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Article Abstract
To investigate whether metabotropic glutamate receptor 5 (mGluR5) in the basolateral amygdala (BLA) regulates inflammatory pain and pain aversion by mediating ERK/PI3K signaling pathway in mice. Two experimental routes were designed. In route 1, 18 male C57BL/6 mice were divided into control, IFA, and CFA groups. In route 2, 18 mice received stereotaxic BLA injections of ACSF, the mGluR5 agonist DHPG, or antagonist MTEP on day 8 following CFA administration. Pain behaviors and aversive emotions were assessed over 14 days. BLA tissues were collected on day 15 for immunofluorescence staining and Western blot analyses of mGluR5, PI3K, p-PI3K, and ERK1/2 expression. The expression levels of p-PI3K, mGluR5 and ERK1/2 in the BLA of CFA mice were significantly increased, suggesting that their activation was associated with inflammatory pain. DHPG increased the expression of p-PI3K and mGluR5 and ERK1/2 in the CFA mouse brain BLA, while MTEP had the opposite effect. Our results show that mGluR5 regulates inflammatory pain and pain aversion of CFA mice by mediating the ERK/PI3K signaling pathway.
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| http://dx.doi.org/10.1016/j.neulet.2025.138281 | DOI Listing |
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