Publications by authors named "Yuki Ogasahara"
Aim: Sarcopenia is a prevalent comorbidity among older patients with heart failure. This study aimed to evaluate the differences between sarcopenia diagnosed using the Asian Working Group for Sarcopenia (AWGS) 2014 and 2019 criteria in older patients with heart failure.
Methods: This study is a post hoc sub-analysis of data from the FRAGILE-HF study, a prospective, multicenter, observational study.
Aims: The prevalence and impact of cardiovascular, kidney, and metabolic (CKM) overlap on physical function and prognosis in older patients with heart failure (HF) remain unclear. This study aimed to assess the impact of overlapping CKM conditions on physical function and prognosis in older patients with HF.
Methods: This post-hoc analysis of the FRAGILE-HF (main cohort) and SONIC-HF (validation cohort), both prospective multicentre studies, included patients aged ≥65 years who were hospitalised for HF.
Aims: The benefits of exercise in patients with heart failure are well documented. However, to date, the association between exercise habits and prognosis is yet to be evaluated. In this study, we investigated the association between pre-hospital exercise habits and post-discharge prognosis in older adult patients with heart failure.
View Article and Find Full Text PDFObjectives: The Asian Working Group for Sarcopenia in 2019 (AWGS 2019) emphasized muscle mass measurements. In contrast, the Sarcopenia Definitions and Outcomes Consortium (SDOC) prioritizes functional strength and mobility. Therefore, this study aimed to compare the prognostic utility of the SDOC and AWGS 2019 criteria for all-cause mortality in older patients with heart failure.
View Article and Find Full Text PDFPrevalence and Prognostic Value of Cachexia Diagnosed by New Definition for Asian People in Older Patients With Heart Failure.
J Cachexia Sarcopenia Muscle
December 2024
Article Synopsis
- The study explores the prevalence of cachexia, sarcopenia, and malnutrition in older patients with heart failure (HF) using definitions from the Asian Working Group for Cachexia (AWGC) and other criteria, finding that AWGC-defined cachexia was the most common condition.
- Among the 861 patients analyzed, cachexia was present in 74.1%, while other conditions showed lower prevalence rates.
- The results indicated that AWGC-defined cachexia was not significantly linked to all-cause mortality in these patients, contrasting with stronger associations found for cachexia according to Evans' criteria, sarcopenia, and malnutrition.
Overlap of frailty and malnutrition as prognosticators in older patients with heart failure.
Am Heart J Plus
October 2024
Article Synopsis
- Older patients (65+) with heart failure (HF) often experience physical frailty and malnutrition, which can worsen each other and lead to poor health outcomes.
- A study involving 862 hospitalized patients found that those with both frailty and malnutrition had the highest risk of death within a year of discharge compared to those with neither condition.
- Identifying and addressing both frailty and malnutrition in these patients is essential for improving their overall health and survival rates.
Prognostic value of Borg scale following 6-min walk test in hospitalized older patients with heart failure.
Eur J Prev Cardiol
December 2024
Aims: The 6-min walk test (6MWT) is a widely accepted tool for evaluating exercise tolerance and physical capacity, and the 6-min walk distance (6MWD) is an established prognostic factor in patients with heart failure (HF). However, the prognostic implications of post-6MWT dyspnoea remain unknown. We aimed to investigate the prognostic value of Borg scores after the 6MWT in patients with HF.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluated the validity of the AWGS 2019 criteria for diagnosing sarcopenia in heart failure patients and proposed a modified model incorporating the 6-minute walk test (6MWT) for better risk stratification.
- The modified model identified sarcopenia and severe sarcopenia differently than the original, detecting more cases, and showed a stronger link to 2-year mortality rates.
- Findings suggest that using the 6MWT enhances the ability to assess risk in patients with heart failure, indicating a need to revise current criteria for timely treatment decisions.
Aims: In heart failure (HF), inflammation is linked to malnutrition and impaired physical function. In this study, we aimed to assess how novel nutritional-inflammatory markers and lymphocyte-to-C-reactive protein ratio (LCR) and score (LCS) are associated with the nutritional status, physical function, and prognosis of patients with HF.
Methods And Results: This study was a secondary analysis of the FRAGILE-HF study, a prospective observational study conducted across 15 hospitals in Japan.
Background: Social factors encompass a broad spectrum of nonmedical factors, including objective (social isolation [SI]) and perceived (loneliness) conditions. Although social factors have attracted considerable research attention, information regarding their impact on patients with heart failure is scarce. We aimed to investigate the prognostic impact of objective SI and loneliness in older patients with heart failure.
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- The study examined how common bendopnea is in older heart failure patients and its impact on their prognosis.
- Bendopnea was found in 2.5% of patients in the main study group and 4.4% in the validation group, with a higher risk of death over two years for those with this condition.
- The results indicate that bendopnea is a meaningful predictor of all-cause mortality, even when accounting for other risk factors.
Impact of Multidomain Frailty on the Mode of Death in Older Patients With Heart Failure: A Cohort Study.
Circ Cardiovasc Qual Outcomes
May 2024
Article Synopsis
- Frailty in elderly heart failure patients correlates with overall mortality, but specific causes of death remain underexplored, prompting further investigation into multidomain frailty's role.
- The study analyzed 1,181 hospitalized patients, finding that as frailty increased (measured across physical, social, and cognitive domains), so did the risk of death, particularly from noncardiovascular causes.
- Results indicated that patients with higher frailty scores (2 or 3 domains) had a significantly increased risk of noncardiovascular death, while the association was not as strong for heart failure or other cardiovascular deaths.
Aims: MitraScore is a novel, simple, and manually calculatable risk score developed as a prognostic model for patients undergoing transcatheter edge-to-edge repair (TEER) for mitral regurgitation. As its components are considered prognostic in heart failure (HF), we aimed to investigate the usefulness of the MitraScore in HF patients.
