance in diverse cohorts, and identify PRS-related proteins for potential therapeutic targeting.
Design: Prospective cohort studies.
Setting: Genetic Epidemiology of COPD (COPDGene; 2007-present), Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE; 2005-2008), Mass General Brigham Biobank (MGBB; 2010-present), All of Us (2016-present), and UK Biobank (UKB; 2006-present).
Angew Chem Int Ed Engl
September 2025
School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243000, China.
The photocatalytic efficiency of two-dimensional covalent organic frameworks (2D COFs) is governed by the spatial arrangement of donor-acceptor (D-A) moieties, which strongly influences exciton transport. However, precise control over D-A alignment, especially across intra- and interlayer dimensions, remains a key challenge for optimizing singlet oxygen (O) generation. Here, we present a linker geometry-directed approach to modulate D-A organization within perylene diimide (PDI)-based COFs.
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