Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
An efficient cyclopropanation of olefins with Zn(CH2I)2, a catalytic amount of CCl3CO2H, and 1,2-dimethoxyethane at room temperature is described. A wide variety of olefins, including acid-sensitive substrates, can be cyclopropanated in 71-99% yield.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c3ob40751a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
"Cut-and-Sew" Reactions of β-Lactams via C-C Bond Activation.
J Am Chem Soc
September 2025
Department of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.
Transition metal-catalyzed "cut-and-sew" reactions offer an efficient approach to construct bridged and fused scaffolds; however, the substrates have been primarily restricted to cyclic ketones and activated cyclopropanes. Here we report the first cut-and-sew transformation between β-lactams and alkenes/alkynes via C-C bond activation. Diverse bridged and fused nitrogen-heterocycles are prepared using this method with good functional group tolerance.
View Article and Find Full Text PDFDirect Carboboration of Aryl Alkenes with Stable Organoborons Through Ziegler-Type Addition.
Adv Sci (Weinh)
August 2025
State Key Laboratory of Coordination Chemistry, Key Laboratory of Mesoscopic Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
Carbometallation reaction represents a classic strategy for the bifunctionalization of unsaturated hydrocarbons, yet conventional implementations predominantly rely on either highly reactive organometallic reagents or transition metal catalysts. Notably, the direct employment of metalloid organoboron reagents for such addition processes remains elusive except when specific substrate combinations are employed. Herein, a base-catalyzed carboboration reaction of aryl alkenes with bench-stable benzylic boronates is reported.
View Article and Find Full Text PDFPLK4 as a Key Regulator of Neuroblastoma Differentiation and a Promising Therapeutic Target.
Int J Biol Sci
August 2025
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin, China.
Neuroblastoma (NB) differentiation status critically influences prognosis and treatment response. Although differentiation therapy has shown clinical benefit, its efficacy remains limited. The molecular mechanisms driving NB differentiation are not fully understood.
View Article and Find Full Text PDFEngineered hemoproteins containing non-canonical cofactors toward artificial metalloenzymes.
J Inorg Biochem
December 2025
Department of Applied Chemistry, Graduate School of Engineering, The University of Osaka, Suita, Osaka 565-0871, Japan; Innovative Catalysis Science Division, Institute for Open and Transdisciplinary Research Initiatives (ICS-OTRI), The University of Osaka, Suita, Osaka 565-0871, Japan. Electronic a
Hemoproteins have emerged as versatile scaffolds for the construction of artificial metalloenzymes. Through directed evolution via random and/or site-saturation mutagenesis, these proteins can be repurposed to catalyze abiological transformations. Their catalytic scope can be further expanded by introducing non-canonical molecular components.
View Article and Find Full Text PDFA Data Science-Guided Approach for the Development of Nickel-Catalyzed Homo-Diels-Alder Reactions.
J Am Chem Soc
August 2025
The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
The Ni-catalyzed homo-Diels-Alder (hDA) reaction represents a convergent but under-investigated approach to preparing bridged bicyclic ring systems. Using the monophosphine descriptor library, Ni-catalyzed hDA reactions of acyclic and cyclic electron deficient olefins were investigated, and key ligand effects required for reactivity were identified using classification models. This analysis guided the discovery of the monophosphine ()-AntPhos as a chiral ligand for the enantioselective hDA of acyclic dienophiles.
View Article and Find Full Text PDF