The Expression and Clinical Significance of SARM1 in Newly Diagnosed Acute Myeloid Leukemia.

Background: This study aimed to evaluate the expression level of SARM1 in the bone marrow of patients with newly diagnosed acute myeloid leukemia (AML) and assess its clinical and prognostic significance.

Methods: Bone marrow specimens were collected from 60 patients with newly diagnosed AML (observation group) and 20 healthy individuals (control group). Clinical and pathological characteristics of AML patients were recorded.

METTL7A is a potential biomarker for the diagnosis and prognosis of acute myeloid leukemia.

Background: Methyltransferase-like protein 7A (METTL7A), an m6A methyltransferase, is closely associated with various cancers, but its role in acute myeloid leukemia (AML) remains unclear.

Methods: This study employed bioinformatics analysis using the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) datasets. Furthermore, METTL7A expression levels in AML samples were validated using qRT-PCR.

[Recent Advances in Diagnosis and Treatment of Diffuse Alveolar Hemorrhage after Hematopoietic Stem Cell Transplantation --Review].

Diffuse alveolar hemorrhage (DAH) is a severe complication that can occur post- hematopoietic stem cell transplantation (HSCT). So far, the precise pathogenesis and risk factors of DAH post-HSCT remain elusive, diagnostic criteria have not reached a consensus, and the efficacy of existing therapeutic measures is far from satisfactory. At present, it is believed that the core mechanism of DAH post-HSCT is a vicious cycle initiated by endothelial injury, accompanied by a series of subsequent inflammatory and cellular responses.

Individualized model for predicting COVID-19 deterioration in patients with cancer: A multicenter retrospective study.

The 2019 novel coronavirus has spread rapidly around the world. Cancer patients seem to be more susceptible to infection and disease deterioration, but the factors affecting the deterioration remain unclear. We aimed to develop an individualized model for prediction of coronavirus disease (COVID-19) deterioration in cancer patients.

EGFR monoclonal antibody panitumumab inhibits chronic proliferative cholangitis by downregulating EGFR.

In hepatolithiasis, chronic proliferative cholangitis (CPC), an active and longstanding inflammation of stone‑containing bile ducts with enhanced mucin‑producing activity, not only affects the progression of the disease, it can also induce biliary carcinogenesis. The present study aimed to examine the effect of the epidermal growth factor receptor (EGFR) monoclonal antibody panitumumab (Pani) on CPC. Following the establishment of CPC rat models, periodic acid Schiff staining was used to observe the positive rate of EGFR expression.

Induction of cell death by pyropheophorbide-α methyl ester-mediated photodynamic therapy in lung cancer A549 cells.

Pyropheophorbide-α methyl ester (MPPa) was a promising photosensitizer with stable chemical structure, strong absorption, higher tissue selectivity and longer activation wavelengths. The present study investigated the effect of MPPa-mediated photodynamic treatment on lung cancer A549 cells as well as the underlying mechanisms. Cell Counting Kit-8 was employed for cell viability assessment.

[Reduced zinc concentration in expressed prostatic secretion relates to the pain symptoms of types â…¢ and â…£ prostatitis].

Objective: To determine the zinc levels in the expressed prostatic secretion (EPS) of the patients with different types of chronic nonbacterial prostatitis, and explore the reference value of zinc concentration in EPS in the diagnosis and treatment of prostatitis.

Methods: We collected EPS samples from 35 healthy men and 173 patients with chronic nonbacterial prostatitis, including 65 cases of type â…¢A, 69 cases of type â…¢B, and 39 cases of type â…£, according to the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). We compared the zinc levels in the EPS samples among different groups and analyzed the correlations of zinc concentration with the NIH-CPSI scores, WBC count, pH value, and age of the subjects.

[Value of Doppler echocardiography derived myocardial energy expenditure measurements in chronic heart failure patients].

Objective: To evaluate the relationship between myocardial energy expenditure (MEE) level and cardiac function in chronic heart failure (CHF) patients.

Methods: A total of 99 CHF patients were divided into 3 groups according to the LVEF (HFNEF > or = 50%, n = 37; HFREF1 35.1% - 49.

[Expression of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor in malignant melanoma].

Objective: To evaluate the expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) and their relationship in malignant melanoma.

Methods: 32 cases of malignant melanoma and 11 samples of normal skin were examined for HIF-1 alpha and VEGF expression by immunohistochemistry.

Results: The expression rate of HIF-1 alpha and VEGF was 62.

Value of echocardiography for observing left ventricular hypertrophy in the diagnosis of myocardial microvascular damage in hypertensives.

Objective: To investigate the value of the echocardiographic observation of the left ventricular hypertrophy (LVH) in diagnosing myocardial microvascular damage in patients with essential hypertension (EH).

Methods: After intravenous injection with Quanfuxian (a contrast agent consisting of albumin and C3F8 prepared by Nanfang Hospital), the values of A (the maximum number of microbubbles accumulating in the local tissues for assessing the density of local microvessels), beta (the filling velocity of contrast agent for evaluating local blood flow velocity) and A x beta (the product of A and beta for estimating local myocardial blood flow) at rest and after dipyridamole injection were measured by intermittent harmonic imaging with myocardial contrast echocardiography (MCE). The ratios of A and beta along with the microvascular coronary flow velocity reserve (CFVR) were also calculated.

[Clinical value of emergency bedside ultrasonocardiogram in cardiac care unit].

Objective: To evaluate the clinical value of application of emergency bedside ultrasound cardiogram (UCG) in cardiac intensive care unit.

Methods: We conducted a retrospective analysis of 116 cases who received examination with emergency bedside UCG within the period from April 2000 to March 2001.

Results: The positivity rate of examination with emergency bedside UCG was 100% among these patients.

[Echocardiographical features during the rejection free period after heart transplantation: report of one case].

Objective: To study the echocardiographic features during the period free of acute allograft rejection after heart transplantation by monitoring one patient within one year after heart transplantation.

Methods: The dimension of atrial and ventricular, interventricular septal and ventricular wall thickness, blood flow pattern through the mitral and tricuspid valves, left ventricular muscle weight (LVMW) and LVMW index during different periods were measured by echocardiography, and all these data were compared with those of the donor before operation.

Results: The patient recovered well without any signs of acute rejection.