Article Synopsis
- The Third International Conference on Mechanisms of Action of Nutraceuticals (ICMAN 3) gathered global researchers to discuss the benefits of dietary supplements in chronic diseases like heart disease, cancer, and neurodegenerative disorders.
- These nutraceuticals are linked to various biological processes, such as enhancing antioxidant defenses, promoting cell survival, and reducing inflammation, which may help protect against age-related diseases.
- The symposium highlighted recent discoveries in functional foods and micronutrients that can promote health and lower the risk of major chronic illnesses.
Video Abstracts
Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The "Third International Conference on Mechanisms of Action of Nutraceuticals" (ICMAN 3) was held to bring investigators from around the world together to find answers and share experience relevant to the role of nutraceuticals in health and disease. Dietary supplements are currently receiving recognition as being beneficial in coronary heart disease, cancer, osteoporosis and other chronic and degenerative diseases such as diabetes, Parkinson's and Alzheimer's diseases. This gave impetus to investigate the mechanisms of action of nutraceuticals and related bioactive compounds in disease pathologies. Many lines of evidence indicate that the mechanistic actions of natural compounds involve a wide array of biological processes, including activation of antioxidant defenses, signal transduction pathways, cell survival-associated gene expression, cell proliferation and differentiation and preservation of mitochondrial integrity. Furthermore, many of these compounds exert anti-inflammatory actions through inhibition of oxidative stress-induced transcription factors (e.g., NF-kappaB, AP-1), cytotoxic cytokines and cyclooxygenase-2. It appears that these properties play a crucial role in the protection against the pathologies of numerous age-related or chronic diseases. This review summarizes the latest research finding in functional foods and micronutrients in the promotion of health and reduction of risk for major chronic diseases as presented in this symposium.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jnutbio.2005.03.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Estimated fracture risk in osteopenic patients with primary hyperparathyroidism.
Endocrine
September 2025
Otorhinolaryngology, Head and Neck Surgery, Candiolo Cancer Institute, FPO-IRCCS Turin, Turin, Italy.
Background: While osteoporosis in primary hyperparathyroidism (PHPT) is widely studied, PHPT patients with osteopenia remain less characterized. This study aimed to evaluate the prevalence, biochemical features, and estimated fracture risk of osteopenic PHPT patients in a real-life cohort.
Methods: We retrospectively analyzed a consecutive series of PHPT patients with available densitometric data at three sites.
Models of care for children and adolescents with type 1 diabetes in low- and middle-income countries: a scoping review.
Cochrane Database Syst Rev
September 2025
Cochrane Evidence Synthesis Unit Germany/UK - Sub-Unit Düsseldorf, Institute of General Practice, Centre for Health and Society, Medical Faculty of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Background: In order to improve the outcomes of children and adolescents with type 1 diabetes mellitus (T1DM), access to and quality of comprehensive acute and chronic care services in low- and middle-income countries (LMIC) must be improved.
Objectives: To identify and summarise the characteristics of models of care for T1DM in children and adolescents in LMIC.
Search Methods: We searched MEDLINE, Scopus, the Cochrane Central Register of Controlled Trials (CENTRAL), and the World Health Organization (WHO) Global Index Medicus from inception to 11 December 2023 without restrictions.
Multidisciplinary team management of caesarean scar ectopic pregnancy progressing to a live birth and caesarean hysterectomy at 34 weeks: A case report.
Case Rep Womens Health
October 2025
The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Progression of a caesarean scar ectopic pregnancy (CSEP) to a live birth is exceptionally rare. Whether the placenta should be removed during a caesarean section for patients with a CSEP complicated by severe placenta accreta spectrum remains unclear. This report presents the case of a 42-year-old multigravida with two prior caesarean sections who presented with CSEP at 6 weeks.
View Article and Find Full Text PDFSurgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study.
Lancet Reg Health West Pac
September 2025
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Background: There is ongoing controversy as to whether surgical intervention to haematoma evacuation benefits patients with acute intracerebral haemorrhage (ICH). This study aimed to evaluate the association of surgical intervention to evacuate the haematoma and 6-month functional outcome in participants of the third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3).
Methods: This was a secondary analysis of INTERACT3, which enrolled adults (age ≥18 years) spontaneous ICH patients within 6 h after onset.
A machine learning based dual-energy CT elemental decomposition method and its physical-biological impacts on carbon ion therapy.
Med Phys
September 2025
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
Background: Dual-energy computed tomography (DECT) enhances material differentiation by leveraging energy-dependent attenuation properties particularly for carbon ion therapy. Accurate estimation of tissue elemental composition via DECT can improve quantification of physical and biological doses.
Objective: This study proposed a novel machine-learning-based DECT (ML-DECT) method to predict the physical density and mass ratios of H, C, N, O, P, and Ca.