Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Twelve patients with locally advanced esophageal squamous cell carcinoma were enrolled to evaluate the safety and efficacy of concurrent chemo-radiotherapy. Dose-limiting toxicity was mainly observed at Capecitabine 1500 mg. The maximum-tolerated dose/recommended dose of Capecitabine was 1000 mg. The Kaplan-Meier estimated overall l-year survival rate was 100%.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2009.08.002DOI Listing

Publication Analysis

Top Keywords

locally advanced
8
advanced esophageal
8
esophageal squamous
8
squamous cell
8
cell carcinoma
8
phase study
4
study concurrent
4
concurrent selective
4
selective lymph
4
lymph node
4

Similar Publications

Ni-Fe (oxy)hydroxides are among the most active oxygen evolution reaction (OER) catalysts in alkaline media. However, achieving precise control over local asymmetric Fe-O-Ni active sites in Ni-Fe oxyhydroxides for key oxygenated intermediates' adsorption steric configuration regulation of the OER is still challenging. Herein, we report a two-step dealloying strategy to fabricate asymmetric Fe-O-Ni pair sites in the shell of NiOOH@FeOOH/NiOOH heterostructures from NiFe Prussian blue analogue (PBA) nanocubes, involving anion exchange and structure reconstruction.

View Article and Find Full Text PDF

Background: Sarcomas are rare cancer with a heterogeneous group of tumors. They affect both genders across all age groups and present significant heterogeneity, with more than 70 histological subtypes. Despite tailored treatments, the high metastatic potential of sarcomas remains a major factor in poor patient survival, as metastasis is often the leading cause of death.

View Article and Find Full Text PDF

Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in developing countries, where access to early diagnosis, comprehensive care, and research infrastructure is limited. This article synthesizes the insights generated during a Fireside Chat convened by members of the Latin American Cooperative Oncology Group (LACOG)-Head and Neck and the Brazilian Group of Head and Neck Cancer (GBCP), with the participation of international expert Professor Hisham Mehanna. The discussion addressed key challenges and opportunities in clinical and translational research within resource-constrained settings.

View Article and Find Full Text PDF

Two-dimensional (2D) materials offer a valuable platform for manipulating and studying chemical reactions at the atomic level, owing to the ease of controlling their microscopic structure at the nanometer scale. While extensive research has been conducted on the structure-dependent chemical activity of 2D materials, the influence of structural transformation during the reaction has remained largely unexplored. In this work, we report the layer-dependent chemical reactivity of MoS during a nitridation atomic substitution reaction and attribute it to the rearrangement of Mo atoms.

View Article and Find Full Text PDF

Background: Current aftercare in breast cancer survivors aims to detect local recurrences or contralateral disease, while the detection of distant metastases has not been a central focus due to a lack of evidence supporting an effect on overall survival. However, the data underpinning these guidelines are mainly from trials of the 1980s/1990s and have not been updated to reflect the significant advancements in diagnostic and therapeutic options that have emerged over the past 40 years. In this trial, the aim is to test whether a liquid biopsy-based detection of (oligo-) metastatic disease at an early pre-symptomatic stage followed by timely treatment can impact overall survival compared to current standard aftercare.

View Article and Find Full Text PDF