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REM sleep behavior disorder (RBD) is one of the most important factors predicting Parkinson's disease. Symptoms constitute vivid dreams typically characterized by ominous contents and associated muscular activity. Specific signs include the preservation of muscle tone during REM sleep as detected in polysomnography, and behavior associated with dreaming as demonstrated by video monitoring. Injury risk is increased during the attacks. Melatonin or clonazepam can be used as therapy. The disorder belongs to the entity of synucleinopathies.
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Alzheimers Dement
September 2025
School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Camperdown, Sydney, New South Wales, Australia.
Introduction: Risperidone is approved for behaviors and psychological symptoms of dementia (BPSD), despite modest efficacy and known risks. Identifying responsive symptoms, treatment modifiers, and predictors is crucial for personalized treatment.
Method: A one-stage individual participant data meta-analysis of six randomized controlled trials (risperidone: n = 1009; placebo: N = 712) was conducted.
J Epidemiol
September 2025
Faculty of Sport Sciences, Waseda University.
Background: Brief measures of 24-hour movement behaviors are needed to easily evaluate their durations. The present study investigated the criterion validity and test-retest reliability of a brief self-report instrument to assess 24-hour movement behaviors.
Methods: A paper-based self-administered questionnaire was used to assess sleep, sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with four items in 35 healthy adults.
J Affect Disord
September 2025
Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea; Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; D
Background: Major depressive disorder (MDD), anxiety disorders, and self-harm are substantial contributors to the global disease burden, exacerbated by the COVID-19 pandemic.
Methods: We used Global Burden of Diseases Study (GBD) 2021 to estimate global, regional, and national prevalence, mortality, and disability-adjusted life years (DALYs) for MDD, anxiety disorders, and self-harm from 1990 to 2021. Annual percentage changes were calculated for pre-pandemic (1990-2019) and pandemic (2019-2021) periods.
Sleep Med
August 2025
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Zuid-Holland, the Netherlands; Trimbos Institute - Netherlands Institute for Mental Health and Addiction, Utrecht, the Netherlands. Electronic address:
Objectives: Sleep is known to change around pregnancy. Yet current studies often do not take into account the multidimensionality of sleep and its changes from preconception to postpartum. Therefore, this study aims to explore maternal multivariate sleep trajectory from preconception to 6 months postpartum and related determinants.
View Article and Find Full Text PDFMil Med
September 2025
School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.
Introduction: Submarine environments pose unique challenges to maintaining physical activity and exercise routines due to confined spaces, demanding schedules, and limited resources. This study investigated submariners' physical activity patterns, sleep quality, and perceived exercise barriers in both land- and sea-based settings, with the goal of informing targeted health interventions.
Materials And Methods: Ethics approval was granted by the Defence Science and Technology Group and Edith Cowan University review panels.