A systematic review on oncological outcomes, functional results, and laryngeal preservation in vertical partial laryngectomies vs. transoral laser microsurgery for early stage glottic cancer.

Purpose: To compare the oncological and functional outcomes of transorallaser microsurgery (TLM) and vertical partial laryngectomy (VPL) in earlystageglottic carcinoma (T1-T2).

Methods: A systematic review following PRISMA guidelines analyzedcomparative studies from 2000 to 2024 in PubMed, EMBASE, and Web ofScience. Outcomes included local control, recurrence rates, larynxpreservation, survival, voice quality, and complications.

Metabolic Heterogeneity Confers Differences in the Tumor Microenvironment of Aggressive Types of Melanomas.

Background: Melanoma affects skin and mucosa and can be particularly aggressive when the lesion is an advanced cutaneous tumor or located in the sinonasal or oral mucosa. Reprogramming of energy metabolism has been defined as a hallmark of cancer; so this study aimed to verify the expression of proteins related to metabolism and cellular proliferation.

Methods: Immunohistochemical analysis with antibodies adipophilin, FASN, GLUT-1, HIF-1α, and Ki-67 was performed in a series of 28 sinonasal melanomas (SM), 16 oral melanomas (OM), and 39 cutaneous melanomas (CM).

Exploring TROP2 expression in oropharyngeal squamous cell carcinoma: Association with prognosis and tumor immune microenvironment composition.

Oropharyngeal squamous cell carcinoma (OPSCC) presents prognostic and therapeutic challenges. Trophoblast cell surface antigen 2 (TROP2) is a transmembrane glycoprotein involved in oncogenic signaling pathways and has been explored as a therapeutic target in many solid tumors. This study aims to evaluate the prevalence and prognostic significance of TROP2 expression in OPSCC and explore its association with the tumor immune microenvironment composition.

Survival patterns and prognostic stratification based on distant metastasis characteristics in oral squamous cell carcinoma.

Aim: Despite advances in the treatment of oral squamous cell carcinoma (OSCC), distant metastasis (DM) remains a major obstacle to improving its prognosis. This study aimed to predict survival based on DM characteristics and to detail related outcomes.

Methods: We conducted a multicenter retrospective cohort of patients diagnosed with OSCC and treated at two centers.

Prognostic Significance of Solid Subtype of Papillary Thyroid Carcinoma: Analysis of 63 Patients.

Objective: Solid subtype of papillary thyroid carcinoma (SSPTC) is an uncommon subtype of papillary thyroid cancer (PTC) and its prognostic significance is still controversial. The aim of this review is to present the clinicopathological features of SSPTC and compare its clinical behavior with classical PTC (cPTC).

Methods: We retrospectively analyzed patients who underwent thyroidectomy for SSPTC and compared the clinicopathological findings and clinical outcomes with those of patients with cPTC.

MicroRNA Profiles Distinguishing Metastatic from Non-Metastatic Salivary Mucoepidermoid Carcinoma.

Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. Metastatic spread occurs in up to 80% of high-grade tumors; however, the mechanisms underlying this process are largely unknown. Large-scale microRNA (miRNA) expression profiling studies of human cancers have demonstrated that dysregulation of miRNA is frequently associated with many cancer types.

Transoral robotic thyroidectomy using Versius platform: a preclinical feasibility study in cadavers.

Remote-access thyroidectomy techniques have been developed to address esthetic concerns related to cervical scarring following conventional thyroidectomy. Transoral robotic thyroidectomy offers a scarless vestibular access combined with the technological advantages of robotic systems. To date, only the Da Vinci platform has been clinically utilized for this procedure.

Bone-remodeling-related gene expression in oral squamous cell carcinoma: impact on mandibular invasion and overall survival.

Objectives: Bone invasion by oral squamous cell carcinoma (OSCC) activates the remodeling process with the participation of RANK/RANKL/OPG and Interleukin 6 (IL-6) genes. This study aimed to evaluate gene expressions of RANK, RANKL, OPG, and IL-6 in OSCC associated with mandibular invasion (MI) and to identify their influence on patients' overall survival (OS).

