Mito-fission gene prognostic model for colorectal cancer.

Background: Dysregulated cellular metabolism is one of the major causes of colorectal cancer (CRC), including mitochondrial fission. Therefore, this study focuses on the specific regulatory mechanisms of mitochondrial dysfunction on CRC, which will provide theoretical guidance for CRC in the future.

Methods: The Cancer Genome Atlas (TCGA)-CRC dataset, GSE103479 dataset and 40 mitochondrial fission-related genes (MFRGs) were downloaded in this study.

Extraction and Tissue Clearing Preparation of Mouse Brain-Spinal Cord Samples.

Neuroscience research focused on the central nervous system necessitates a thorough understanding of various factors, including cell distribution, neuronal connectivity, and molecular dynamics. Traditional methodologies for investigating the entire brain and spinal cord often involve isolating, sectioning, and scanning tissue slices, followed by the labor-intensive process of three-dimensional image reconstruction. This conventional approach can be both time-consuming and cumbersome.

The overwintering situation and influencing factors of Fulmekiola serrata in Yunnan sugarcane planting areas of China.

Sugarcane thrips, Fulmekiola serrata (Kobus), is a common leaf pest of sugarcane. To clarify the occurrence and overwintering of F. serrata in Yunnan sugarcane planting areas of China in winter and the influencing factors, five surveys on the occurrence and overwintering of thrips in sugarcane were carried out at three bases of the Sugarcane Research Institute, Yunnan Academy of Agricultural Sciences, in January and February 2023, targeting five varieties and two sugarcane growth periods.

New application of intestinal obstruction catheter in enterocutaneous fistula: A case report.

Background: Enterocutaneous fistula (ECF) is an abnormal connection between the gastrointestinal tract and the skin. ECF can lead to massive body fluid loss, hypercatabolism, and malnutrition. Therefore, nutritional support plays a crucial role in managing ECFs and promoting the healing of fistulas.

A morphological traits dataset of Heteroptera sampled in biodiversity priority areas of Southwest China.

Functional traits reveal the adaptive strategies of species to their environment, and are relevant to the formation of communities, the function of ecosystems, and the mechanisms underlying biodiversity. However, trait databases have not been established for most biological taxa, especially for insects, which encompass a vast number of species. This study measured the morphological traits of 307 species of Heteroptera insects collected in 2019 from the "Xishuangbanna Priority Conservation Area" in Southwest China using sweep netting and light trapping methods.

Evolution of Naturally Dried MXene-Based Composite Aerogels with Flash Joule Annealing for Large-Scale Production of Highly Sensitive Customized Sensors.

MXene aerogels, known for good electrical properties, offer immense potential for the development of high-sensitivity pressure sensors. However, the intrinsic challenges stemming from the poor self-assembly capability and high hydrophilicity of MXene impede the natural drying process of MXene-based hydrogels, thereby constraining their application on a large scale in sensor technology. Herein, a graphene-assisted approach aimed at modulating the hydrophobicity and enhancing framework strength of MXene through a well-designed prefreezing technique incorporating 3D spherical macroporous structures is proposed.

Conductance Quantization in 2D Semi-Metallic Transition Metal Dichalcogenides.

Conductance quantization of 2D materials is significant for understanding the charge transport at the atomic scale, which provides a platform to manipulate the quantum states, showing promising applications for nanoelectronics and memristors. However, the conventional methods for investigating conductance quantization are only applicable to materials consisting of one element, such as metal and graphene. The experimental observation of conductance quantization in transition metal dichalcogenides (TMDCs) with complex compositions and structures remains a challenge.

Postoperative Sleep Quality of Insomnia Patients After TIVA Anesthesia: A Prospective Study.

Purpose: The purpose of this study is to observe the postoperative sleep quality of insomnia patients undergoing laparoscopic gynecologic oncology surgery after total intravenous anesthesia.

Design: Prospective study.

Methods: We conducted a prospective, observational study in our hospital.

GlideScope versus C-MAC D-blade videolaryngoscope for double-lumen tube intubation in patients with anticipated difficult airways: A multi-center, prospective, randomized, controlled trial.

Study Objective: Videolaryngoscopes are widely used to visualize difficult airways. Our aim was to compare the GlideScope and C-MAC D-blade videolaryngoscopes for double-lumen tube (DLT) intubation in patients with difficult airways.

Design: A multi-center, prospective, randomized controlled trial.

Intergenic CircRNA Inhibits Colorectal Cancer Progression by Modulating Biogenesis in a KSRP-Dependent Manner.

Circular RNAs (circRNAs) are covalently closed RNA structures that play multiple roles in tumorigenesis and progression. Compared with exon‒intron circRNAs, the biological functions and implications of intergenic circRNAs in human cancer are still poorly understood. Here, we performed circRNA microarray analysis and identified an intergenic circRNA, , that was significantly downregulated in patients with colorectal cancer (CRC).

Single-Atom Control of Single-Molecule van der Waals Junctions with Semimetallic Transition Metal Dichalcogenide Electrodes.

Electrodes play an essential role in controlling electrode-molecule coupling. However, conventional metal electrodes require linkers to anchor the molecule. Van der Waals interaction offers a versatile strategy to connect the electrode and molecule without anchor groups.

ATP13A2 activates the pentose phosphate pathway to promote colorectal cancer growth though TFEB-PGD axis.

Background: The pentose phosphate pathway (PPP) is an important mechanism by which tumour cells resist stressful environments and maintain malignant proliferation. However, the mechanism by which the PPP regulates these processes in colorectal cancer (CRC) remains elusive.

Methods: Closely related PPP genes were obtained from the TCGA and GEO databases.

TIGD1 Function as a Potential Cuproptosis Regulator Following a Novel Cuproptosis-Related Gene Risk Signature in Colorectal Cancer.

