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Study Design: Displacement-controlled finite element analysis was used to evaluate the mechanical behavior of the lumbar spine after insertion of the Dynesys dynamic stabilization system.
Objective: This study aimed to investigate whether different depths of screw placement of Dynesys would affect load sharing of screw, range of motion (ROM), annulus stress, and facet contact force.
Summary Of Background Data: In clinical follow-up, a high rate of screw complications and adjacent segment disease were found after using Dynesys. The pedicle screw in the Dynesys system is not so easy to implant into the standard position and causes the screw to protrude more prominently from the pedicle. Little is known about how the biomechanical effects are influenced by the Dynesys screw profile.
Methods: The Dynesys was implanted in a 3-dimensional, nonlinear, finite element model of the L1 to L5 lumbar spine. Different depths of screw position were modified in this model by 5 and 10 mm out of the pedicle. The model was loaded to 150 N preload and controlled the same ROMs by 20, 15, 8, and 20 degrees in flexion, extension, torsion, and lateral bending, respectively. Resultant ROM, annulus stress, and facet contact force were analyzed at the surgical and adjacent level.
Results: Under flexion, extension, and lateral bending, the Dynesys provided sufficient stability at the surgical level, but increased the ROM at the adjacent level. Under flexion and lateral bending, the Dynesys alleviated annulus stress at the surgical level, but increased annulus stress at the adjacent level. Under extension, the Dynesys decreased facet loading at the surgical level but increased facet loading at the adjacent level.
Conclusions: This study found that the Dynesys system was able to restore spinal stability and alleviate loading on disc and facet at the surgical level, but greater ROM, annulus stress, and facet loading were found at the adjacent level. In addition, profile of the screw placement caused only a minor influence on the ROM, annulus stress, and facet loading, but the screw stress was noticeably increased.
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http://dx.doi.org/10.1097/BSD.0b013e3181b63d89 | DOI Listing |
Bone Joint Res
September 2025
Department of Orthopedics, Luzhou Key Laboratory of Orthopedic Disorders, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Aims: Intervertebral disc degeneration (IDD) and sagittal-oriented articular processes can restrict motility and increase stiffness of the motion segment, potentially causing compensatory stress and higher motility in adjacent segments. It is unclear if these factors trigger IDD progression in adjacent segments. This study aimed to elucidate this using functional MRI, and identify biomechanical mechanisms with a validated numerical model.
View Article and Find Full Text PDFSheng Wu Yi Xue Gong Cheng Xue Za Zhi
August 2025
Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, P. R. China.
The lumbar intervertebral disc exhibits a complex physiological structure with interactions between various segments, and its components are extremely complex. The material properties of different components in the lumbar intervertebral disc, especially the water content (undergoing dynamic change as influenced by age, degeneration, mechanical loading, and proteoglycan content) - critically determine its mechanical properties. When the lumbar intervertebral disc is under continuous pressure, water seeps out, and after the pressure is removed, water re-infiltrates.
View Article and Find Full Text PDFClin Spine Surg
August 2025
Shi's Center of Orthopedics and Traumatology (Institute of Orthopaedics and Traumatology, Shanghai Academy of Traditional Chinese Medicine), Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine.
Study Design: Finite element (FE) comparative study.
Objective: This study aims to assess the biomechanical effects of Chinese manual therapy (CMT) on the cervical spine following percutaneous endoscopic cervical foraminotomy and diskectomy (PECFD).
Summary Of Background Data: Cervical spondylotic radiculopathy (CSR) is a challenging condition that often recurs after cervical spine surgery, sparking interest in alternative treatment modalities such as CMT.
Int J Mol Sci
July 2025
Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos", 153 41 Athens, Greece.
Doxorubicin (DOX) is widely used for the treatment of several tumors, but considerable dose-dependent side effects on many normal tissues, including bones, have been reported. The aim of the present study was to follow for the first time the kinetics of DOX accumulation/clearance in the non-vascularized intervertebral disc (IVD), as well as to assess the drug's biological action in the annulus fibrosus (AF) and nucleus pulposus (NP) IVD cells and tissues. DOX was administered intravenously to rabbits before the isolation of IVDs, in which DOX quantification was performed using a highly sensitive LC-HRMS/MS analytical method.
View Article and Find Full Text PDFFront Bioeng Biotechnol
July 2025
Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: The high rate of retear following rotator cuff repair is largely attributed to the absence of a fibrocartilage layer and limited bone regeneration capacity. We aim to evaluate a bioadhesive derived from decellularized porcine annulus fibrosus extracellular matrix, loaded with zeolitic imidazolate framework-8 (ZIF-8), and to promote rotator cuff tendon-bone healing.
Methods: Three adhesive formulations were developed: (1) silk fibroin/tannic acid (ST group), (2) ST combined with decellularized porcine annulus fibrosus extracellular matrix (ST/dECM group), and (3) ST/dECM supplemented with ZIF-8 (ST/dECM/ZIF-8 group).