Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To investigate the relation between changes in serum vascular endothelial growth factor (VEGF) level after transcatheter arterial chemoembolization (TACE) and hepatocellular carcinoma (HCC) progression, especially in relation to metastasis.
Methods: Serum VEGF expression level, measured by quatitative sandwich enzyme-linked immunosorbent assay (ELISA, R&D system), was measured before, 3 days and 4 weeks after TACE in 30 patients with HCC. The development of metastasis was evaluated at the end of the third month after TACE.
Results: 1. The serum VEGF level in 30 patients was 154.47 +/- 90.17 pg/ml, 2. Post-TACE total serum VEGF level increased as compared with their basal level in 30 patients (P < 0.05) and serum VEGF level had a tendency to increase in patients with heterogeneous uptake of iodized oil and portal vein thrombosis. During the follow-up of 1 - 2 years, metastatic foci were found in 74% (20) patients with SVEGF increase, while none of the patients showing SVEGF decrease developed metastasis.
Conclusion: Serum VEGF expression increase is associated with the development of metastasis in hepatocellular carcinoma after TACE.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Cytokine biomarkers and their relationship to symptoms and quality of life in people with HIV-associated Kaposi sarcoma.
HIV Med
September 2025
Department of Dermatology, University of Kwa-Zulu Natal, Durban, South Africa.
Introduction: Quality of life (QOL) is an essential component of care in people with HIV-associated Kaposi sarcoma (HIV-KS). Kaposi sarcoma herpes virus (KSHV) promotes cytokine expression and a dysfunctional inflammatory environment, contributing to KS pathogenesis and progression. However, disease-related inflammatory factors influencing QOL and symptoms remain underexplored.
View Article and Find Full Text PDFExtracts and pimaradienoic acid from Eleutherococcus trifoliatus L. S. Y. Hu for the treatment of Rheumatoid Arthritis by modulating NF-κB signaling pathway.
J Ethnopharmacol
September 2025
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, PR China. Electronic address:
Ethnopharmacological Relevance: The use of Eleutherococcus trifoliatus L. S. Y.
View Article and Find Full Text PDFReduced levels of vascular endothelial growth factor were associated with psychopathology in youth with first-episode schizophrenia.
Schizophr Res
September 2025
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:
Background: Youth is a critical period for brain development, yet first-episode schizophrenia (FES) during this stage remains understudied, particularly concerning the role of vascular endothelial growth factor (VEGF) in schizophrenia-related psychopathology and cognitive dysfunction.
Methods: This study enrolled 32 youth (ages 12-24) with FES and 35 age-/sex-matched healthy controls. Serum VEGF levels were measured using enzyme-linked immunosorbent assay.
Repurposing rupatadine to attenuate ovarian ischemia reperfusion in rats through modulation of PAF/NF-κB/TNF-α/IL-1β; HIF-1α/VEGF/Caspase 3 signaling pathways.
Naunyn Schmiedebergs Arch Pharmacol
September 2025
Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61519, Egypt.
The aim of the current study is to identify the possible protective effect of rupatadine (RUP) on ovarian ischemia reperfusion (OIR) in rats. RUP was administered in the presence and absence of OIR. Thirty-two adult Wistar albino female rats were randomly arranged into four groups: Sham, RUP (6 mg/kg/day) for 14 days, OIR and OIR + RUP groups.
View Article and Find Full Text PDF[Immune function regulation and tumor-suppressive effects of Shenqi Erpi Granules on S_(180) tumor-bearing mice].
Zhongguo Zhong Yao Za Zhi
July 2025
School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
This study aims to establish the S_(180) tumor-bearing mice model, and to investigate the influence of Shenqi Erpi Granules(SQEPG) on immune function, as well as the drug's tumor-suppressive effect and mechanism. SPF grade KM mice(half male and half female) were randomly divided into 6 groups: a control group, a model group, a cyclophosphamide group(50 mg·kg~(-1)), as well as SQEPG groups in low-, medium-, and high-dose(5.25, 10.
View Article and Find Full Text PDF