Materials And Methods: A cross-sectional study selected patients treated with mandibulectomy for OSCC in a reference center, resulting in two hundred and twenty individuals.

Automated classification of oral potentially malignant disorders and oral squamous cell carcinoma using a convolutional neural network framework: a cross-sectional study.

Background: Artificial Intelligence (AI) models hold promise as useful tools in healthcare practice. We aimed to develop and assess AI models for automatic classification of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) clinical images through a Deep Learning (DL) approach, and to explore explainability using Gradient-weighted Class Activation Mapping (Grad-CAM).

Methods: This study assessed a dataset of 778 clinical images of OPMD and OSCC, divided into training, model optimization, and internal testing subsets with an 8:1:1 proportion.

Validation of a New Histopathologic Risk Model in Early Oral Tongue Cancer: A Combination of a Modified Worst Pattern of Invasion and a New Tumor Budding Score.

Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity. A new histopathologic risk assessment has been recently introduced and we sought to validate its prognostic value in a large multicenter cohort of early-stage OTSCC. A total of 310 cases treated for early-stage OTSCC were included in this study.

Overview of care for head and neck Cancer cases in Brazilian Cancer Centers during the COVID-19 pandemic.

Objective: To assess the impact of the COVID-19 pandemic on Brazilian Head and Neck (H&N) oncology reference services.

Methods: This cross-sectional study evaluated data on the number of outpatient consultations, operations and infected physicians collected in 13 Brazilian Cancer Centers.

Results: 10% of the H&N surgeons had COVID-19 infection.

Assessing user experience with services: measuring subjective well-being in oncology hospitals.

Background: Capturing subjective user experiences is crucial for service design, assessment, and management. However, using metrics for such experiences remains an underexplored topic in the literature. This study introduces a novel survey tool to measure service-related subjective well-being (SWB) among oncology patients, encompassing the three dimensions of SWB: positive affect, negative affect, and life satisfaction.

Epithelial-myoepithelial carcinoma: Retrospective analysis of the case series from a reference center in São Paulo, Brazil.

Objective: Given the recent increase in diagnoses in our service, a referral center in São Paulo, this study aims to analyze the case series at this center and compare it with the existing literature. The objective is to comprehend the characteristics and prognosis of this disease and provide insights to enhance its treatment.

Methods: Confirmed cases of EMC were selected at the Hospital das Clínicas da FMUSP between 2011 and 2021.

Metastatic basal cell carcinoma: Case series and literature review.

Objective: To present a metastatic head and neck basal cell carcinoma (BCC) series treated by a university teaching service between 1993 and 2021.

Methods: A review of medical records of 500 patients with high-risk BCC in the head and neck was performed. Tumors with a diameter greater than or equal to 6 mm in the "H" area of the face or greater than 10 mm in other head and neck areas; recurrences; sclerodermiform, micronodular and metatypical subtypes; and perineural invasion were considered factors indicating high-risk.

Surgical Management of Retropharyngeal Metastases From Papillary Thyroid Carcinoma: Transcervical and Transoral Robotic Approaches.

Background: Papillary thyroid carcinoma (PTC) typically has favorable outcomes, with surgery as the primary treatment. While metastases to central or lateral cervical lymph nodes are relatively common, retropharyngeal spread is rare. It often manifests as elevated serum thyroglobulin levels or iodine uptake in recurrent disease in asymptomatic patients.

Oncologic outcomes of microscopic tumor cut through in locally advanced oral squamous cell carcinoma.

Objective: This study aims to determine the impact of MTCT on local recurrence and disease-specific survival in patients with locally advanced T3-T4 OCSCC and compare it with other clinicopathological variables.

Methods: A retrospective database analysis of patients diagnosed with locally advanced T3-T4 OCSCC surgically treated and submitted to intraoperative frozen section guiding the margin status. Survival was analyzed using the Kaplan-Meier estimator followed by the Cox model for multivariate analysis.

