TabsPBP2, a Pheromone-Binding Protein Highly Expressed in Male Antennae of , Binds Sex Pheromones and Tomato Volatiles.

The tomato leafminer (), a globally invasive pest, poses a major economic threat to tomato production. Although chemical control remains the primary management method, sustainable alternatives are urgently needed. Sex pheromone communication is critical for moth courtship and mating, with pheromone-binding proteins (PBPs) playing a key role in this process.

ds, a Potential RNA Biopesticide for Controlling by Targeting the Synthesis of Sex Pheromones.

(Hübner) is an important polyphagous agricultural pest that poses a serious threat to global agricultural production. We characterized the pheromone biosynthesis-activating neuropeptide receptor (PBANR) in and elucidated its critical role in sex pheromone biosynthesis and reproduction. Bioinformatic analysis and functional assays confirmed that PBANR is a rhodopsin-like G protein-coupled receptor (GPCR).

Evolutionary origin of the frameshift sites in the ribosomal frameshifting genes of Euplotes.

Background: Programmed ribosome frameshifting is a translational recoding event in which ribosomes slip forward or backward along the mRNA. Although genes utilizing programmed ribosomal frameshifting for their expression have been found in most organisms, such genes are commonly considered rare. However, previous studies indicated that both +1 and +2 ribosomal frameshifting are frequently required for the expression of genes in the ciliates Euplotes.

Role of microbial pesticides in pest control for lepidopteran: research status and prospect.

Lepidoptera has caused huge economic losses to a variety of agricultural and forestry plants. The prevention and control measures of pests and diseases include agricultural, physical, chemical, and biological control. Microbial pesticides (including bacteria, fungi and viruses) were more and more widely used in the prevention and control of lepidopteran pests.

Baculovirus dual-phase infection strategy and biotechnological applications: A structural and regulatory review.

The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) represents a sophisticated baculovirus characterized by a biphasic infection cycle involving budded virions (BV) and occlusion-derived virions (ODV). While BV facilitates systemic spread within hosts, ODV ensures environmental persistence through occlusion bodies. Recent advances in cryo-EM and molecular studies have elucidated the structural intricacies of nucleocapsids, envelopes, and occlusion bodies, revealing roles for proteins like VP39, GP64, and polyhedrin in infection dynamics.

miR-8 modulates immune defense and growth in Arma chinensis Fallou: Implications for pathogen resistance and biocontrol optimization.

Arma chinensis Fallou is a critical biocontrol agent for agricultural pests; nevertheless, its effectiveness is limited by susceptibility to pathogens. The development of artificial diets is anticipated to address this challenge, necessitating a systematic investigation into the physiological and molecular regulatory mechanisms underlying immunity and developmental processes in A. chinensis.

Genome-wide identification of ionotropic receptors and functional analysis of ionotropic co-receptors in Bemisia tabaci.

Background: The sweetpotato whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), is a notorious global pest of tobacco, cotton and many vegetables. The ionotropic receptors (IRs) are an important part of the olfactory system, and the ionotropic co-receptors are essential for many physiological processes in insects.

Results: In this study, we identified 21 IRs and two ionotropic co-receptors, BtIR8a and BtIR25a in sweetpotato whitefly.

AcMNPV, a viral insecticide of Lepidoptera pests, stimulates the immune response of the natural enemy Fallou.

multiple nucleopolyhedrovirus (AcMNPV) is the most widely studied baculovirus currently used as a biopesticide application for crop pest control. AcMNPV has a good control effect on Lepidoptera pests, but the impact of AcMNPV on other insects in the environment, especially natural enemies, is worth further discussion. Fallou, an essential natural enemy insect widely distributed in China, can prey on multiple pests that cause severe damage to the production economy and can play an effective role in preventing agroforestry pests.

Chlorantraniliprole Combined with Wilforine, an Environmentally Friendly and Efficient Chemical Control Strategy for by Regulating Calcium Homeostasis.

poses a significant threat to global food security, having developed resistance to numerous chemical insecticides. Chlorantraniliprole is among the emergency control agents for managing . Wilforine, a plant-derived pesticide, has emerged as a promising candidate for novel pesticide development.

microRNA-34 family: A multifunctional miRNA family.

MicroRNAs are endogenous non-coding small RNAs composed of about 22 nucleotides, which are widely found in eukaryotic cells and regulate gene expression at the post-transcriptional level through complementary pairing with target genes, leading to mRNA degradation or translation inhibition. MiR-34 family is a highly conserved miRNA family during evolution. Recent studies have found that members of the miR-34 family are involved in regulating biological processes such as aging, ciliogenesis, and immunity.

miR-34-5p, a potential RNA biopesticide for controlling Spodoptera frugiperda by targeting of SfEcR and SfE74.

Spodoptera frugiperda is an agricultural pest with strong adaptability and migration ability. For decades, chemical control has been an important technical measure for controlling S. frugiperda.

Orco mediates olfactory behavior and oviposition in the whitefly Bemisia tabaci.

Chemical signals play a central role in mediating insect feeding and reproductive behavior, and serve as the primary drivers of the insect-plant interactions. The detection of chemical signals, particularly host plant volatiles, relies heavily on the insect's complex olfactory system. The Bemisia tabaci cryptic species complex is a group of globally important whitefly pests of agricultural and ornamental crops that have a wide range of host plants, but the molecular mechanism of their host plant recognition is not yet clear.

