mGluR5 regulates inflammatory pain and pain aversion of CFA mice by mediating ERK/PI3K signaling pathway.

To investigate whether metabotropic glutamate receptor 5 (mGluR5) in the basolateral amygdala (BLA) regulates inflammatory pain and pain aversion by mediating ERK/PI3K signaling pathway in mice. Two experimental routes were designed. In route 1, 18 male C57BL/6 mice were divided into control, IFA, and CFA groups.

A Redox Mediator Containing Reversible Dynamic Boron-Oxygen Bonds to Construct an Adaptive SEI Layer for Advanced Li-O Batteries.

Lithium-oxygen (Li-O) batteries have high theoretical energy density, but the discharge product LiO of Li-O batteries is difficult to decompose, resulting in the undesirably high charging potential. The use of soluble redox mediators (RMs) can usually reduce the high charging potential of Li-O batteries, but the RM on the cathode side can diffuse to the Li metal anode and react with it, leading to continuous loss of the RM and causing damage to the fragile Li anode interface. So, it is necessary to develop a bifunctional redox mediator (BRM) that can simultaneously reduce the charging potential and protect the Li anode.

Electroacupuncture improves cognitive function in high-fat diet/streptozocin-induced type 2 diabetic mice by inhibiting autophagy-related ferroptosis.

At present, there lacks a definitive pharmaceutical intervention or therapeutic approach for diabetes-associated cognitive impairment. Herein, we delved into the impact of electroacupuncture on cognitive function in high-fat diet/streptozocin (HFD/STZ)-induced type 2 diabetes mellitus (T2DM) mice and underlying mechanisms. Hippocampal insulin resistance was determined by western blot analysis.

Interventions to Improve Adherence to Oral Pre-exposure Prophylaxis: A Systematic Review and Network Meta-analysis.

For people at risk of HIV infection, pre-exposure prophylaxis (PrEP) can reduce the risk of infection in anticipation of exposure to HIV. The effectiveness of PrEP relies upon a user's adherence to their PrEP regimen. We sought to assess the effect of PrEP adherence interventions compared to usual care or another intervention for people at risk of HIV.

Des-Arg(9) bradykinin as a causal metabolite for autism spectrum disorder.

Background: Early diagnosis and therapeutic interventions can greatly enhance the developmental trajectory of children with autism spectrum disorder (ASD). However, the etiology of ASD is not completely understood. The presence of confounding factors from environment and genetics has increased the difficulty of the identification of diagnostic biomarkers for ASD.

Growing Like a Tree: Finding Trunks From Graph Skeleton Trees.

The message-passing paradigm has served as the foundation of graph neural networks (GNNs) for years, making them achieve great success in a wide range of applications. Despite its elegance, this paradigm presents several unexpected challenges for graph-level tasks, such as the long-range problem, information bottleneck, over-squashing phenomenon, and limited expressivity. In this study, we aim to overcome these major challenges and break the conventional "node- and edge-centric" mindset in graph-level tasks.

Gold-Nanorod-Assisted Live Cell Nuclear Imaging Based on Near-Infrared II Dark-Field Microscopy.

Dark-field microscopy offers several advantages, including high image contrast, minimal cell damage, and the absence of photobleaching of nanoprobes, which make it highly advantageous for cell imaging. The NIR-II window has emerged as a prominent research focus in optical imaging in recent years, with its low autofluorescence background in biological samples and high imaging SBR. In this study, we initially compared dark-field imaging results of colorectal cancer cells in both visible and NIR-II wavelengths, confirming the superior performance of NIR-II imaging.

A New Imidazole Derivative for Corrosion Inhibition of Q235 Carbon Steel in an Acid Environment.

Q235 carbon steel is a commonly used engineering material, but its application in marine environments is limited by its susceptibility to corrosion, especially localized corrosion that can lead to material perforation. Effective inhibitors are crucial to addressing this issue, particularly in acidic environments where localized areas become increasingly acidic. This study reports the synthesis of a new imidazole derivative corrosion inhibitor and evaluates its effectiveness in corrosion inhibition performance using potentiodynamic polarization curve and electrochemical impedance spectroscopy techniques.

Graph-Enhanced Emotion Neural Decoding.

Brain signal-based emotion recognition has recently attracted considerable attention since it has powerful potential to be applied in human-computer interaction. To realize the emotional interaction of intelligent systems with humans, researchers have made efforts to decode human emotions from brain imaging data. The majority of current efforts use emotion similarities (e.

FgMet3 and FgMet14 related to cysteine and methionine biosynthesis regulate vegetative growth, sexual reproduction, pathogenicity, and sensitivity to fungicides in .

is a destructive filamentous fungus, which widely exists in wheat and other cereal crops. Cysteine and Methionine are unique sulfur-containing amino acids that play an essential role in protein synthesis and cell life, but their functions and regulation in remain largely unknown. Here we identified two proteins, FgMet3 and FgMet14 in , which are related to the synthesis of cysteine and methionine.

