Potassium iodide catalyzed simultaneous C3-formylation and N-aminomethylation of indoles with 4-substituted-N,N-dimethylanilines.

Org Biomol Chem

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, 94 Weijin Road, Tianjin 300071, China.

Published: December 2012


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Article Abstract

A one-pot dual functionalization of indoles has been developed. The simultaneous C3-formylation and N-aminomethylation of indoles can be achieved using readily available potassium iodide as a catalyst and tert-butyl peroxybenzoate as a co-oxidant.

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http://dx.doi.org/10.1039/c2ob26636aDOI Listing

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