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The increased variations of temporal gait events when pathology is present are good candidate features for objective diagnostic tests. We hypothesised that the gait events hoof-on/off and stance can be detected accurately and precisely using features from trunk and distal limb-mounted Inertial Measurement Units (IMUs). Four IMUs were mounted on the distal limb and five IMUs were attached to the skin over the dorsal spinous processes at the withers, fourth lumbar vertebrae and sacrum as well as left and right tuber coxae. IMU data were synchronised to a force plate array and a motion capture system. Accuracy (bias) and precision (SD of bias) was calculated to compare force plate and IMU timings for gait events. Data were collected from seven horses. One hundred and twenty three (123) front limb steps were analysed; hoof-on was detected with a bias (SD) of -7 (23) ms, hoof-off with 0.7 (37) ms and front limb stance with -0.02 (37) ms. A total of 119 hind limb steps were analysed; hoof-on was found with a bias (SD) of -4 (25) ms, hoof-off with 6 (21) ms and hind limb stance with 0.2 (28) ms. IMUs mounted on the distal limbs and sacrum can detect gait events accurately and precisely.
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http://dx.doi.org/10.3390/s120608145 | DOI Listing |
Cureus
August 2025
Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, USA.
Freezing of gait (FoG) is a disabling symptom of Parkinson's disease (PD) characterized by involuntary cessation/reduction. While deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) effectively treats common PD symptoms such as tremor, its impact on FoG is less clear. Rarely, STN-DBS itself can induce FoG.
View Article and Find Full Text PDFJ Am Geriatr Soc
September 2025
Frailty Research Center, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
Background: Prehabilitation may help older adults recover after surgery, yet adherence has been variable. We assessed the feasibility of a multi-component prehabilitation program.
Methods: This single-arm trial was conducted at an academic medical center to test the feasibility of an individualized prehabilitation program before major surgery.
Mov Disord
September 2025
Department of Functional Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Phase-amplitude coupling (PAC) in the beta-gamma range has emerged as a promising electrophysiological biomarker of Parkinson's disease (PD).
Objective: This study aims to investigate how levodopa and locomotion modulate cortical (central electroencephalogram [cEEG]) and corticomuscular (cEEG-gEMG [gastrocnemius electromyography]) beta-gamma PAC in patients with PD.
Methods: Thirty patients with PD underwent simultaneous cEEG and gEMG recordings during sitting, standing, and free walking in both off and on dopaminergic states.
BMJ Open
September 2025
Salisbury NHS Foundation Trust, Salisbury, UK.
Introduction: Difficulty with walking can lead to reduced quality of life for people with Parkinson's disease (pwPD); improving walking is considered a treatment priority. Drug therapies can control PD symptoms; however, pwPD often still experience mobility problems.Functional electrical stimulation (FES) induces movement in weak muscles via external electrical stimulation.
View Article and Find Full Text PDFJ Am Vet Med Assoc
September 2025
4CENTAURO Research Group, School of Veterinary Medicine, Faculty of Agrarian Sciences, Universidad de Antioquia, Medellín, Colombia.
Background: Canine osteoarthritis (OA) is a progressive degenerative joint disease causing pain and mobility impairment. While the disease is incurable, multimodal management including regenerative therapies like platelet-rich plasma (PRP) can improve outcomes. However, protocol standardization remains a challenge.
View Article and Find Full Text PDF