Aspirin-Free Prasugrel Monotherapy After Percutaneous Coronary Intervention in Patients With Non-ST Elevation Acute Coronary Syndrome.

Background: In the presence of a potent P2Yinhibitor such as prasugrel, the additional clinical antithrombotic benefit of aspirin is unclear. The feasibility of prasugrel monotherapy without aspirin after percutaneous coronary intervention (PCI) has been demonstrated in chronic coronary syndrome, but is yet to be assessed in patients with non-ST elevation acute coronary syndrome (NSTE-ACS) and low anatomical complexity.

Methods And Results: ASET-Japan is a single-arm study investigating the safety of prasugrel 12-month monotherapy with a locally approved dose (loading 20 mg; maintenance 3.

Women's Experiences of Care and Support Following Postpartum Psychosis: A Meta-Ethnography.

Background: Postpartum psychosis is a psychiatric emergency that occurs following childbirth. Women are often cared for in general psychiatric units or in psychiatric Mother and Baby units. Postpartum psychosis is associated with a significant risk of relapse.

Development of a reusable and disposable sensor for the rapid determination of the human chorionic gonadotropin (hCG) biomarker.

Herein, we developed a previously undescribed electrochemical nanoMIP-based sensor for the sensitive, reusable and accurate determination of human chorionic gonadotropin (hCG). Using a proprietary rapid and scalable method, hCG-selective polyacrylamide nanoMIP particles were produced within 2 h in high yields of 11 mg per 1 mL reaction batch with hCG-modified magnetic nanoparticles (MNPs@CHO@hCG). The MNPs were reusable for 5 sequential cycles of nanoMIP production.

Prevalence and risk factors of burnout symptoms among nurses during the COVID-19 pandemic: an updated systematic review and meta-analysis.

Background: COVID-19 has been a substantial challenge for nurses globally, as they have gone through prolonged crisis times where they were continually under immense psychological pressure. Working in these conditions for months and years has resulted in an increase in the prevalence of job burnout among nurses. This systematic review was conducted to provide solid evidence on the prevalence of burnout and its related factors among nursing staff in different parts of the world after the occurrence of the COVID-19 pandemic.

Paid Organ Donation: Case Report and Review of the Literature on Health Implications for Kidney Donors and Recipients.

The shortage of organs for use in transplantation has contributed to the development of an international commercial market for organ transplantation. Unfortunately, transplant tourism (TT) is associated with risks for surgical complications, poor graft outcome, increased mortality, and infectious complications. TT increases the risk of several viral (HIV and hepatitis B and C viruses), bacterial ( sp.

Survival Prediction in Allogeneic Haematopoietic Stem Cell Transplant Recipients Using Pre- and Post-Transplant Factors and Computational Intelligence.

Advancements in artificial intelligence (AI) predictive models have emerged as valuable tools for predicting survival outcomes in allogeneic haematopoietic stem cell transplantation (allo-HSCT). These models primarily focus on pre-transplant factors, while algorithms incorporating changes in patient's status post-allo-HSCT are lacking. The aim of this study was to develop a predictive soft computing model assessing survival outcomes in allo-HSCT recipients.

A randomised controlled clinical and cost effectiveness trial of an online integrated bipolar parenting intervention (IBPI) compared to treatment as usual in improving child emotional and behavioural outcomes: a study protocol.

Background: Bipolar disorder (BD) is a severe mental health problem linked to substantial personal and social costs. Many individuals living with bipolar disorder are parents. Due to the nature of the condition, parents with BD often experience challenges in delivering consistent parenting.

Primary author contact for systematic reviews of randomized controlled trials: A systematic review.

Background: Systematic reviews (SRs) synthesize and evaluate data, mainly from randomized trials, which then guides the development of clinical recommendations in evidence-based medicine. However, the data and methodological information in the included papers can often be lacking or unclear, and reviewers usually need to contact the authors of included studies for clarifications. Contacting authors is recommended, but it is unclear how often SR teams do it, or what the level of response is.

Diagnostic performance of exercise stress testing findings and coronary microvascular dysfunction in patients with angina with non-obstructive coronary artery disease.

Background: Coronary microvascular dysfunction (CMD) is common among patients with angina with non-obstructive coronary artery disease (ANOCA) and leads to poorer clinical outcomes. Exercise stress testing (EST) was shown to have a high specificity for detecting CMD. However, the relationship between diagnosing CMD using different invasive physiological parameters and thresholds and the association between EST findings and the endotype of CMD remains unknown.

Needs and experiences of families after a sudden unexplained death in childhood: a qualitative study.

Background: Sudden unexplained death in childhood (SUDC) is a rare and devastating experience for families. In the UK, multi-agency investigation by police, health and social care of sudden, unexpected child deaths is a statutory requirement aiming to identify full causes for deaths. Families should be allocated bereavement keyworkers for support throughout the investigative process which can take several months.

Comprehensive geriatric assessment for older adults in the community.

With more than 11 million community-dwelling older adults in England and Wales, and one in four having two or more long-term conditions, the need to help older people to remain healthy and well is a priority. A comprehensive geriatric assessment is identified as a gold standard for improving outcomes for older adults in a hospital setting and is recommended for older adult inpatients. However, knowledge gaps remain on comprehensive geriatric assessment conducted in a community setting.

Evaluating the Implications of a Coronary Artery Calcium Score of Zero (CAC = 0) in Modern Risk Prediction: Is Zero Truly Zero?

