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We show that weak measurement can be used to "amplify" optical nonlinearities at the single-photon level, such that the effect of one properly postselected photon on a classical beam may be as large as that of many unpostselected photons. We find that "weak-value amplification" offers a marked improvement in the signal-to-noise ratio in the presence of technical noise with long correlation times. Unlike previous weak-measurement experiments, our proposed scheme has no classical equivalent.
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http://dx.doi.org/10.1103/PhysRevLett.107.133603 | DOI Listing |
Anal Chim Acta
November 2025
Institute of Materials Science, Vietnam Academy of Science and Technology, Hanoi, 10000, Viet Nam. Electronic address:
Background: Recent advancements in cancer therapeutics have catalyzed the development of noninvasive treatment modalities, including the utilization of fluorescent chemotherapeutic agents. These agents offer dual functionality, enabling targeted drug delivery, real-time tumor imaging, and personalized therapy monitoring. Such capabilities are instrumental in the progression toward more precise and effective cancer interventions.
View Article and Find Full Text PDFFocusing on the characteristics of large variation ranges in target signals and background noise in near-infrared Light Detection and Ranging (LiDAR) applications, this paper proposes a method of Linear/Geiger dual-mode detection based on InGaAs Avalanche Photodiodes (APDs) to meet the requirements of higher dynamic range response. Two structures combining an active quenching circuit and a transimpedance amplifier circuit were designed, and the dual-mode detection performance of the two designs was compared. Furthermore, the detector can achieve linear/Geiger dual-mode switching through rapid bias control based on Field-Programmable Gate Array (FPGA) and high-speed operational amplifiers.
View Article and Find Full Text PDFOpt Express
April 2025
We demonstrated a 972 nm single-frequency distributed Bragg reflector (DBR) Yb-doped fiber laser core-pumped by a watt-level 915 nm Nd-doped fiber laser. A 9 mm long home-fabricated highly Yb-doped silica fiber was used to build the DBR cavity. The direct output power of the 972 nm single frequency fiber laser (SFFL) could reach 42.
View Article and Find Full Text PDFInt J Pharm
October 2025
Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile.
The urgent necessity for early disease diagnosis and detection continues to drive innovation in imaging techniques and contrast agents. Nanoparticle-based bioimaging offers significant potential to enhance therapeutics, treatment management, and cancer diagnostics. In both clinical practice and biomedical research, nanoparticles (NPs) can serve as labeled carriers or biomarkers for tracking immunotherapy responses, contrast-enhancing agents for improved imaging, or signal amplifiers to increase specificity and sensitivity in the visualization of cellular and molecular mechanisms in vivo.
View Article and Find Full Text PDFBMJ Neurol Open
July 2025
University of Central Lancashire, Preston, UK.
Background: Functional neurological disorder (FND) frequently co-exists with chronic pain (CP), notably nociceptive and nociplastic (primary) pain disorders. The considerable overlap implies shared underlying mechanisms because of their similar clinical and epidemiological profiles. Although standard neuroimaging and electrophysiological tests typically show normal results in both FND and primary pain disorders, recent advancements in neuroimaging techniques have begun identifying neural biomarkers common to both conditions, though these findings remain preliminary and require further exploration.
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