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Article Abstract
Purpose: To evaluate the different expression of Cdk5 two activators, p35 and p39 throughout rats Vc development.
Methods: The changes of Cdk5 activity, expression of Cdk5 and p39 in the development in spinal trigeminal subnucleus caudalis(Vc) were studied by Western blotting, immunoprecipitation and kinase assay. Statistical analysis was performed using SPSS11.0 software package.
Results: Western blot showed that p39 expression was low at newborn, and highest at the 2-3 week-old rat Vc. In the adult rat Vc, expression declined to the same level as in newborn rat Vc. In contrast, the expression of Cdk5 was constant throughout the development rat Vc. Cdk5 activity in the newborn rat Vc(115.5 Kcpm),which was about 6 times higher than that in normal adult rat Vc(19.0 Kcpm). There was significant difference between each group(P<0.01).
Conclusions: Expression of p35 and p39 is differentially distributed throughout rat Vc. Cdk5/p35 and Cdk5/p39 may play different roles in distinct brain regions during different states of the rat Vc development.
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