Dissecting Social Working Memory: Neural and Behavioral Evidence for Externally and Internally Oriented Components.

Social working memory (SWM)-the ability to maintain and manipulate social information in the brain-plays a crucial role in social interactions. However, research on SWM is still in its infancy and is often treated as a unitary construct. In the present study, we propose that SWM can be conceptualized as having two relatively independent components: "externally oriented SWM" (e-SWM) and "internally oriented SWM" (i-SWM).

Commentary: The association between uric acid to high-density cholesterol ratio and depression: A population-based cross-sectional study.

This commentary examines the recent findings by Wang et al. (2025) on the association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and depression in a U.S.

Toward Targeted Mining of RFM Patterns.

In today's era of information overload, leveraging data mining techniques to understand and analyze customer behavior has become essential for businesses. Among these techniques, the recency, frequency, and monetary value analysis model serves as a powerful tool for customer segmentation, enabling companies to identify high-value customers. However, traditional recency, frequency, and monetary (RFM) models do not focus on user-specific targets, often struggling to meet the increasing demands for personalization and efficiency.

Runtime Analysis of Typical Decomposition Approaches in MOEA/D for Many-Objective Optimization Problems.

Decomposition-based multi-objective evolutionary algorithms (MOEAs) are popular methods utilized to address many-objective optimization problems (MaOPs). These algorithms decompose the original MaOP into several scalar optimization subproblems, and solve them to obtain a set of solutions to approximate the Pareto front (PF). The decomposition approach is an important component in them.

Pan-cancer analysis reveals age-associated genetic alterations in protein domains.

Cancer incidence and mortality differ among individuals of different ages, but the functional consequences of genetic alterations remain largely unknown. We systematically characterized genetic alterations within protein domains stratified by affected individual's age and showed that the mutational effects on domains varied with age. We further identified potential age-associated driver genes with hotspots across 33 cancers.

Robust Plasma-Assisted Growth of 2D Janus Transition Metal Dichalcogenides and Their Enhanced Photoluminescent Properties.

Janus transition metal dichalcogenides (TMDs) are a novel class of 2D materials with unique mirror asymmetry. Plasma-assisted synthesis at room temperature is favored for producing Janus TMDs due to its energy efficiency and prevention of alloying. However, current methods require stringent control over growth conditions, risking defects or unintended materials.

Controlling of Crystal Facets by Dysprosium-Modified WO/Carbon Nanofibers Enhance the Flexible Supercapacitor Performance.

Dysprosium-modified tungsten oxide/carbon nanofibers (Dy-WO/PCNFs) are fabricated via electrospinning combined with high-temperature calcination to synthesize a flexible, self-supporting electrode material that does not require a conductive agent or binder. XRD and TEM analyses showed that introducing dysprosium promoted the preferential growth of WO crystals along the preponderance crystal planes involved in the electrochemical reaction, enhancing the exposure of the (002) and (200) crystal planes. Furthermore, DFT calculations demonstrated that the incorporation of Dy resulted in enhanced adsorption of Dy-WO by PCNFs, with an adsorption energy of -1.

Aptamer functionalized hypoxia-potentiating agent and hypoxia-inducible factor inhibitor combined with hypoxia-activated prodrug for enhanced tumor therapy.

Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer. Hypoxia-activated prodrugs (HAPs) have shown promise as potential therapeutic agents for TNBC. While increasing hypoxia levels may promote the HAP activation, it raises concerns regarding HIF1α-dependent drug resistance.

Advancing targeted combination chemotherapy in triple negative breast cancer: nucleolin aptamer-mediated controlled drug release.

Background: Triple-negative breast cancer (TNBC) is a recurrent, heterogeneous, and invasive form of breast cancer. The treatment of TNBC patients with paclitaxel and fluorouracil in a sequential manner has shown promising outcomes. However, it is challenging to deliver these chemotherapeutic agents sequentially to TNBC tumors.

Deterministic Areal Enhancement of Interlayer Exciton Emission by a Plasmonic Lattice on Mirror.

The emergence of interlayer excitons (IX) in atomically thin heterostructures of transition metal dichalcogenides (TMDCs) has drawn great attention due to their unique and exotic optical and optoelectronic properties. Because of the spatially indirect nature of IX, its oscillator strength is 2 orders of magnitude smaller than that of the intralayer excitons, resulting in a relatively low photoluminescence (PL) efficiency. Here, we achieve the PL enhancement of IX by more than 2 orders of magnitude across the entire heterostructure area with a plasmonic lattice on mirror (PLoM) structure.

Polystyrene nanoplastics and cadmium co-exposure aggravated cardiomyocyte damage in mice by regulating PANoptosis pathway.

Micro/nanoplastics (M/NPs) are the novel contaminants ubiquitous in the environment. Cadmium (Cd), a kind of heavy metal pollutant widely distributed, could potentially co-exist with PS-NPs in the environment. However, their combined effects on cardiomyocyte and its molecular mechanism in mammals remained ambiguous.

Unique quinoline orientations shape the modified aptamer to sclerostin for enhanced binding affinity and bone anabolic potential.

Osteogenesis imperfecta (OI) is a rare genetic disease characterized by bone fragility and bone formation. Sclerostin could negatively regulate bone formation by antagonizing the Wnt signal pathway, whereas it imposes severe cardiac ischemic events in clinic. Our team has screened an aptamer that could promote bone anabolic potential without cardiovascular risk.

Transition from positive to negative indirect CO effects on the vegetation carbon uptake.

