TabsPBP2, a Pheromone-Binding Protein Highly Expressed in Male Antennae of , Binds Sex Pheromones and Tomato Volatiles.

The tomato leafminer (), a globally invasive pest, poses a major economic threat to tomato production. Although chemical control remains the primary management method, sustainable alternatives are urgently needed. Sex pheromone communication is critical for moth courtship and mating, with pheromone-binding proteins (PBPs) playing a key role in this process.

Advanced Design, Synthesis, and Evaluation of Highly Selective Wee1 Inhibitors: Enhancing Pharmacokinetics and Antitumor Efficacy.

Wee1 is a kinase that regulates cell cycle arrest in response to DNA damage. Wee1 inhibition is a potential strategy to suppress the growth of tumors with defective p53 or DNA repair pathways. However, the development of Wee1 inhibitors faces some challenges.

Distribution of HS in the 10103 excavation working face of the Baozigou coal mine.

Based on the production conditions of the 10103 excavation working face of the Baozigou coal mine, this paper analyzes the potential sources of HS and the expected emission concentrations of HS in the working face. Considering the previous engineering practice for controlling HS disasters in coal mine working faces, numerical simulations were conducted to investigate air flow and HS migration and diffusion in the tunnel in the excavation working face. The migration and distribution of HS in the coal seam mining face were studied, and the effects of outlet wind speed, duct location, and duct diameter on the HS concentration distribution were explored.

Research on the dust-control technology of a double-wall attached-ring air curtain on an excavation face.

On the basis of the jet theory of airflow fields and the gas-solid two-phase flow theory, we studied the law of dust migration in a simulated dusting space. We used the control variable method and numerical simulation software to explore the airflow field and dust concentration distribution on the working surface of the dusting under different inlet wind speeds and different attached blades of the double-walled annular air curtain. We determined the speed of the inlet of the annular air curtain to be 30 m/s.

Molecular Simulation of Coal Molecular Diffusion Properties in Chicheng Coal Mine.

In order to study the importance of the diffusion mechanism of CH and CO in coal for the development of coalbed methane, the aim of this paper is to reveal the influence mechanism of pressure, temperature, water content and other factors on the molecular diffusion behavior of gas at the molecular level. In this paper, non-sticky coal in Chicheng Coal Mine is taken as the research object. Based on the molecular dynamics method (MD) and Monte Carlo (GCMC) method, the diffusion characteristics and microscopic mechanism of CH and CO in coal under different pressures (100 kPa-10 MPa), temperatures (293.

Simulation Study on Molecular Adsorption of Coal in Chicheng Coal Mine.

To study the importance of the adsorption mechanism of methane (CH) and carbon dioxide (CO) in coal for coalbed methane development, we aimed to reveal the influence mechanism of adsorption pressure, temperature, gas properties, water content, and other factors on gas molecular adsorption behavior from the molecular level. In this study, we selected the nonsticky coal in Chicheng Coal Mine as the research object. Based on the coal macromolecular model, we used the molecular dynamics (MD) and Monte Carlo (GCMC) methods to simulate and analyze the conditions of different pressure, temperature, and water content.

Inhibitors of cell cycle checkpoint target Wee1 kinase - a patent review (2003-2022).

Introduction: DNA damage repair in most malignancies with mutation of p53 is more dependent on the G2/M checkpoint. Wee1 kinase is a key regulator of the G2/M checkpoint. If Wee1 is inhibited, it results in cells with unrepaired DNA damage entering mitosis prematurely, leading to mitotic catastrophe and subsequent cell death via the apoptotic program.

Atroposelective Amination of Indoles via Chiral Center Induced Chiral Axis Formation.

The construction of an N-C chiral axis for N-aryl indole derivatives is meaningful as they widely exist in functionalized molecules. This work provides a novel method for this purpose via amination of amino acid derivatives at the C2 position of the indole and chiral center induced chiral axis formation. The protocol of this transformation is easily accessible, not requiring metal or an organic chiral catalyst, endowing this method with great potential in the construction of axis chiral -aryl indoles.

Recent advances in ATM inhibitors as potential therapeutic agents.

ATM, a member of the PIKK-like protein family, plays a central role in responding to DNA double-strand breaks and other lesions to protect the genome against DNA damage. Loss of ATM's kinase function has been shown to increase the sensitivity of most cells to ionizing radiation. Therefore, ATM is thought to be a promising target for chemotherapy as a radiotherapy sensitizer.