Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Genes conferring resistance to one of the macrolide-lincosamide-streptogramin (MLS) antibiotics may confer cross-resistance to others, because they have similar effects on bacterial protein synthesis. In Korea, over 70% of Staphylococcus aureus isolates are methicillin-resistant and erythromycin-resistant methicillin-resistant S. aureus (MRSA) is also prevalent. We investigated the frequency of MLS resistance in erythromycin-resistant S. aureus isolates. A total of 682 isolates of S. aureus were collected in a nationwide antibiotic resistance survey. Susceptibility to erythromycin, clindamycin, and quinupristin/dalfopristin was tested by disk diffusion. In all, 37% of the methicillin-susceptible S. aureus (MSSA) and 97% of the MRSA isolates were resistant to at least one of the MLS antibiotics, whereas all were susceptible to quinupristin/dalfopristin. Out of 518 strains that were resistant to erythromycin, 60 clindamycin-susceptible (30 MSSA, 30 MRSA) and 44 clindamycin-resistant isolates (14 MSSA, 30 MRSA) were selected at random from these strains. Thirteen genes related to MLS resistance were detected in these isolates by PCR. Of the 104 MSSA and MRSA strains tested, 98 harbored one or more erm gene. The most common was erm(A), with erm(C) next. But, msr(A), lnu(A), and mef(A) were rare and no resistance to streptogramin A was encountered.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1089/mdr.2004.10.248 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterization, photocatalysis, antimicrobial and antioxidant activities of manganese oxide nanoparticles green synthesis using seed extract.
Int J Phytoremediation
September 2025
Innovative Food Technologies Development Application and Research Center, Gölköy Campus Bolu, Bioenvironment and Green Synthesis Research Group, Bolu Abant İzzet Baysal University, Bolu, Türkiye.
This study presents an eco-friendly approach for the green synthesis of manganese oxide nanoparticles (MnONPs) using () (einkorn wheat) seed extract as a reducing and stabilizing agent. The synthesized MnONPs were characterized by UV-Vis, XRD, FTIR, SEM-EDX, BET, and zeta potential analyses, which confirmed their crystalline nature, spherical morphology, and mesoporous structure with a surface area of 41.50 m/g.
View Article and Find Full Text PDFInvestigation into Antibiotic Resistance Profiles of Among Chronic Rhinosinusitis Patients and Multifaceted Analysis of Factors Influencing Methicillin-Resistant Infection.
Infect Drug Resist
August 2025
Department of Otolaryngology, Affiliated People's Hospital of Shandong First Medical University, Shandong, Jinan, People's Republic of China.
Objective: This study aimed to comprehensively investigate the antibiotic resistance characteristics of in chronic rhinosinusitis (CRS) patients and to identify key determinants influencing the development of methicillin-resistant Staphylococcus aureus (MRSA) infections.
Methods: A retrospective analysis was conducted on 180 CRS patients admitted to our hospital between February 2022 and July 2024. Nasal secretion samples were collected upon admission for strain isolation, and antibiotic susceptibility testing was performed using an automated microbiology system.
In Vivo Emergence of Podovirus Resistance via Mutation During Phage-Antibiotic Treatment of Experimental MSSA Endocarditis.
Viruses
July 2025
Laboratory of Bacteriophages and Phage Therapy, Center for Research and Innovation in Clinical Pharmaceutical Sciences (CRISP), Lausanne University Hospital (CHUV), CH-1011 Lausanne, Switzerland.
Phage therapy shows promise as an adjunct to antibiotics for treating Staphylococcus aureus infections. We previously reported a combined flucloxacillin/two-phage cocktail treatment selected for resistance to podovirus phage 66 in a rodent model of methicillin-susceptible (MSSA) endocarditis. Here we show that resistant clones harbor mutations in , which encodes a glycosyltransferase essential for β-GlcNAcylation of wall teichoic acid (WTA).
View Article and Find Full Text PDFAntibiotic-Loaded Bioglass 45S5 for the Treatment and Prevention of Infections in Orthopaedic Surgery: A Novel Strategy Against Antimicrobial Resistance.
Pathogens
August 2025
School of Pharmacy and Pharmaceutical Sciences, Ulster University, Cr Road, Coleraine BT52 1SA, UK.
This study explores the potential of biodegradable Bioglass 45S5 formulations as a dual-function approach for preventing and treating infections in orthopaedic surgery while addressing the growing concern of antimicrobial resistance (AMR). The research focuses on the development and characterisation of antibiotic-loaded BG45S5 formulations, assessing parameters such as drug loading efficiency, release kinetics, antimicrobial efficacy, and dissolution behaviour. Key findings indicate that the F2l-BG45S5-T-T-1.
View Article and Find Full Text PDFComprehensive Molecular and Epidemiological Characterization of Isolated from Bovine Mastitis in Water Buffalo of the Peshawar Division, Khyber Pakhtunkhwa, Pakistan.
Pathogens
July 2025
Centre for Antimicrobial Resistance, Alberta Health Services/Alberta Precision Laboratories/University of Calgary, Calgary, AB T2N 4N1, Canada.
Water buffalo () are a primary source of milk in Pakistan, where bovine mastitis is a significant health issue among cattle, leading to substantial economic losses. is a predominant pathogen associated with mastitis; however, a detailed molecular characterization of the strains in the country remains limited. We previously characterized mastitis strains from the Hazara division of Khyber Pakhtunkhwa, Pakistan.
View Article and Find Full Text PDF