Although elevated atmospheric CO concentration (eCO) has substantial indirect effects on vegetation carbon uptake via associated climate change, their dynamics remain unclear. Here we investigate how the impacts of eCO-driven climate change on growing-season gross primary production have changed globally during 1982-2014, using satellite observations and Earth system models, and evaluate their evolution until the year 2100. We show that the initial positive effect of eCO-induced climate change on vegetation carbon uptake has declined recently, shifting to negative in the early 21st century.

Precisely constructing hybrid nanogap arrays via wet-transfer of dielectric metasurfaces onto a plasmonic mirror.

We propose a new method for fabricating hybrid metasurfaces by combining Mie and plasmonic resonances. Our approach involves obtaining an ultrasmooth gold film and separately structuring monocrystalline silicon (c-Si) nanoantenna arrays, which are then wet-transferred and finally immobilized onto the gold film. The experimental and simulation analysis reveals the importance of the native oxide layer of Si and demonstrates fascinating dispersion curves with nanogap resonances and bound states in the continuum.

Apolipoprotein B is associated with CT-angiographic progression beyond low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in patients with coronary artery disease.

Background: Accumulating evidence indicated that apolipoprotein B (apoB) was the principal lipid determinant of coronary artery disease (CAD). Nevertheless, the connection between apoB and angiographic progression of CAD remained undetermined.

Methods: Five hundred and forty-four CAD patients with twice coronary computed tomography angiography experiences were enrolled.

Dual Control of Enhanced Quasi-Bound States in the Continuum Emission from Resonant c-Si Metasurfaces.

Optical bound states in the continuum (BICs) offer strong interactions with quantum emitters and have been extensively studied for manipulating spontaneous emission, lasing, and polariton Bose-Einstein condensation. However, the out-coupling efficiency of quasi-BIC emission, crucial for practical light-emitting devices, has received less attention. Here, we report an adaptable approach for enhancing quasi-BIC emission from a resonant monocrystalline silicon (c-Si) metasurface through lattice and multipolar engineering.

Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway.

Roof plate-specific spondin 1 (R-spondin1, RSPO1) is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway, which is key to hair regeneration. However, it is not clear whether recombinant RSPO1 (rRSPO1) affects hair regeneration. Here, we treat C57BL/6 male mice with rRSPO1 and investigate the expression of the Wnt/β-catenin signaling pathway and the activation of hair follicle stem cells in the dorsal skin.

Contact-engineered reconfigurable two-dimensional Schottky junction field-effect transistor with low leakage currents.

Two-dimensional (2D) materials have been considered promising candidates for future low power-dissipation and reconfigurable integrated circuit applications. However, 2D transistors with intrinsic ambipolar transport polarity are usually affected by large off-state leakage currents and small on/off ratios. Here, we report the realization of a reconfigurable Schottky junction field-effect transistor (SJFET) in an asymmetric van der Waals contact geometry, showing a balanced and switchable n- and p-unipolarity with the I on/off ratio kept >10.

Plasmonic Bound States in the Continuum to Tailor Exciton Emission of MoTe.

Plasmon resonances can greatly enhance light-matter interactions of two-dimensional van der Waals materials. However, the quality factor of plasmonic resonances is limited. Here, we demonstrate a plasmonic quasi-bound state in the continuum (quasi-BIC), which is composed of gold nanorod pairs.

Multifunctional CuFeO@HA as a GSH-depleting nanoplatform for targeted photothermal/enhanced-chemodynamic synergistic therapy.

Chemodynamic therapy (CDT), which converts overexpressed hydrogen peroxide (HO) in tumor cells to hydroxyl radicals (•OH) by Fenton reactions, is considered a prospective strategy in anticancer therapy. However, the high level of glutathione (GSH) and poor Fenton catalytic efficiency contribute to the suboptimal efficiency of CDT. Herein, we present a multifunctional nanoplatform (CuFeO@HA) that can induce GSH depletion and combine with photothermal therapy (PTT) to enhance antitumor efficacy.

Design and Embedded Implementation of Secure Image Encryption Scheme Using DWT and 2D-LASM.

In order to further improve the information effectiveness of digital image transmission, an image-encryption algorithm based on 2D-Logistic-adjusted-Sine map (2D-LASM) and Discrete Wavelet Transform (DWT) is proposed. First, a dynamic key with plaintext correlation is generated using Message-Digest Algorithm 5 (MD5), and 2D-LASM chaos is generated based on the key to obtain a chaotic pseudo-random sequence. Secondly, we perform DWT on the plaintext image to map the image from the time domain to the frequency domain and decompose the low-frequency (LF) coefficient and high-frequency (HF) coefficient.

Inhibiting Osteolytic Breast Cancer Bone Metastasis by Bone-Targeted Nanoagent via Remodeling the Bone Tumor Microenvironment Combined with NIR-II Photothermal Therapy.

Bone is one of the prone metastatic sites of patients with advanced breast cancer. The "vicious cycle" between osteoclasts and breast cancer cells plays an essential role in osteolytic bone metastasis from breast cancer. In order to inhibit bone metastasis from breast cancer, NIR-II photoresponsive bone-targeting nanosystems (CuP@PPy-ZOL NPs) are designed and synthesized.

The atypical ubiquitin ligase RNF31 stabilizes c-Myc via epigenetic inactivation of FBXO32 and promotes cancer development.

RNF31, an atypical E3 ubiquitin ligase of the RING-between-RING protein family, is one of the important components of the linear ubiquitin chain complex LUBAC. It plays a carcinogenic role in a variety of cancers by promoting cell proliferation, invasion and inhibiting apoptosis. However, the specific molecular mechanism by which RNF31 exerts its cancer-promoting effects is still unclear.