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Angulatin F (1) and angulatin I (2), two new sesquiterpene polyol esters, were isolated from the root barks of Celastrus angulatus, together with six known compounds 1β,2β-diacetoxy-4α,6α-dihydroxy-8α-isobutanoyloxy-9β-benzoyloxy-15-(α-methyl) butanoyloxy-β-dihydroagrofuran (3), angulatin A (4), angulatin B (5), celangulatin E (6), 1β,2β,15-triacetoxy-4α,6α-dihydroxy-8α-isobutanoyloxy-9β-benzoyloxy-β-dihydroagrofuran (7), and celangulin I (8). The structures of 1 and 2 were elucidated as 1β,2β,6α,15-tetraacetoxy-4α-hydroxy-8β,9α-difuroyloxy-β-dihydroagrofuran and 1β,2β,6α,8β,15-pentaacetoxy-4α-hydroxy-9β-furoyloxy-β-dihydroagrofuran by spectroscopic means.
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http://dx.doi.org/10.1080/10286020.2011.555332 | DOI Listing |
J Agric Food Chem
April 2025
The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
(-)-α-Bisabolol is one of the important derivatives in the mevalonate (MVA) pathway. Yeast not only possesses a complete MVA metabolic pathway but also has mature modification and optimization strategies, among which transcription factor regulation is a very effective method. In this study, by screening transcription factors associated with the MVA pathway, a new regulatory factor, ECM22, was discovered that can be used for terpenoid synthesis, and ECM22 proved to be the most effective compared to other screened transcription factors.
View Article and Find Full Text PDFNat Prod Res
October 2024
Key Laboratory of Natural Products and High & New Technology Research Center, Henan Academy of Science, Zhengzhou, China.
Three new sesquiterpene polyol ester compounds angulatin V [1,15-diacetoxy-2-(α-methyl)-butanoyloxy-4α,6α-dihydroxy-8α-isobutanoyloxy-9-benzoxy--dihydroagarofuran], angulatin W [1,2-diacetoxy-4α,6α-dihydroxy-8-carbonyl-9-benzoxy-15-isobutanoyloxy--dihydroagarofuran], angulatin X [1,28α-triacetoxy-4α, 6α-dihydroxy-9-benzoxy-15-nicotinyl--dihydroagarofuran] (), together with one known compound Putterine B (), were isolated from the root bark of Maxim. The structures of compounds were elucidated by NMR, HRESIMS, IR data, and comparison with the literature data. The anti-inflammatory activity of all compounds was evaluated by measuring nitric oxide production in RAW264.
View Article and Find Full Text PDFJ Agric Food Chem
July 2024
College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, P. R. China.
Chin J Nat Med
March 2023
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 511436, China. Electronic address:
The stem and branch extract of Tripterygium wilfordii (Celastraceae) afforded seven new dihydroagarofuran sesquiterpene polyesters [tripterysines A-G (1-7)] and eight known ones (8-15). The chemical structures of these new compounds were established based on combinational analysis of HR-ESI-MS and NMR techniques. The absolute configurations of tripterysines A-C (1-3) and E-G (5-7) were determined by X-ray crystallographic analysis and circular dichroism spectra.
View Article and Find Full Text PDFMolecules
January 2023
"Annalaura Segre" Magnetic Resonance Laboratory, Institute for Biological Systems, CNR, Via Salaria, Km 29,300, 00015 Monterotondo, Italy.
The recovery of bioactive compounds from crop byproducts leads to a new perspective way of waste reutilization as a part of the circular economy. The present study aimed at an exhaustive metabolite profile characterization of globe artichoke and cauliflower byproducts (leaves, stalks, and florets for cauliflower only) as a prerequisite for their valorization and future implementations. The metabolite profile of aqueous and organic extracts of byproducts was analyzed using the NMR-based metabolomics approach.
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