Interpretation of a Quantitative Diagnosis Model of Traditional Chinese Medicine Syndromes Based on Computer Adaptive Testing.

Objectives: The aim of this study is to interpret a quantitative diagnosis model of traditional Chinese medicine (TCM) syndromes based on computer adaptive testing (CAT), from the perspective of both patients and clinicians.

Methods: In this cross-sectional study, patients with postprandial distress syndrome completed the CAT model of TCM syndromes and the Chinese version of the Quality of Life Questionnaire for Functional Digestive Disorders (Chin-FDDQL); the clinicians' diagnosis was concurrently recorded. The patients completed this questionnaire again after 14 ± 2 days.

Assessment of NO population exposure from 2005 to 2020 in China.

Nitrogen dioxide (NO) is a major air pollutant with serious environmental and human health impacts. A random forest model was developed to estimate ground-level NO concentrations in China at a monthly time scale based on ground-level observed NO concentrations, tropospheric NO column concentration data from the Ozone Monitoring Instrument (OMI), and meteorological covariates (the MAE, RMSE, and R of the model were 4.16 µg/m, 5.

Comprehensive analysis of an immune infiltrate-related competitive endogenous RNA network reveals potential prognostic biomarkers for non-small cell lung cancer.

Globally, non-small cell lung cancer (NSCLC) is the most common malignancy and its prognosis remains poor because of the lack of reliable early diagnostic biomarkers. The competitive endogenous RNA (ceRNA) network plays an important role in the tumorigenesis and prognosis of NSCLC. Tumor immune microenvironment (TIME) is valuable for predicting the response to immunotherapy and determining the prognosis of NSCLC patients.

Quantifying Liver-Stomach Disharmony Pattern of Functional Dyspepsia Using Multidimensional Analysis Methods.

Purpose: This study aims to develop and validate a quantitative model for measuring severity of a typical traditional Chinese medicine (TCM) pattern for functional dyspepsia (FD) using multidimensional analysis methods including confirmatory factor analysis (CFA) and multidimensional item response theory (MIRT).

Methods: A scale and theoretical models were constructed according to the definition of pathogenesis about "liver-stomach disharmony" patterns of FD. With data collected from 502 patients in a cross-section study, the theoretical model was validated with CFA, and the related validity and reliability were evaluated in Amos 21.

A Methodological and Reporting Quality Assessment of Systematic Reviews/Meta-Analyses about Chinese Medical Treatment for Gastroesophageal Reflux Disease.

Objective: To access the methodological and reporting quality of systematic reviews (SRs)/meta-analyses (MAs) about Chinese medical treatment for gastroesophageal reflux disease (GERD).

Methods: The PubMed, Wanfang Data, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), Chinese Biomedical (CBM), Web of Science, and Cochrane Library databases were searched from inception to June 2020. Two researchers independently screened the literature considering the eligibility criteria.

Reviews and Thoughts on the Relevance between Qualitative Chinese Medicinal Properties and Quantitative Material Components.

Objective: Chinese Medicinal Properties (CMP) play a vital role in theoretical research and clinical practice. However, the traditional CMP system is subjective, qualitative, fixed, inconsistent, and obscured. Nowadays, quantifying CMP research achieved a notable progress.

Quantifying Liver Stagnation Spleen Deficiency Pattern for Diarrhea Predominate Irritable Bowel Syndromes Using Multidimensional Analysis Methods.

Objective: This study aims to offer a new approach for quantifying severity of traditional Chinese medicine pattern with multidimensional analysis methods.

Methods: A scale and theoretical models were constructed based on the definition of liver stagnation spleen deficiency pattern. Clinical data of 344 IBS-D patients from a cross-sectional study was used for feature validation of the model.

Laparoscopic Partial Nephrectomy for T1 Renal Cell Carcinoma: Comparison of Two Resection Techniques in a Multi-institutional Propensity Score-Matching Analysis.

Background: Enucleoresection is defined as presence of a minimal paratumor parenchyma that allows for clear visualization of the tumor's contours during partial nephrectomy (PN). Because there is variability in published reports regarding resection techniques during PN before the surface-intermediate-base (SIB) margin score reporting system, the association between postoperative outcomes and resection techniques are rarely reported. This study was designed to compare the perioperative, oncologic, and functional outcomes between laparoscopic enucleoresection (LER) (SIB score 1 + 1 + 1 = 3) and traditional laparoscopic partial nephrectomy (TLPN) (SIB score 1 + 2 + 2 = 5).