Impact of REM Sleep Behavior and Sleep Talking on Mortality in Parkinson's Disease.

Background REM sleep behavior disorder (RBD) is a prodromal marker for Parkinson's disease (PD) and other alpha-synucleinopathies. Sleep talking (ST) is an isolated symptom and is frequent in PD and RBD. Here, we investigate the associations of ST and RBD with the mortality of PD patients.

Parkinson's disease and insomnia.

There is a broad spectrum of sleep disturbances observed in Parkinson's disease (PD). The prevalence of symptoms of insomnia and chronic inability to sleep and their association with other sleep disorders were studied. Altogether 1447 randomly selected Parkinson patients, aged 43-89 years, participated in a questionnaire study.

Parkinson's disease and restless legs syndrome.

Aims: Various sleep-related complications are common in Parkinson's disease (PD). The prevalence of restless legs syndrome (RLS) and its association with other symptoms were studied.

Methods: Altogether, 1,447 Parkinson patients, aged 43-89, participated in a questionnaire study.

Parkinson's disease and narcolepsy-like symptoms.

Objective: Various sleep-related problems, for example, insomnia and symptoms of rapid eye movement behavior disorder (RBD), are common in patients with Parkinson's disease (PD). We studied the prevalence of symptoms of narcolepsy (NARC), hallucinations, and RBD and their association with other symptoms.

Methods: Altogether, 1447 randomly selected patients with PD, aged 43-89 years, participated in a questionnaire study.

Parasomnias and isolated sleep symptoms in Parkinson's disease: a questionnaire study on 661 patients.

Background: Sleep disorders are among the most common non-motor symptoms in Parkinson's disease.

Method: The prevalence of parasomnias and their association with other symptoms were studied in a questionnaire study among 1447 randomly selected Parkinson patients, aged 43 to 89 years. The response rate was 59.

[REM sleep behavior disorder (RBD)].

REM sleep behavior disorder (RBD) is one of the most important factors predicting Parkinson's disease. Symptoms constitute vivid dreams typically characterized by ominous contents and associated muscular activity. Specific signs include the preservation of muscle tone during REM sleep as detected in polysomnography, and behavior associated with dreaming as demonstrated by video monitoring.

Altered generation of spontaneous oscillations in Alzheimer's disease.

Slowing of spontaneous alpha oscillations and an anterior shift of a source of alpha activity (8-13 Hz) have been consistently reported in the EEG studies of Alzheimer's disease (AD). It is unknown whether these changes are associated with a gradual shift in location and frequency of existing sources or rather with the involvement of a new set of oscillators. We addressed this question by applying source modeling (minimum current estimates, MCE) to spontaneous alpha activity recorded with a 306-channel MEG system from eleven non-medicated AD patients with mild to moderate cognitive impairment and twelve age-matched controls during the eyes-closed session.