Cys-Ala-Gly Peptides and Amphiphilic mPEG-PLGA Polymer Modified ZE21B Magnesium Alloy for Enhanced Anticorrosion and Pro-Endothelialization Potential.

Magnesium alloy stents (MASs) provide significant therapeutic benefits for the treatment of cardiovascular disease. Unlike conventional permanent stents, MASs gradually degrade after fulfilling their mechanical support function, thereby reducing the risk of long-term complications. However, the clinical application of MAS is hindered by two primary challenges: excessively rapid degradation in physiological environments and inadequate biocompatibility resulting from the alloy's corrosion behavior.

Chondroitin sulfate and Cys-Ala-Gly peptides coated ZE21B magnesium alloy for enhanced corrosion resistance and vascular compatibility.

Coronary stents are widely used in the interventional treatment of cardiovascular disease. Biodegradable magnesium alloy stents are ideal candidates to replace traditional non-biodegradable stents due to their excellent mechanical properties and biodegradation. However, too fast degradation and poor biocompatibility limit the further clinical application of magnesium alloy stents.