Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Legionella pneumophila, the intracellular bacterial pathogen that causes Legionnaires' disease, exhibit characteristic transmission traits such as elevated stress tolerance, shortened length and virulence during the transition from the replication phase to the transmission phase. ClpP, the catalytic core of the Clp proteolytic complex, is widely involved in many cellular processes via the regulation of intracellular protein quality.
Results: In this study, we showed that ClpP was required for optimal growth of L. pneumophila at high temperatures and under several other stress conditions. We also observed that cells devoid of clpP exhibited cell elongation, incomplete cell division and compromised colony formation. Furthermore, we found that the clpP-deleted mutant was more resistant to sodium stress and failed to proliferate in the amoebae host Acanthamoeba castellanii.
Conclusions: The data present in this study illustrate that the ClpP protease homologue plays an important role in the expression of transmission traits and cell division of L. pneumophila, and further suggest a putative role of ClpP in virulence regulation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838875 | PMC |
| http://dx.doi.org/10.1186/1471-2180-10-54 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.
Mol Psychiatry
September 2025
Department of Psychology, Seoul National University, Seoul, South Korea.
A family history of depression is a well-documented risk factor for offspring psychopathology. However, the genetic mechanisms underlying the intergenerational transmission of depression remain unclear. We used genetic, family history, and diagnostic data from 11,875 9-10 year-old children from the Adolescent Brain Cognitive Development study.
View Article and Find Full Text PDFPrevalence and Antimicrobial Resistance Patterns of Escherichia coli Isolated From Broiler Chickens in Sylhet District of Bangladesh.
Vet Med Sci
September 2025
Department of Pharmacology and Toxicology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, Bangladesh.
The emergence of antimicrobial resistance (AMR) Escherichia coli in poultry farming is a growing global public health concern, particularly in Bangladesh, where the use of antibiotics remains largely unregulated. This study aimed to determine the prevalence and AMR patterns of E. coli isolated from broiler chickens in Sylhet district of Bangladesh and to investigate the network of coexisting resistance traits among the isolates.
View Article and Find Full Text PDFPedigree analysis and dermatoglyphic features of probands with schizophrenia and their affected gender-matched parents: A cross-sectional comparative study.
Indian J Psychiatry
August 2025
Epidemiology, School of Public Health, SRM University, Sikkim, India.
Background: The role of sex chromosomes in transmission of schizophrenia may be revealed by studies of phenotypic characteristics.
Aim: To explore variations in dermatoglyphic parameters between probands with schizophrenia and their respective affected gender-matched parents, with unaffected controls.
Methods: The difference of the absolute finger ridge counts (AFRC) and occurrence of identical finger patterns between the male probands and their affected fathers (n = 12) was compared with that of female probands and their affected mothers (n = 15).
Multi-omics and experimental validation reveal the mechanism of DanxiaTiaoban decoction in treating atherosclerosis.
Phytomedicine
August 2025
Cardiology Department, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China. Electronic address:
Background: Atherosclerosis (AS) is a leading risk factor for cardiovascular diseases globally, characterised by the accumulation of lipids and cholesterol in arterial walls, causing vascular narrowing and sclerosis along with chronic inflammation; this leads to increased risk of heart disease and stroke, significantly impacting patients' health. Danxia Tiaoban Decoction (DXTB), a traditional Chinese medicine (TCM) formula, has demonstrated positive clinical effects in treating AS; however, its mechanisms of action remain unclear.
Objective: To explore the potential mechanisms of action of DXTB in treating AS through multi-omics integration and experimental validation.
Modification of starch traits in commercial wheat through TaWaxy gene editing.
Carbohydr Polym
November 2025
State Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address:
Amylose content (AC) is a key determinant of wheat quality, and the TaWaxy gene determined amylose synthesis with a dose-dependent effect on AC. In this study, the TaWOX5 gene, which significantly enhances wheat transformation efficiency, was combined with CRISPR/SpCas9 system to generate TaWaxy mutants in a commercial winter wheat Jimai 22. Seven transgene-free mutant types were produced, compared to only three transgene-free mutants in the spring wheat variety Ningchun 4.
View Article and Find Full Text PDF