Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This study is focused on the uptake of PLGA particles with different coatings and its influences on the functions and toxicity of human endothelial cells. The PLGA particles coated with polyethyleneimine (PEI) or bovine serum albumin (BSA) were prepared via a one-step emulsion method, which had a similar diameter of ∼420 nm in water and ∼170 nm in a dry state but oppositely charged surfaces. Both types of the particles were readily internalized into cells within a short time regardless of their surface chemistry. Uptake of the positively charged particles caused apparently a decrease in cell viability, but did not significantly influence mitochondrial membrane potential and activity of caspase-3. The cell adhesion and migration were significantly affected, especially after uptake of the PLGA-PEI particles. The secretion levels of von Willebrand factor (vWF) and 6-k-PGF(1α) were not significantly influenced regardless of the surface coating.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/bm3010484 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
"Engineering Rifampicin-Encapsulated Inhalable Microparticles for Precision Tuberculosis Therapy: In Vivo Distribution and Therapeutic Evaluation".
J Drug Target
September 2025
Department of Pharmaceutics, ShriRam College of Pharmacy, Banmore, Morena-476444, Madhya Pradesh, India.
Tuberculosis (TB) continues to cause significant global mortality, highlighting the need for improved drug delivery systems. The objective of this paper focuses in describing the formulation, optimization and in vivo assessment of rifampicin encapsulated PLGA microparticles for site-specific inhalation therapy. Microparticles for inhalation were produced by spray drying, and the DoE methodology was applied to reach the most suitable aerodynamic properties (mass median aerodynamics diameter (MMAD) 2.
View Article and Find Full Text PDFDissolution Enhancement of Lycopene Compacts by Liquisolid Technique.
Turk J Pharm Sci
September 2025
Gate Institute of Pharmaceutical Sciences, Telangana, India.
Objectives: Bortezomib (BTZ) functions as an androgen receptor signalling inhibitor, is used for the treatment of prostate cancer, and has been sanctioned by the United States Food and Drug Administration. The medicinal applications of BTZ are impeded by low solubility, first-pass metabolism, and restricted bioavailability. This study aimed to develop and enhance polylactic acid-co-glycolic acid (PLGA) nanobubbles (NBs) as a sustained-release mechanism for BTZ, thereby augmenting stability and bioavailability.
View Article and Find Full Text PDFCholesterol-Functionalized Porous PLA Microparticles for Enhanced Drug Delivery.
ACS Appl Bio Mater
September 2025
Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies (IMEM-BRT) Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/Eduard Maristany 10-14, Building I, second floor, Barcelona 08019, Spain.
A drug delivery platform based on highly porous poly(lactic acid) (PLA) microparticles functionalized with amphiphilic poly(ethylene glycol)-cholesterol (PEG-Chol) has been developed and successfully validated . This hybrid system addresses key limitations of conventional PLA and poly(lactide--glycolide) (PLGA) nanoparticles, providing better encapsulation and sustained drug release. The incorporation of PEG-Chol provides both enhanced aqueous dispersibility for prolonged circulation and membrane-anchoring capabilities, thereby promoting cellular interaction and endocytosis.
View Article and Find Full Text PDFThe Effects of PLGA Nanoparticles Containing Different Growth Factors on Neural Stem Cell Differentiation and Their Transition Efficiency After Targeting With TRF.
CNS Neurosci Ther
September 2025
Center for Stem Cell & Gene Therapies Research & Practice, Kocaeli University, Kocaeli, Turkey.
Aims: Nanoparticle-mediated drug delivery systems are being investigated for the controlled release of drugs to treat neurodegenerative diseases (ND). We aimed to investigate the effects of poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) containing different growth factors (GFs) on rat brain-derived neural stem cells (NSCs) in vitro differentiation, providing insights that may contribute to future approaches for treating Parkinson's disease.
Methods: Three different PLGA-NPs loaded with Brain-Derived Neurotrophic Factor (BDNF), Glial-Derived Neurotrophic Factor (GDNF), and Transforming Growth Factor beta 3 (TGF-β3) were developed and characterized in terms of size, zeta potential, encapsulation efficiency, and release profile.
Near-infrared laser-activated PLGA-PDA core-shell nanohybrids for synergistic photothermal antibacterial therapy and sustained ion release in orthodontic white spot lesions prevention.
J Dent
August 2025
Department of Orthodontics, Shanxi Provincial People's Hospital, The Fifth Clinical Medical College of Shanxi Medical University, Shanxi Medical University School and Hospital of Stomatology,Taiyuan 030001,China. Electronic address:
Objective: To develop near-infrared (NIR) laser-activated PLGA-PDA core-shell nanohybrids encapsulating Ag/CuO nanoparticles for simultaneous photothermal antibacterial therapy and sustained Ag/Cu release, and to evaluate their bactericidal efficacy against Streptococcus mutans and preventive potential in orthodontic white spot lesions.
Methods: Ag/CuO nanoparticles were encapsulated in PLGA/PDA nanospheres via a double-emulsion and self-polymerization approach. The resulting core-shell particles were fully characterized for composition, size distribution, zeta potential, morphology, photothermal performance, release kinetics, and cytocompatibility.