Coronary artery calcium (CAC) scoring is a well-validated screening tool used to calculate the amount of calcified plaque deposited in coronary arteries from a computed tomography (CT) scan. It stratifies patients by risk to predict their future probability of cardiovascular disease and helps establish the ideal preventive therapies. Considering these factors, the purpose of this narrative review is to evaluate the latest research on the effectiveness of CAC scoring, explore the various limitations and challenges faced in utilizing this tool, and discuss alternative investigations commonly used to supplement it for risk stratification.

Intelligence-led policing in the 21 Century: How increased mobility requires new paradigms of information sharing.

The challenge posed by mobile criminality to law enforcement has increased in the 21 Century, as technology and digital communication have accelerated. This study examines the threat by analysing foreign national suspects data (arrested in a UK police force, n = 293) and UK-based practitioner interviews (n = 36). The evidence reveals the threat from offenders who travel between countries is growing, in quantity and sophistication.

Evaluation of Autograft Contamination in Anterior Cruciate Ligament Reconstruction and Its Clinical Impact: A Systematic Review and Meta-Analysis.

Background: Understanding the characteristics of intraoperative graft contamination (IOGC) in anterior cruciate ligament reconstruction (ACLR) may guide infection control measures. Our aim was to determine the rate and characteristics of IOGC during ACLR and its clinical impact in relation to the development of postoperative infection.

Methods: A systematic review and meta-analysis using Cochrane methodology were performed.

Reproductive capital: theoretical foundations and empirical evidence from the workplace.

Introduction: The workplace encompasses structural and personal tensions related to both reproduction and non-reproduction, as well as ambiguity and ambivalence permeate policies, practices, and social interactions. The aim of this study was to explore and record participants' diverse fertility journeys and the effect of work on their preconception/infertility experience.

Method: The concept of "reproductive capital" emerged from a latent thematic analysis of semi-structured bio-narrative interviews with 80 people (67 women and 13 men) and their accounts of how the workplace affected their reproductive journeys.

Scorpion (Hottentotta tamulus) venom pre-exposure delays functional recovery in mice following peripheral nerve injury.

Scorpion sting leads to profound challenges of central nervous system (CNS) impairments such as neuro-inflammation, unconsciousness, aberrant ion channels physiology, epilepsy and may become fatal due to heart failure. However persistence of Hottentotta tamulus venom in peripheral nerves and subsequent influence on regenerative process of injured peripheral nerve remains unknown. Current study reports the persistence of H.

A narrative inquiry of men's perceptions of support and masculinity: semi-structured interviews of men living with non-cancer-related lymphoedema in the United Kingdom.

Background: Lymphoedema, a chronic and visible condition, can significantly impact men's perception of support and masculinity. The absence of research in this area, along with increased interest in men's health, led to this study, which explores men's perceptions of support and their sense of masculinity while living with lymphoedema.

Method: This qualitative study used narrative inquiry with 12 participants through online semi-structured interviews (45-90 minutes) via Zoom.

Nafion in Biomedicine and Healthcare.

Nafion has long been recognized as the gold standard for proton exchange membranes, due to its exceptional ion exchange capacity and its advanced performance in chemically aggressive environments. In recent years, a growing body of evidence has demonstrated that Nafion is equally well-suited in complex biological conditions owing to its structural robustness, responsive functionality and intrinsic biocompatibility. These characteristics have enabled its transition into the biomedical and healthcare sectors, where it is currently being explored for a diverse and expanding range of applications.

Childbirth Experiences in the United Kingdom Compared to the Netherlands: A Cross-Sectional Survey Study.

Introduction: This study was performed to compare childbirth experiences in the United Kingdom (UK) and the Netherlands (NL) and identify determinants of positive childbirth experiences in both countries.

Methods: Women who gave birth in the UK (n = 1303) or the NL (n = 900) between January 2017 and December 2020 who filled in the cross-sectional Babies Born Better survey were included in this study. Fully adjusted logistic regression models were used to assess differences in the odds of a positive childbirth experience between the two countries.

Global variations in omega-3 fatty acid status and omega-6:omega-3 ratios: insights from > 500,000 whole-blood dried blood spot samples.

Omega-3 (n-3) fatty acids are critical for human health, with the omega-6 (n-6) to n-3 fatty acid ratio and the omega-3 levels recognized as contributing to the risk of many chronic non-communicable diseases. Direct measurement of fatty acid levels in blood provides the most accurate assessment of fatty acid status and balance, with fingertip dried blood spot (DBS) analysis offering a practical and cost-effective assessment method. This study analyses more than 590,000 globally sourced DBS samples, providing fatty acid profiles in whole blood across diverse populations.

Speech Disfluencies and Hand Gestures as Metacognitive Cues.

How language interacts with metacognitive processes is an understudied area. Earlier research shows that people produce disfluencies (i.e.

Does the Eccentric Strength Profile of the Hamstrings Determine the Severity of Injury Sustained?

Background And Purpose: Understanding how strength profiles of footballers effect the extent or location of injury sustained is limited. The purpose of this study was to investigate the effect of eccentric hamstrings strength (EHS), on the resultant injury sustained, graded utilizing the British Athletic Muscle Injury Classification, diagnosed via MRI.

Methods: EHS of 95 professional footballers were assessed on match-day minus two (MD-2) and plus two (MD+2).