Methods And Results: We calculated MitraScore for 1100 elderly patients (>65 years old) hospitalized for HF in the prospective multicentre FRAGILE-HF study and compared its prognostic ability with other simple risk scores.
Background: Frailty is associated with a poor prognosis in older patients with heart failure (HF). However, multidomain frailty assessment tools have not been established in patients with HF, and the association between the frailty phenotype and the deficit-accumulation frailty index in these patients is unclear. We aimed to understand this relationship and evaluate the prognostic value of the deficit-accumulation frailty index in older patients with HF.
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- Researchers aimed to evaluate the Ishii score, which considers age, grip strength, and calf circumference, to predict sarcopenia and its potential impact on 1-year mortality in heart failure patients.
- In a study with 1262 participants, 936 were assessed for sarcopenia, finding that 184 had the condition, with the Ishii score demonstrating good predictive accuracy, especially for men (0.87) compared to women (0.73).
- The results indicated that a higher Ishii score was linked to increased 1-year mortality rates, making it a valuable tool for identifying at-risk older heart failure patients.
Prognostic impact of cachexia by multi-assessment in older adults with heart failure: FRAGILE-HF cohort study.
J Cachexia Sarcopenia Muscle
October 2023
Background: Cachexia substantially impacts the prognosis of patients with heart failure (HF); however, there is no standard method for cachexia diagnosis. This study aimed to investigate the association of Evans's criteria, consisting of multiple assessments, with the prognosis of HF in older adults.
Methods: This study is a secondary analysis of the data from the FRAGILE-HF study, a prospective multicentre cohort study that enrolled consecutive hospitalized patients aged ≥65 years with HF.
Article Synopsis
- The study investigated the overlap between cachexia and sarcopenia in older heart failure patients, finding that 32.7% had cachexia and 22.7% had sarcopenia, with 11% experiencing both conditions.* -
- Among the participants, those with both cachexia and sarcopenia had the highest death rates (17.5% over two years) and were identified as an independent risk factor for mortality.* -
- The findings indicate that while both conditions are common in older heart failure patients, the degree of overlap is less significant than expected, highlighting the need for patient awareness and targeted interventions.*
Article Synopsis
- The study investigates the predictive power of the six-minute walking test in patients with heart failure and preserved ejection fraction (HFpEF), focusing on its significance beyond traditional risk factors.
- It involved 513 older patients, with a follow-up period of two years, revealing that those who walked less than 166 meters had the highest mortality rate.
- The findings indicate that the six-minute walking distance is a valuable prognostic tool, improving the accuracy of survival predictions in HFpEF patients.
Aims: Frailty is highly prevalent and associated with poor prognoses in elderly patients with heart failure (HF). However, the potential effects of physical frailty on the benefits of HF medications in elderly patients with HF are unclear. We aimed to determine the influence of physical frailty on the prognosis of HF medications in elderly patients with HF with reduced and mildly reduced ejection fraction (HFr/mrEF).
View Article and Find Full Text PDFAims: Functional decline due to skeletal muscle abnormalities leads to poor outcomes in patients with acute heart failure (AHF). The 6-minute walking test (6MWT) reliably evaluates functional capacity, but its technical difficulty for the elderly often limits its benefits. Although the Short Physical Performance Battery (SPPB) is a comprehensive measure of physical performance, its role in AHF remains unclear.
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- The study aimed to explore how common sarcopenic obesity is among older heart failure patients, its link to physical fitness and frailty, and its impact on survival.
- Researchers analyzed data from 779 hospitalized older adults, finding that 19.3% had sarcopenia and 26.2% were classified as obese, with specific cutoff points for body fat.
- Results indicated that those with both sarcopenia and obesity had poorer physical performance and a significantly higher risk of death within a year, establishing sarcopenic obesity as a serious health concern in this group.
Article Synopsis
- The study investigates the prevalence and prognostic impact of cognitive frailty in elderly heart failure (HF) patients, highlighting its significance for long-term outcomes.
- Conducted on 1215 patients aged 65 and older, findings revealed that 23% displayed cognitive frailty, linked to a higher risk of mortality and rehospitalization.
- The results showed that cognitive frailty increased the risk of adverse events by 1.55 times, emphasizing the importance of monitoring both cognitive and physical health in older patients with HF.
Aims: A patient's understanding of his or her own comorbidities is part of the recommended patient education for those with heart failure. The accuracy of patients' understanding of their comorbidities and its prognostic impact have not been reported.
Methods And Results: Patients hospitalized for heart failure (n = 1234) aged ≥65 years (mean age: 80.
Sex differences in the prevalence and prognostic impact of physical frailty and sarcopenia among older patients with heart failure.
Nutr Metab Cardiovasc Dis
February 2022
Article Synopsis
- Frailty and sarcopenia are prevalent issues in elderly heart failure patients, with higher rates seen in women for frailty and in men for sarcopenia.
- Both conditions significantly impact the risk of 1-year mortality in heart failure patients, although frailty specifically predicted mortality only in men.
- The study found no significant gender interactions influencing the prognostic impact of frailty or sarcopenia, emphasizing that both conditions are detrimental for older patients regardless of sex.
Background: No reports explicitly examined the relationship between work defined as a certain type of social participation or role and the protective effect on the prognosis of patients with heart failure (HF) by preventing frailty. Therefore, this study examined whether social participation through work before admission relates to future adverse events in HF patients aged ≥65 years, and whether each frailty domain mediates the association between work and prognosis as a second analysis of a multi-centered prospective study (FRAGILE-HF study).
Methods: We retrospectively reviewed 1,332 older patients with HF whose work status before admission to the hospital were investigated.