Cuproptosis is a new form of copper-dependent programmed cell death commonly occurring within the body. There is emerging evidence indicating that cuproptosis has a significant regulatory function in the onset and progression of cancer. However, it is still unclear how cuproptosis regulates cancer and whether other genes are involved in the regulation.

Chiroptical Nanocellulose Bio-Labels for Independent Multi-Channel Optical Encryption.

Advanced multiplexing optical labels with multiple information channels provide a powerful strategy for large-capacity and high-security information encryption. However, current optical labels face challenges of difficulty to realize independent multi-channel encryption, cumbersome design, and environmental pollution. Herein, multiplexing chiroptical bio-labels integrating with multiple optical elements, including structural color, photoluminescence (PL), circular polarized light activity, humidity-responsible color, and micro/nano physical patterns, are constructed in complex design based on host-guest self-assembly of cellulose nanocrystals and bio-gold nanoclusters.

Bioinspired Stabilization of Amorphous Calcium Carbonate by Carboxylated Nanocellulose Enables Mechanically Robust, Healable, and Sensing Biocomposites.

Nature builds numerous structurally complex composites with fascinating mechanical robustness and functionalities by harnessing biopolymers and amorphous calcium carbonate (ACC). The key to successfully mimicking these natural designs is efficiently stabilizing ACC, but developing highly efficient, biodegradable, biocompatible, and sustainable stabilizing agents remains a grand challenge since anhydrous ACC is inherently unstable toward crystallization in the wet state. Inspired by the stabilized ACC in crustacean cuticles, we report the efficient stabilization ability of the most abundant biopolymer-cellulose nanofibrils (CNFs) for ACC.

Data of ant community compositions and functional traits responding to land-use change at the local scale.

: Off-reserve conservation is a major contributor to China biodiversity conservation efforts, biodiversity conservation being achieved within afforestation and low-intensity agriculture in fragmented landscapes. Functional trait is more strongly related to ecological processes than taxonomic diversity and reflects ecosystem functioning and species responses to environmental changes. In this study, we selected five habitats that differ in degree of disturbance to explore the effects of land use on ant community compositions, traits distributions and functional diversity change.

Protects Acute Myeloid Leukemia Cells from Ferroptotic Cell Death by Upregulating SCD.

Circular RNAs (circRNAs) have been shown to be closely linked to the tumorigenesis and treatment response of hematological malignancies. However, the biological functions and clinical implications of circRNAs in acute myeloid leukemia (AML) remain largely unknown. CircRNA microarray datasets were analyzed to screen differentially expressed circRNAs in AML patients.

LINC01615 maintains cell survival in adaptation to nutrient starvation through the pentose phosphate pathway and modulates chemosensitivity in colorectal cancer.

Numerous mechanisms involved in promoting cancer cell survival under nutrient starvation have been described. Long noncoding RNAs (lncRNAs) have emerged as critical players in colorectal cancer (CRC) progression, but the role of lncRNAs in the progression of CRC under nutrient starvation has not been well clarified. Here, we identified a lncRNA, LINC01615, that was significantly upregulated in response to serum starvation.

GMEB2 Promotes the Growth of Colorectal Cancer by Activating ADRM1 Transcription and NF-κB Signalling and Is Positively Regulated by the mA Reader YTHDF1.

Transcription factors are frequently aberrantly reactivated in various cancers, including colorectal cancer (CRC). However, as a transcription factor, the role of GMEB2 in cancer is still unclear, and further studies are needed. Here, we aimed to identify the function and mechanism of GMEB2 in regulating the malignant progression of CRC.

Identification and Validation of the lncRNA MYOSLID as a Regulating Factor of Necroptosis and Immune Cell Infiltration in Colorectal Cancer following Necroptosis-Related LncRNA Model Establishment.

Unlabelled: Necroptosis is a newly defined form of programmed cell death that plays an important role in cancers. However, necroptosis-related lncRNAs (NRLs) involved in colorectal cancer (CRC) have not yet been thoroughly studied.

Methods: In this study, a 4-NRL model was developed based on the least absolute shrinkage and selection operator (LASSO) algorithm.

COL5A1 Promotes the Progression of Gastric Cancer by Acting as a ceRNA of miR-137-3p to Upregulate FSTL1 Expression.

MicroRNAs (miRNAs) and their target genes have been shown to play an important role in gastric cancer but have not been fully clarified. Therefore, our goal was to identify the key miRNA-mRNA regulatory network in gastric cancer by utilizing a variety of bioinformatics analyses and experiments. A total of 242 miRNAs and 1080 genes were screened from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), respectively.

Identification and Validation of Ferroptosis-Related LncRNA Signatures as a Novel Prognostic Model for Colon Cancer.

Background: Ferroptosis is a newly defined form of programmed cell death that plays an important role in many cancers. However, ferroptosis-related lncRNAs (FRLs) involved in the regulation of colon cancer are not thoroughly understood. This study aimed to identify a prognostic FRL signature in colon cancer and explore its potential molecular function.

PTBP3 modulates P53 expression and promotes colorectal cancer cell proliferation by maintaining UBE4A mRNA stability.

The RNA binding protein PTBP3 was recently reported to play a critical role in multiple cancers, and the molecular mechanisms involved RNA splicing, 3' end processing and translation. However, the role of PTBP3 in colorectal cancer (CRC) remains poorly explored. Herein, PTBP3 was upregulated in CRC and associated with a poor prognosis.

Excess Folic Acid Supplementation before and during Pregnancy and Lactation Alters Behaviors and Brain Gene Expression in Female Mouse Offspring.

Use of folic acid (FA) during early pregnancy protects against birth defects. However, excess FA has shown gender-specific neurodevelopmental toxicity. Previously, we fed the mice with 2.