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The dietary intakes of sodium saccharin, aspartame and stevioside were estimated on the basis of food consumption data of the Korean consumer and the concentration of sweeteners in processed foods. Results were compared with the acceptable daily intake (ADI) of sweeteners. Among the 28 food categories for which the application of sodium saccharin, aspartame and stevioside is permitted in Korea, they were detected in 5, 12 and 13 categories, respectively. The estimated daily intake (EDI) of sodium saccharin and aspartame were high in infants and children, whereas the EDI of stevioside was high in adolescents and adults. The most highly consumed sweetener was aspartame, and the highest EDI/ADI ratio was found for sodium saccharin. The main food categories contributing to sweetener consumption were beverages, including alcoholic beverages. For most Korean consumers, the EDIs were no greater than 20% of their corresponding ADI; however, the EDI of sodium saccharin for conservative consumers aged 1-2 years reached 60% of their ADI.
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http://dx.doi.org/10.1080/19440049.2013.797114 | DOI Listing |
Neurology
October 2025
Division of Geriatrics, Faculdade de Medicina, Universidade de São Paulo, Brazil.
Background And Objectives: Consumption of low- and no-calorie sweeteners (LNCSs) has been associated with adverse health outcomes. However, little is known about the association between consumption of LNCSs and cognition. The aim of this study was to investigate the association between consumption of LNCSs and cognitive decline.
View Article and Find Full Text PDFFront Syst Neurosci
August 2025
Sagol Department of Neuroscience, The Integrated Brain and Behavior Center, University of Haifa, Haifa, Israel.
Measuring precise emotional tagging for taste information, with or without the use of words, is challenging. While affective taste valence and salience are core components of emotional experiences, traditional behavioral assays for taste preference, which often rely on cumulative consumption, lack the resolution to distinguish between different affective states, such as innate versus learned aversion, which are known to be mediated by distinct neural circuits. To overcome this limitation, we developed an open-source system for high-resolution microstructural analysis of licking behavior in freely moving mice.
View Article and Find Full Text PDFPharmacol Biochem Behav
August 2025
Department of Psychology, Fo Guang University, Yilan County 26247, Taiwan. Electronic address:
The impact of stress on the behaviors and neural substrates underlying opioid use disorder (OUD) remains unclear. To investigate this, we employed a footshock treatment before the pre- and post-conditioning procedures for conditioned taste aversion (CTA) and conditioned place preference (CPP) with morphine injections. In the experiment, all rats were subjected to 10-second footshock (3 mA) or no footshock treatments.
View Article and Find Full Text PDFBehav Brain Res
August 2025
Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Japan.
The basolateral amygdala (BLA) plays a critical role in aversive learning and decision‑making, yet its specific contribution to the expression of conditioned taste aversion (CTA) remains incompletely understood. Here, we examined how transient chemogenetic inhibition of the BLA influences licking microstructure and approach-avoidance behavior toward a conditioned saccharin solution. Male C57BL/6 mice received bilateral BLA injections of AAV8‑hSyn‑hM4Di‑mCherry (experimental) or AAV8‑hSyn‑mCherry (control).
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Non-nutritive sweetener (NNS) administration has been proven to be likely related to cardiovascular disease (CVD) risk. However, the effect of saccharin (SA), a major daily consumed NNS, on atherosclerosis (AS) progression remains insufficiently elucidated. In this study, free drinking water plus 0.
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