Publications by authors named "Preston N Wolfe"
Background: Canine osteoarthritis (OA) is a progressive degenerative joint disease causing pain and mobility impairment. While the disease is incurable, multimodal management including regenerative therapies like platelet-rich plasma (PRP) can improve outcomes. However, protocol standardization remains a challenge.
View Article and Find Full Text PDFObjective: Determine measurable differences for mechanistic urine and serum biomarkers in patients with developmental dysplasia of the hip (DDH) prior to, and following, secondary hip osteoarthritis (OA) when compared to controls.
Design: Urine and serum were collected from individuals with developmental dysplasia of the hip (n = 39), prior to (Pre-OA DDH, n = 32) and following diagnosis of secondary hip OA (Post-OA DDH, n = 7), age-matched Pre-OA controls (n = 35), and age-matched Post-OA controls (n = 12). Samples were analyzed for protein biomarkers with potential for differentiation of hip status through a Mann-Whitney test with a Benjamini-Hochberg correction.
Article Synopsis
- - The study aimed to evaluate serum and urine biomarker panels to distinguish between healthy hip individuals and those with developmental dysplasia of the hip (DDH) to help predict secondary hip osteoarthritis (OA) in young adults.
- - Researchers collected and analyzed samples from individuals with DDH and healthy controls, finding that specific biomarker panels could effectively differentiate between the two groups, with the best-performing panel showing a high Area Under Curve (AUC) score of 0.959.
- - The findings suggest that these biomarker panels could be clinically useful for early diagnosis and monitoring of DDH, providing a cost-effective screening method for at-risk populations.
Purpose: To provide an initial characterization of relevant bacterial DNA profiles for patients undergoing closed-fracture fixation or total joint arthroplasties.
Patients And Methods: Swabs were collected and analyzed using Polymerase Chain Reaction from adult patients undergoing closed-fracture fixation or total shoulder, knee, or hip arthroplasties.
Results: Bacterial DNA profiles varied across the different orthopaedic patient populations, and produced uncharacteristic profile shifts with direct relevance to each clinical infection.