Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To quantitatively summarize the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases.
Methods: We surveyed studies on the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed in a fixed/random effect model.
Results: We identified 14 studies using a PubMed search. Meta-analysis was performed for NFKBIA gene polymorphisms at positions 2758 (A/G, 5 studies), -881 (A/G, 3 studies), -826 (C/T, 3 studies), and -297 (C/T, 3 studies). We did not detect associations of NFKBIA gene polymorphisms at positions 2758, -881, -297 with autoimmune and inflammatory diseases. An association of NFKBIA gene -826C/T polymorphism with autoimmune and inflammatory diseases was found (C vs. T: OR = 1.81, 95% CI = 0.97-3.36, P = 0.06; CT + TT vs. CC: OR = 2.11, 95% CI = 1.07-4.19, P = 0.03; TT vs. CC + CT: OR = 2.20, 95% CI = 0.78-6.21, P = 0.06; TT vs. CC: OR = 2.87, 95% CI = 0.78-10.62, P = 0.11; CT vs. CC: OR = 2.02, 95% CI = 1.22-3.36, P = 0.006).
Conclusion: This meta-analysis demonstrates that autoimmune and inflammatory diseases are associated with NFKBIA gene -826C/T polymorphism, but not with 2758A/G, -881A/G, and -279C/T.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00011-010-0216-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unveiling the mechanism of Pogostemon cablin (Blanco) Benth in treating heat illnesses via network pharmacology and molecular simulation.
PLoS One
September 2025
Department of Emergency Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Background: Heat illness is a dangerous condition marked by a widespread inflammatory response. Although Pogostemon cablin (Blanco) Benth and its derivatives are clinically used, their mechanisms remain unclear.
Methods: 11 heat illness patients and 14 healthy volunteers from Southwest Medical University Affiliated Hospital were enrolled.
Reduced circulating regulatory T cells in primary Sjögren's syndrome: the contribution of enhanced apoptosis and impaired survival.
Front Immunol
September 2025
Division of Rheumatology, Department of Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Background: Regulatory T cells (Tregs) are found to be critical for maintaining immune tolerance to self-antigens; however, their status in primary Sjögren's syndrome (pSS) remains unclear. We investigated alterations in the abundance of peripheral Tregs in a large pSS cohort and their implications for patients.
Methods: Levels of CD4+CD25+FOXP3+Treg cells in the peripheral blood of 624 patients with pSS, and 93 healthy controls (HCs) were detected using modified flow cytometry (FCM).
Bone marrow immune remodeling in depression: TNF/NF-κB mediated leukocyte redistribution and construction of an interpretable predictive model.
Int Immunopharmacol
September 2025
Hebei Medical University Postdoctoral Research Station in Basic Medicine, No. 361 Zhongshan Dong Road, 050017 Shijiazhuang, China; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, College of Forensic Medicine, Hebei Medical Univ
Environmental stress contributes to the development of depression through neuro-immune interactions, yet the underlying molecular mechanisms and associated clinical diagnostic biomarkers remain unclear. We established a psychosocial stress mouse model and systematically investigated the immune dysregulation induced by stress through integrated analysis of blood cell profiles, leukocyte transcriptomics, protein-protein interaction networks, single-cell RNA sequencing, and targeted pharmacological intervention. Additionally, we constructed and validated a depression predictive model using multiparametric peripheral blood data and machine learning, and assessed feature importance using the SHapley Additive exPlanations (SHAP) analysis.
View Article and Find Full Text PDFImmunophenotyping and Mutation Analysis of Canine Intestinal T-Cell Lymphoma: A Comparative Pathological Study of Human Enteropathy-Associated T-Cell Lymphoma.
Vet Comp Oncol
August 2025
Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Human enteropathy-associated T-cell lymphoma (EATL) is a rare primary aggressive intestinal T-cell lymphoma associated with celiac disease and is considered to be a neoplasm of intraepithelial lymphocytes (IELs) with an innate lymphoid cell (ILC)-like immunophenotype. The lack of an animal model has delayed the elucidation of its pathogenesis. In dogs, the histopathological and immunophenotypic features of intestinal large T-cell lymphoma (ILTCL) are similar to EATL; however, its cell of origin remains unclear.
View Article and Find Full Text PDFIdentification and validation of oxidative stress signature genes in the trabecular meshwork of glaucoma.
Sci Rep
August 2025
Department of Anatomy and Neurobiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, 410013, China.
Oxidative stress (OS) plays an important role in trabecular meshwork (TM) dysfunction in glaucoma, but its molecular mechanism remains unclear. We integrated the GSE27276 dataset and OS-related gene sets from GeneCards to screen 61 differentially expressed OS-related genes (DEOSGs). Functional enrichment analysis revealed that these genes are primarily involved in inflammatory and OS-related signaling pathways, including IL-17, TNF, and NF-κB.
View Article and Find Full Text PDF