Cep131-Cep162 and Cby-Fam92 complexes cooperatively maintain Cep290 at the basal body and contribute to ciliogenesis initiation.

Cilia play critical roles in cell signal transduction and organ development. Defects in cilia function result in a variety of genetic disorders. Cep290 is an evolutionarily conserved ciliopathy protein that bridges the ciliary membrane and axoneme at the basal body (BB) and plays critical roles in the initiation of ciliogenesis and TZ assembly.

Comparative genomic analysis of symbiotic and free-living strains provides insights into the evolutionary origins of obligate -bacterial endosymbioses.

Unlabelled: Endosymbiosis is a widespread and important phenomenon requiring diverse model systems. Ciliates are a widespread group of protists that often form symbioses with diverse microorganisms. Endosymbioses between the ciliate and heritable bacterial symbionts are common in nature, and four essential symbionts were described: , " Protistobacter heckmanni," ".

Levodopa Improves Behavioral Deficits of Mice with Parkinson's Disease Symptoms via Curbing NLRP3 Inflammasome Activation and Enhancing Tyrosine Hydroxylase Levels in the Striatum and Substantia Nigra.

Objective: Levodopa (L-DOPA) is the primary treatment for Parkinson's disease (PD). Nevertheless, the underlying mechanism of its action is not entirely learned. This study aims to probe the action of L-DOPA on NLR pyrin domain containing 3 (NLRP3) inflammasome activation and tyrosine hydroxylase (TH) levels in the striatum (STR) and substantia nigra (SN) of mice with PD symptoms.

eIF5A promotes +1 programmed ribosomal frameshifting in Euplotes octocarinatus.

Programmed ribosomal frameshifting (PRF) exists in all branches of life that regulate gene expression at the translational level. The single-celled eukaryote Euplotes exhibit high frequency of PRF. However, the molecular mechanism of modulating Euplotes PRF remains largely unknown.

Diamide insecticides targeting insect ryanodine receptors: Mechanism and application prospect.

As a Lepidoptera pest, Spodoptera frugiperda has become one of the major migratory pests causing significant damage to crops. It should prevent and control Spodoptera frugiperda with strong reproductive ability, adaptability, and migration ability, and reduce economic losses as much as possible. Chemical insecticides are mainly used in the emergency control of Spodoptera frugiperda.

A novel domain-duplicated SlitFAR3 gene involved in sex pheromone biosynthesis in Spodoptera litura.

Fatty acyl reductases (FARs) are key enzymes that participate in sex pheromone biosynthesis by reducing fatty acids to fatty alcohols. Lepidoptera typically harbor numerous FAR gene family members. Although FAR genes are involved in the biosynthesis of sex pheromones in moths, the key FAR gene of Spodoptera litura remains unclear.

me53 encoded by Autographa californica multiple nucleopolyhedrovirus: from mechanism to function.

me53, a highly conserved immediate early gene in all Lepidoptera baculoviruses, has been of great interest in recent years. Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is in the family Baculoviridae, genus Alphabaculovirus. The me53 gene of AcMNPV has been sequenced, and it was transcribed late after infection.

miR-34-5p, encoded by Spodoptera frugiperda, participates in anti-baculovirus by regulating innate immunity in the insect host.

Spodoptera frugiperda is one of the significant migratory pests. Baculovirus, an insect-specific microbial insecticide, has been used to control pests. microRNA-34 (miR-34) regulates insect development and innate immunity to pathogens.

microRNA-34-5p encoded by Spodoptera frugiperda regulates the replication and infection of Autographa californica multiple nucleopolyhedrovirus by targeting odv-e66, ac78 and ie2.

Background: Spodoptera frugiperda is one of the significant migratory pests in the Global Alert issued by the Food and Agriculture Organization of the United Nations. As an insect-specific microbial insecticide, baculovirus has been used to control various pests. MicroRNA-34-5p (miR-34-5p) is involved in regulating growth, reproduction and innate immunity to pathogens in insects, playing an essential role in host-virus interactions.

Recombinant AcMNPV-gp64-EGFP and synergist triphenyl phosphate, an effective combination against Spodoptera frugiperda.

Objectives: AcMNPV is a kind of microbial insecticide that can significantly relieve the resistance of Spodoptera frugiperda to chemical pesticides. TPP is a widely used synergist, which can reduce the use of pesticides by inhibiting carboxylesterase. It is emergently needed to develop a biological control way of Spodoptera frugiperda.

microRNA-34 family: From mechanism to potential applications.

microRNA-34, a highly conserved microRNA in evolution, is of great interest in recent years. miR-34 regulates multiple targets and performed many functions in cells, such as (1) those mediated by targeting ALDH2, Atf1, Bcl-2 have been implicated in cancer cell apoptosis; (2) it targets CCNE2, CDK4, CDK6 and others to regulate the cell cycle; and (3) it regulates immune homeostasis in Drosophila through Dlg1, Eip75B and others. Meanwhile, miR-34 family is a multifunctional miRNA family identified to be pivotal in organ development, organismal or organ senescence, stress response, spermatogenesis and signal transduction.