pH-modulated synthesis of multicolor carbon dots from Perilla leaves for dual-mode room-temperature fluorescence and phosphorescence applications.

Biomass materials represent an ideal carbon source for synthesizing carbon dots (CDs) due to their abundance, elemental diversity, renewability, and low cost. This study presents a straightforward solvothermal method for synthesizing polychromatic carbon dots (MCDs) by systematically adjusting the reaction parameters using biomass-derived precursors (Perilla fruits leaves and tea polyphenols) under pH-modulated conditions (pH 2-13). The MCDs show tunable emission (395-646 nm), overcoming the traditional blue/green limitation of biomass-derived CDs.

Precision-engineered magnetic/plasmonic heterodimers for naked-eye and photothermal mpox virus diagnostics.

The global surge of mpox virus (MPXV) demands diagnostic tools that combine laboratory-grade accuracy with point-of-care simplicity. Here, we report an all-in-one lateral flow immunoassay (LFIA) leveraging precision-engineered FeO-Au heterodimers for dual-signal MPXV quantification via naked-eye readout and photothermal amplification. These monodisperse plasmonic-magnetic nanoparticles, synthesized through controlled seed-mediated heterodimerization, integrate magnetic enrichment, photothermal conversion, and tunable plasmonic resonance into a single architecture.

A highly sensitive and fast-response fluorescence nanoprobe for in vivo imaging of hypochlorous acid.

Fluorescent probes for in vivo hypochlorous acid (HClO) imaging often face challenges of low selectivity and high cytotoxicity, largely due to poor analyte recognition and water-insoluble aromatic skeletons. To address this, we synthesized fluorescein hydrazide by introducing a spiro-lactam unit into fluorescein, which offers high emission intensity and molar absorption. The five-membered heterocycle in fluorescein hydrazide is selectively disrupted by HClO, enhancing the conjugated system and electron delocalization of the fluorophore, resulting in highly sensitive fluorescence detection of HClO.

[Mechanism of WAVE1 regulation of lipopolysaccharide-induced mitochondrial metabolic abnormalities and inflammatory responses in macrophages].

Objectives: To explore the mechanism by which Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 (WAVE1) regulates lipopolysaccharide (LPS)-induced mitochondrial metabolic abnormalities and inflammatory responses in macrophages.

Methods: Macrophage cell lines with overexpressed WAVE1 (mouse BMDM and human THP1 cells) were prepared. The macrophages were treated with LPS (500 ng/mL) to simulate sepsis-induced inflammatory responses.

Exploring the microbial ecosystem of var. : a comprehensive analysis of endophytes and rhizospheric soil microorganisms.

Endophytic and rhizospheric microorganisms associated with plants play a crucial role in plant health, pest and disease defense, and fruit yield by actively participating in the plant's adaptation to its environment. In this study, high-throughput sequencing technology was employed to analyze the community structure and diversity of endophytic and rhizospheric soil microorganisms in var. .

Acute and subchronic toxicity and the evaluation of safety pharmacology of Chinese herbal compound preparation "Shikuqin".

"Shikuqin" (SKQ) powder consists of three Chinese herbs: Punica granatum L, Sophora flavescens Ait, and Fraxinus rhynchophylla Hance. SKQ has been used for the treatment of diarrhea. In order to provide a comprehensive understanding of toxicity, the acute and sub-chronic toxicity and safety pharmacology of SKQ were evaluated in the present study.