Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The aim of this study was to investigate the ability of ultrasound (US) techniques to monitor the swelling behaviour of hydrophilic polymer matrix tablets. Tablets were prepared from hydroxypropyl methylcellulose (HPMC) and polyethylene oxide (PEO) polymers. The movement of the eroding front was investigated with ultrasound scanning techniques on each tablet's outer interface during tablet immersion in phosphate buffer (PB). In addition, a US window technique was utilized to simultaneously evaluate eroding and swelling front movements during the tablet dissolution process. An optical monitoring was used as the reference method. The focused pulsed echo ultrasound method was found to be applicable for evaluating the swelling process of hydrophilic polymer matrix tablets. Furthermore, it was noted that the sensitivity to follow hydrogel formation and thickening by US monitoring varied depending on the polymer under study. Thus, multifront detection is challenging since the hydrogels formed by different polymers may have totally different acoustic properties. It was found that the microbubbles formed inside the hydrogel were acting as a "contrast agent", characteristic of some polymers during immersion. In spite of these challenges, the US window technique introduced in this study was proven to be a promising method for simultaneous multifront detection.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2010.11.026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oxygen-Tolerant, Red Light-Driven Controlled Synthesis of Easily Degradable and High Molecular Weight α-Lipoic Acid-Vinyl Copolymers.
Angew Chem Int Ed Engl
September 2025
Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA, 15213, USA.
α-Lipoic acid (LA) has recently emerged as an attractive, inexpensive monomer for synthesizing degradable polymers via ring-opening of its 1,2-dithiolane, introducing easily cleavable disulfide linkages into polymer backbones. Reversible addition-fragmentation chain transfer (RAFT) copolymerization with vinyl monomers enables access to degradable poly(disulfide)s with controlled molecular weights. However, conventional thermal RAFT methods suffer from oxygen sensitivity, limited LA incorporation (<40 mol%), and modest degrees of polymerization (DP < 300).
View Article and Find Full Text PDFHigh-strength and water resistance polyvinyl alcohol fibers modified with lignin nanoparticles and boron nitride nanosheets@hyperbranched polylysine.
Int J Biol Macromol
September 2025
Department of Design and Merchandising, College of Health and Human Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Development on sustainable and inexpensive polymer fibers with high mechanical and water resistance properties has garnered significant attention in infrastructure application. Herein, lignin nanoparticles (LNP) were used as a modifier, boron nitride nanosheets (BNNS)@hyperbranched polylysine (HBPL) obtained were regarded as the cooperative modifier, and then polyvinyl alcohol (PVA)/LNP/BNNS@HBPL composite fibers were fabricated successfully by wet and dry spinning. Vast free hydrophilic hydroxyl groups in PVA decreased due to hydrogen bonding interactions among LNP, BNNS@HBPL, and PVA, thereby attenuating intramolecular and intermolecular hydrogen bonding within PVA.
View Article and Find Full Text PDFA covalent organic polymer fluorescent probe for highly selective and sensitive UO detection in water and food samples.
Biosens Bioelectron
September 2025
Cancer Research Institute, The First Affiliated Hospital, University of South China, Hengyang, 421001, PR China; State Key Laboratory of Chemo/Biosensing and Chemometrics, School of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China. Electronic address:
A highly sensitive, selective, and simple method for detecting uranyl ions (UO) is crucial for human health and environmental safety. Amidoxime-based nanomaterials have been widely employed for UO detection, but their higher affinity for vanadium than UO limits their practical applications. Herein, a novel covalent organic polymer fluorescent probe (TT-COP) for UO detection was innovatively developed by a one-step Schiff-base condensation reaction between 3,3',5,5'-tetramethylbenzidine (TMB) and 2,4,6-triformylphloroglucinol (Tp).
View Article and Find Full Text PDFMolecular Insights into the Reversible Mechanisms of CO-Switchable Surfactant Solubilization and Emulsification.
Langmuir
September 2025
Polymer Research Institute, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China.
Switchable surfactants exhibit broad application potential due to their reversible response to external stimuli. The reversible mechanism of the CO-switchable surfactant ('-dodecyl-, -dimethyl-acetamidines, DDA) solubilization polycyclic aromatic hydrocarbons (PAHs) and the microscopic dynamic behavior of emulsification/demulsification were systematically studied using coarse-grained molecular dynamics simulations. The dynamic transition processes of protonation (DDA to DDA) and deprotonation (DDA to DDA) were successfully simulated.
View Article and Find Full Text PDFA Facile and Efficient Route to Achieve Polythiophene-Based Nanoparticles With Various Morphologies.
Angew Chem Int Ed Engl
September 2025
Key Laboratory of Hebei Province for Molecular Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300401, P.R. China.
Polythiophene-based nanoparticles (PTNPs), a prominent class of conjugated polymer nanoparticles (CPNs) with remarkable optical and electronic properties, have gained significant attention in applications such as electronics and bioimaging. However, current methods in generating PTNPs have run into obstacles including low variety of morphologies, poor reproducibility, and low preparation efficiency, restricting their further application. In this study, we report a facile and efficient fabrication strategy based on template synthesis method.
View Article and Find Full Text PDF