Publications by authors named "Yuki Sahashi"

Background: Accurate measurement of echocardiographic parameters is crucial for the diagnosis of cardiovascular disease and tracking of change over time; however, manual assessment requires time-consuming effort and can be imprecise. Artificial intelligence has the potential to reduce clinician burden by automating the time-intensive task of comprehensive measurement of echocardiographic parameters.

Objectives: The purpose of this study was to develop and validate open-sourced deep learning semantic segmentation models for the automated measurement of 18 anatomic and Doppler measurements in echocardiography.

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Introduction: Cardiac rehabilitation (CR) improves the outcomes of patients with chronic heart disease. However, participation in hospital-based programs is limited, partly because of accessibility issues. Notably, most CRs are performed unsupervised at home, making it challenging for healthcare providers and patients to monitor progress accurately or provide tailored feedback.

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Background: Intravascular ultrasound (IVUS)-based tissue characterization has been used to detect vulnerable plaque or lipid-rich plaque (LRP). Recently, advancements in artificial intelligence (AI) technology have enabled automated coronary arterial plaque segmentation and tissue characterization. The purpose of this study was to evaluate the feasibility and diagnostic accuracy of a deep learning model for plaque segmentation, tissue characterization and identification of LRP.

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Background: Echocardiography is the most common modality for assessing cardiac structure and function. Although cardiac magnetic resonance (CMR) imaging is less accessible, it can provide unique tissue characterization, including late gadolinium enhancement (LGE), T1 and T2 mapping, and extracellular volume (ECV), which are associated with tissue fibrosis, infiltration, and inflammation. Deep learning has been shown to uncover findings not recognized by clinicians, but it is unknown whether CMR-based tissue characteristics can be derived from echocardiographic videos using deep learning.

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Introduction: Left ventricular diastolic dysfunction (LVDD) is most commonly evaluated by echocardiography. However, without a sole identifying metric, LVDD is assessed by a diagnostic algorithm relying on secondary characteristics that is laborious and has potential for interobserver variability.

Methods: To characterize concordance in clinical evaluations of LVDD, we evaluated historical echocardiogram studies at two academic medical centers for variability between clinician text reports and assessment by 2016 American Society of Echocardiography (ASE) guidelines.

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Accurate understanding of biological aging and the impact of environmental stressors is crucial for understanding cardiovascular health and identifying patients at risk for adverse outcomes. Chronological age stands as perhaps the most universal risk predictor across virtually all populations and diseases. While chronological age is readily discernible, efforts to distinguish between biologically older versus younger individuals can, in turn, potentially identify individuals with accelerated versus delayed cardiovascular aging.

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Background: Accurate measurement of echocardiographic parameters is crucial for the diagnosis of cardiovascular disease and tracking of change over time, however manual assessment is time-consuming and can be imprecise. Artificial intelligence (AI) has the potential to reduce clinician burden by automating the time-intensive task of comprehensive measurement of echocardiographic parameters.

Methods: We developed and validated open-sourced deep learning semantic segmentation models for the automated measurement of 18 anatomic and Doppler measurements in echocardiography.

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Background: Accurate evaluation of aortic regurgitation (AR) severity is necessary for early detection and chronic disease management. AR is most commonly assessed by Doppler echocardiography, however limitations remain given variable image quality and need to integrate information from multiple views. This study developed and validated a deep learning model for automated AR severity assessment from multi-view color Doppler videos.

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Echocardiography, which provides detailed evaluations of cardiac structure and pathology, is central to cardiac imaging. Traditionally, the assessment of disease severity, treatment effectiveness, and prognosis prediction relied on detailed parameters obtained by trained sonographers and the expertise of specialists, which can limit access and availability. Recent advancements in deep learning and large-scale computing have enabled the automatic acquisition of parameters in a short time using vast amounts of historical training data.

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Background: Rate-adaptive pacing (RAP) complements heart rate (HR) responses in patients with cardiac pacing devices and chronotropic incompetence, although improvements in exercise capacity have varied across reported studies. The purpose of this study was to evaluate the effectiveness of the RAP mode across different clinical settings.

Methods: A systematic review and meta-analysis were conducted according to PRISMA guidelines.

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Background: Timely and accurate detection of pericardial effusion and assessment cardiac tamponade remain challenging and highly operator dependent.

Objectives: Artificial intelligence has advanced many echocardiographic assessments, and we aimed to develop and validate a deep learning model to automate the assessment of pericardial effusion severity and cardiac tamponade from echocardiogram videos.

Methods: We developed a deep learning model (EchoNet-Pericardium) using temporal-spatial convolutional neural networks to automate pericardial effusion severity grading and tamponade detection from echocardiography videos.

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Article Synopsis
  • * Researchers analyzed X-posting rates and journal viewership data from April 2022 to September 2023, noting a significant increase in both after protocol changes made in March 2023.
  • * The findings suggested that adopting the new X-posting strategy led to more article views, indicating a positive impact on viewer access.
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Backgrounds & Aims: This study aimed to investigate the association between vitamin D deficiency and covert hepatic encephalopathy (CHE), overt hepatic encephalopathy (OHE) occurrence, and mortality in patients with cirrhosis.

