Gut microbiota as a metabolic mediator to prevent or attenuate MASLD.

As a metabolic disorder, metabolic dysfunction-associated steatotic liver disease (MASLD) may be prevented through strategic adjustments of the gut microbiome, which could be reshaped by dietary intakes, and in turn, improve the host's health via various metabolic activities. The human gut harbors a diverse array of microorganisms that play a crucial role in host health. Through the gut-liver axis, bile acid metabolism, tryptophan metabolism, and short-chain fatty acid metabolism of gut microbiota significantly influence hepatic metabolic processes.

Study on the effect of NH on the solubility of KCl and NHCl: a microscopic view.

KCl is an important fertilizer that is used worldwide. NHCl solution is an eluent for potassium extraction from seawater using zeolite. The product solution obtained from the zeolite method for potassium extraction from seawater usually contains both potassium chloride and ammonium chloride.

Comparative assessment of silver nanoparticle and silver nitrate toxicities in Mytilus galloprovincialis.

Silver nanoparticles (AgNPs) and Ag ions are both detected in aquatic environments, posing potential risks to marine ecosystems. Mytilus galloprovincialis is an effective model for monitoring marine environments. In this study, AgNPs were synthesized using a chemical approach, and to distinguish the toxicological effects of AgNPs and AgNO in M.

Hyaluronic acid-mediated targeted nano-modulators for activation of pyroptosis for cancer therapy through multichannel regulation of Ca overload.

Calcium-based nanomaterials-mediated Ca overload-induced pyroptosis and its application in tumor therapy have received considerable attention. However, the calcium buffering capacity of tumor cells can maintain mitochondrial calcium homeostasis, so it is important to effectively disrupt this homeostasis to activate pyroptosis. Here, a nano-modulator CUR@CaCO-PArg@HA (CCAH) was developed to regulate calcium overload in multiple channels and activate pyroptosis.

Toxic effects of ZnO NPs on immune response and tissue pathology in Mytilus galloprovincialis.

Nano-zinc oxide (ZnO NPs), as widely used nanomaterials, are inevitably released into aquatic environments, posing potential threats to aquatic organisms. Mytilus galloprovincialis is a bivalve species sensitive to changes in marine ecological environments, but there has been limited research on its toxicity response to ZnO NPs. Therefore, we selected M.

ABT‑737 increases cisplatin sensitivity through the ROS‑ASK1‑JNK MAPK signaling axis in human ovarian cancer cisplatin‑resistant A2780/DDP cells.

Ovarian cancer is a gynecological malignant tumor with the highest mortality rate, and chemotherapy resistance seriously affects patient therapeutic outcomes. It has been shown that the high expression of anti‑apoptotic proteins Bcl‑2 and Bcl‑xL is closely related to ovarian cancer chemotherapy resistance. Therefore, reducing Bcl‑2 and Bcl‑xL expression levels may be essential for reversing drug resistance in ovarian cancer.

A multifunctional cascade enzyme system for enhanced starvation/chemodynamic combination therapy against hypoxic tumors.

Starvation therapy has shown promise as a cancer treatment, but its efficacy is often limited when used alone. In this work, a multifunctional nanoscale cascade enzyme system, named CaCO@MnO-NH@GOx@PVP (CMGP), was fabricated for enhanced starvation/chemodynamic combination cancer therapy. CMGP is composed of CaCO nanoparticles wrapped in a MnO shell, with glucose oxidase (GOx) adsorbed and modified with polyvinylpyrrolidone (PVP).

The acute neurotoxicity of inorganic mercury in Mactra chinensis philippi.

Inorganic mercury (IHg) is hazardous to marine organisms especially resulting in neurotoxicity, bivalves are sensitive to pollutants as "ocean sentinel", but data on the neurotoxicity of IHg in bivalves are sparse. So we chosed M. chinensis philippi with typical neural structures in bivalves to investigate the neurotoxicity of IHg, which could be helpful to understand the specificity of neural regulation and the response characteristics of bivalves.

Heterogeneous responses of wetland vegetation to climate change in the Amur River basin characterized by normalized difference vegetation index from 1982 to 2020.

Climate change affects wetland vegetation dramatically in mid- and high- latitudes, especially in the Amur River basin (ARB), straddling three countries and distributing abundance wetlands. In this study, spatiotemporal changes in average normalized difference vegetation index (NDVI) of wetland during the annual growing season were examined in the ARB from 1982 to 2020, and the responses of wetland vegetation to climatic change (temperature and precipitation) in different countries, geographic gradients, and time periods were analyzed by correlation analysis. The NDVI of wetland in the ARB increased significantly ( < 0.

Extracellular vesicles mediated proinflammatory macrophage phenotype induced by radiotherapy in cervical cancer.

Background: Radiotherapy is a highly effective treatment for cervical cancer. Recent studies focused on the radiotherapy induced anti-tumor immunity. Whether tumor-derived extracellular vesicles (EVs) play roles in radiotherapy induced tumor associated macrophage (TAM) polarization remains unclear.