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A copper-catalyzed one-pot process for the construction of benzo[4,5]imidazo[1,2-a]quinoxalines under air is described. Aryl chlorides, aryl bromides, and aryl iodides can be applied to the synthesis of these compounds.
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http://dx.doi.org/10.1021/ol4026292 | DOI Listing |
Org Biomol Chem
September 2025
Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune-410008, India.
A facile and efficient one-pot rongalite-mediated self-dimerization of 3-acylidene-2-oxindoles has been developed for the diastereoselective synthesis of highly functionalized dispirocyclopentanebisoxindoles. The reaction proceeds a domino sequence involving intermolecular Michael addition followed by intramolecular aldol cyclization under basic conditions. Rongalite, an inexpensive and readily available reagent (∼$0.
View Article and Find Full Text PDFOrg Lett
September 2025
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
We report Lewis acid-catalyzed direct conversion of carboxylic acids into primary amides and nitriles using bis(trimethylsilyl)amine as an ammonia surrogate. With 1.1 equiv of bis(trimethylsilyl)amine, ytterbium(III) and hafnium(IV) triflates efficiently catalyzed the reaction, affording various primary amides in high yields with a broad substrate scope.
View Article and Find Full Text PDFJ Fluoresc
September 2025
School of Intelligent Manufacturing, Huzhou College, Huzhou, 313000, P.R. China.
The antibiotic contamination in aquatic environments, particularly in aquaculture systems, poses substantial risks to ecological balance and human health. To address this issue, we engineered a novel ratiometric fluorescent probe utilizing dual-emission carbon dots (D-CDs) synthesized from sustainable biomass carrot and nitrogen-rich precursors (melamine and o-phenylenediamine) through an efficient one-pot hydrothermal approach. The D-CDs exhibited dual emission peaks at 425nm and 540 nm under 370nm excitation.
View Article and Find Full Text PDFAnal Bioanal Chem
September 2025
Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Military Medical Sciences Academy, Tianjin, 300050, China.
Rapid, low-cost, and visual nucleic acid detection methods are highly attractive for curbing colistin resistance spread through the food chain. CRISPR/Cas12a combined with recombinase-aided amplification (RAA) offers a one-pot, aerosol-free approach for visual detection. However, traditional one-pot systems often run Cas12a trans-cleavage in a buffer suitable for RAA, thus limiting Cas12a cleavage efficiency.
View Article and Find Full Text PDFAnal Chem
September 2025
RUSA-Center for Advanced Sensor Technology, Department of Physics, Dr. Babasaheb Ambedkar Marathwada University, Chhatrapati Sambhajinagar (Aurangabad), Maharashtra 431 004, India.
In this study, a one-pot hydrothermal synthesis method was used to synthesize a novel gold-yttrium trimesic acid metal-organic framework (Au-Y-TMA MOF), demonstrating significant improvements over conventional single-metal MOFs, that is, yttrium trimesic acid (Y-TMA), in both supercapacitor applications and electrochemical antibiotic detection. The X-ray diffraction patterns of Au-Y-TMA confirmed the presence and impact of Au in the Y-TMA matrix, while field emission scanning electron microscopy (FE-SEM) images revealed a heterogeneous combination of gold nanoparticles (AuNPs) and Y-TMA, suggesting a nonuniform distribution and possible interaction. The developed half-cell supercapacitor exhibited a remarkable capacitance value of 1836 F/g at a current density of 5 A/g by galvanostatic charging-discharging (GCD) measurement.
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