Methods: This retrospective study reviewed 679 patients with cirrhosis. Vitamin D deficiency was defined as serum 25-hydorxyvitamin D (25-OHD) levels < 20 ng/mL.

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Article Synopsis
  • Chronic liver disease affects over 1.5 billion adults globally, but most cases are asymptomatic, leading to high rates of undiagnosed individuals.
  • The study aims to create a deep learning algorithm that analyzes echocardiography videos for opportunistic screening of chronic liver disease like cirrhosis and steatotic liver disease (SLD).
  • The resulting model, called EchoNet-Liver, successfully identified cirrhosis and SLD in multiple test cohorts, showing promising areas under the curve (AUC) for diagnostic accuracy, indicating its potential effectiveness in clinical settings.
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Background: Risk stratification for patients with non-ischemic cardiomyopathy (NICM) remains challenging as previous studies predicting life-threatening ventricular arrhythmia (LTVA) events were conducted before the establishment of the current standard treatment. We investigated the prognostic value of non-sustained ventricular tachycardia (NSVT) in NICM patients among recent studies.

Methods: MEDLINE, Embase were searched from January 2000 to October 2023.

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Article Synopsis
  • Echocardiography is widely used for evaluating heart structure and function, but cardiac magnetic resonance (CMR) imaging offers detailed tissue analysis, including fibrosis and inflammation indicators, which may not be detectable by traditional methods.
  • A study was conducted where a deep learning model was trained on echocardiography videos of patients who had both echocardiograms and CMRs to predict certain CMR measures like wall motion abnormalities and tissue characteristics.
  • The model successfully predicted wall motion abnormalities with high accuracy but struggled with detecting other important tissue characteristics, indicating that such information might not be captured in echocardiography videos and highlighting the continuing importance of CMR for assessing heart tissue.
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Alcohol septal ablation (ASA) is performed for symptomatic drug-refractory hypertrophic obstructive cardiomyopathy to reduce the left ventricular outflow tract pressure gradient (LVOTPG) by injecting ethanol into a septal branch that perforates the septal bulge. The target septal branches usually arise directly from the left anterior descending (LAD) artery; however, vessels from a non-LAD artery can be selected in some cases. This study aimed to compare the effectiveness and safety between ASA performed using a septal branch arising from a non-LAD artery and a branch arising from the LAD artery.

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Background: Subcutaneous implantable cardioverter defibrillators (S-ICDs) are occasionally used in combination with other cardiac implantable electronic devices (CIEDs). However, whether the incidence of inappropriate shock increases in patients with S-ICDs and concomitant CIEDs remains unclear. This study aimed to investigate the association between the concomitant use of CIEDs and the incidence of inappropriate shock in patients with current-generation S-ICDs.

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Article Synopsis
  • * Results showed that while the accuracy of detecting regional wall-motion abnormalities (RWMAs) improved slightly with the slow-motion technique (87.5%) compared to conventional ESE (81.0%), this difference was not statistically significant.
  • * The new method demonstrated enhanced image readability and better interreader agreement among cardiologists, suggesting it could be a beneficial tool to assist physicians in evaluations, despite the accuracy not being significantly improved.
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Previous research has investigated the effectiveness of the "Tweet the Meeting" campaign, but the relationship between tweet content and the number of retweets has not been fully evaluated. We analyzed the number of tweets and retweets during the Japanese Circulation Society's 2022 annual meeting. The ambassador group had significantly more session- and symposium-related tweets than the non-ambassador group (P<0.

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Article Synopsis
  • The study compares two strategies for adjusting dual antiplatelet therapy (DAPT) after acute coronary syndrome: unguided de-escalation (switching to less potent medication) and personalized guided selection (using genetic or platelet function tests).
  • They analyzed data from 19 trials involving nearly 70,000 patients to determine the effectiveness and safety of each strategy, focusing on major cardiovascular events and bleeding risks.
  • Findings suggest that unguided de-escalation reduces bleeding risks without increasing major cardiovascular event risks, making it potentially a safer approach compared to guided selection strategies.
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Background: Given the reduction in periprocedural complication rates, same-day discharge (SDD) after percutaneous left atrial appendage closure (LAAC) could be beneficial. To date, little data exist comparing the standard overnight stay (ONS) vs SDD after LAAC.

Objective: The purpose of this study was to investigate the safety and efficacy of SDD compared with ONS.

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Background: A dose-response and nonlinear association between fruit and vegetable intake and mortality has been reported in Europe and the United States, but little is known about this association in Asia.

Objectives: This study aimed to evaluate the association of fruit and vegetable intake with all-cause, cancer, cardiovascular, and respiratory disease mortality in a Japanese cohort.

Methods: In the Japan Public Health Center-based prospective study, we included 94,658 participants (mean age: 56.

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Idiopathic left ventricular tachycardia is macro-reentrant tachycardia involving the fascicles in the left ventricle as a part of its reentrant circuit. The detailed circuit mechanisms somewhat remain unclear. We reported QRS and cycle length alternans confirmed after the first application of radiofrequency delivery for the distal site of left posterior fascicle potential (P2) in a patient with idiopathic left ventricular tachycardia.

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