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http://dx.doi.org/10.3748/wjg.v6.i5.742 | DOI Listing |
Eur J Case Rep Intern Med
August 2025
Dermatology Department, Ain Shams University Hospital, Cairo, Egypt.
Background: Dissecting cellulitis of the scalp (DCS) is a rare, chronic neutrophilic dermatosis that is often refractory to conventional therapies.
Case Report: We present a 29-year-old male with treatment-resistant DCS who achieved rapid and sustained remission following off-label use of tofacitinib, a Janus kinase (JAK) inhibitor. Previous therapies, including antibiotics, corticosteroids, and isotretinoin, had failed.
Int J Nanomedicine
September 2025
The First Hospital of Hunan University of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, People's Republic of China.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease, the incidence of which continues to rise globally, and existing therapeutic options are limited by low drug bioavailability and systemic side effects. In this study, we systematically investigated the challenges of the special gastrointestinal environment of UC patients for oral drug delivery, such as extreme pH, degradation by digestive enzymes, metabolism of intestinal flora and obstruction of the intestinal mucosal barrier, and summarized the potential of plant-derived Exosome-like Nanovesicles (PELNs) as a novel delivery system. PELNs are produced by plant cells and mainly consist of proteins, RNA, lipids and plant active molecules.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Background: Diabetic foot ulcers (DFU) are a prevalent complication of diabetes, leading to significant morbidity, mortality, and amputation rates. Chronic non-healing DFU often result from peripheral neuropathy, microvascular issues, and infection, with poor blood and oxygen supply being critical factors in delayed healing. The development of new treatments to promote blood supply and accelerate ulcer healing is a significant area of research for DFU management.
View Article and Find Full Text PDFCan Vet J
September 2025
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn Alabama, USA (Schwartz, Waters, Cole, Forehand, Prim, Rush, Stockler); Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn Alabama, USA (Neto).
A 1-year-old intact Nigerian dwarf nulliparous doe was presented to the Auburn University College of Veterinary Medicine, Large Animal Teaching Hospital in March 2024 for evaluation of recurrent perivulvar masses of 3 mo duration. Transcutaneous ultrasonographic examination of the labia and ventrolateral peri-vulvar area was carried out. This examination revealed a horizontally oriented, bilobed mass on the dorsal left labia majora, and a separate mass located directly below the ventral vulvar commissure.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Nursing, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Inflammatory bowel disease (IBD) is a chronic condition characterized by the need for highly individualized treatment plans, requiring patients to make numerous complex medical decisions. Shared decision-making (SDM) has proven effective in improving treatment outcomes, patient satisfaction, and adherence in IBD management; however, its clinical implementation remains challenging. In China, formal SDM nurse roles have not yet been established.
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