98%
921
2 minutes
20
We describe methods to identify high and low responders in a whole-blood assay of lipopolysaccharide-stimulated cytokine responses. Two multivariate measures of the cytokine responses both captured high and low responses for each of the four individual cytokines that were assayed.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC427430 | PMC |
http://dx.doi.org/10.1128/IAI.72.7.4282-4285.2004 | DOI Listing |
Mol Syst Biol
September 2025
Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.
The complex interplay between circulating metabolites and immune responses, which is pivotal to disease pathophysiology, remains poorly understood and understudied in systematic research. Here, we performed a comprehensive analysis of the immune response and circulating metabolome in two Western European cohorts (534 and 324 healthy individuals) and one from sub-Saharan Africa (323 healthy donors). At the metabolic level, our analysis revealed sex-specific differences in the correlation between phosphatidylcholine and cytokine responses following ex vivo stimulation.
View Article and Find Full Text PDFNature
September 2025
Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Cancer-associated muscle wasting is associated with poor clinical outcomes, but its underlying biology is largely uncharted in humans. Unbiased analysis of the RNAome (coding and non-coding RNAs) with unsupervised clustering using integrative non-negative matrix factorization provides a means of identifying distinct molecular subtypes and was applied here to muscle of patients with colorectal or pancreatic cancer. Rectus abdominis biopsies from 84 patients were profiled using high-throughput next-generation sequencing.
View Article and Find Full Text PDFTranspl Immunol
September 2025
Department of Endocrine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Background: Diabetic nephropathy (DN) represents approximately 50 % of all chronic kidney disease cases. Given the established involvement of USP22 in DN progression, this study investigated its underlying regulatory mechanisms.
Methods: Mouse podocytes were treated with high glucose (HG), and a diabetic mouse model was established.
J Ethnopharmacol
September 2025
Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address:
Ethnopharmacological Relevance: Acute lung injury (ALI) is a severe health issue characterized by high morbidity and mortality, driven by excessive inflammatory responses. The traditional Chinese medicine Huashi Baidu Granules (HBG) demonstrated clinical efficacy in treating severe ALI, yet its mechanisms remain unclear.
Aim Of The Study: This research aimed to examine the efficacy and underlying mechanisms of HBG in a lipopolysaccharide (LPS)-induced ALI model, identify core herbal constituents, active compounds, and therapeutic targets, providing a foundation for optimizing HBG-based treatments.
Gene
September 2025
Institute of Physiology, Medical School, University of Pécs H-7624 Pécs, Hungary. Electronic address:
In this edition of Gene's "Editor's Corner" we summarize the complex interactions of different molecular mechanisms behind the pathogenesis of neonatal hypoxic-ischemic encephalopathy (HIE). The topic is relevant, as the therapeutic options for HIE are limited, it is important to have as much knowledge as possible about the molecular processes underlying the disease. In the recent issue of Gene (Gene 952, 2025, 149363), Wang et al.
View Article and Find Full Text PDF