Preoperative neoadjuvant chemotherapy or immunotherapy in head and neck cancer: A systematic review and meta-analysis of surgical risk and pathologic response.

Objective: This systematic review and meta-analysis aimed to evaluate surgical complications, pathologic responses, and disease progression in patients with head and neck squamous cell carcinoma treated with neoadjuvant chemotherapy or immunotherapy.

Methods: A comprehensive literature search was conduct across four databases (PubMed, Embase, Cochrane Library, and Scopus) and grey literature sources to identify neoadjuvant therapies in head and neck cancer patients. Only prospective clinical trials were included.

Development of an extratracheal device for pulmonary function assessment in laryngectomized patients.

Purpose: Pulmonary function assessment in laryngectomized patients is challenging due to technical difficulties in performing spirometry. Existing methods have limitations, including potential air leakage and patient discomfort. The purpose of this study was to develop a simple, comfortable extratracheal device for accurate pulmonary function assessment in laryngectomized patients.

Older Patients with Head and Neck Cancer: A Scoping Review of Differences Regarding Diagnosis and Outcomes.

Background: Understanding the relationship between age and diagnostic challenges, as well as outcomes in older patients with head and neck cancer, is crucial. The significance of age as a prognostic factor and how it should influence treatment decisions is debated, highlighting the need for tailored insights to help physicians make more informed choices.

Objective: This scoping review aims to address the diagnostic challenges/differences and patient outcomes as infection, pain, treatment-related complications (either postmedical or postoperative), treatment toxicities, disease control, morbidity, and/or survival/mortality in older patients (above the cut-off age of 60 years) with head and neck cancer.

Predictive factors for permanent hypoparathyroidism following total thyroidectomy: A retrospective cohort study of 5,671 cases.

Objective: To evaluate the rates of permanent hypoparathyroidism based on demographic variables, patient comorbidities, clinical staging of the disease, surgery performed, and severity of transient hypoparathyroidism.

Subjects And Methods: This is a retrospective cohort study with patients who underwent total thyroidectomy with or without neck dissection between January 2014 and December 2021.

Results: 5,671 patients were analyzed, 966 (17)%) presented transient hypoparathyroidism and 106 (1.

Endoscopic and videofluoroscopic evaluations of swallowing for dysphagia: A systematic review.

Objective: This systematic review was performed to compare the diagnostic accuracy of FEES and VFSS in evaluating swallowing in adults with dysphagia.

Methods: A search for articles published between January 1991 and March 2020 was carried out in the MEDLINE EMBASE, COCHRANE, SciELO, and LILACS electronic databases. Based on the eligibility criteria, six articles were included.

Use of technologies in thyroid surgery: Latin American Thyroid Society Surgical Affairs Committee Expert Opinion. Part 1.

Thyroidectomyis the most frequent endocrine surgical treatment for problems such as goiter, thyroid cancer, and Graves' disease. The global incidence of goiter ranges from 5%-20%, with a notably high frequency in less wealthy countries, and the incidence of thyroid cancer is on the rise due to the greater use of diagnostic imaging. Despite medical options, surgery remains essential.

The complexity of tobacco smoke-induced mutagenesis in head and neck cancer.

Tobacco smoke, alone or combined with alcohol, is the predominant cause of head and neck cancer (HNC). We explore how tobacco exposure contributes to cancer development by mutational signature analysis of 265 whole-genome sequenced HNC samples from eight countries. Six tobacco-associated mutational signatures were detected, including some not previously reported.

Targeted Therapy for the Management of Oral Potentially Malignant Disorders: A Systematic Review.

Objective: This study aimed to integrate the available data published in the literature to identify and elucidate the impact of targeted therapy for oral potentially malignant disorders (OPMDs).

Material And Methods: This systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 statement. An electronic search across five databases with no publication date restriction was conducted in January 2023 and subsequently updated in January 2024.