Lipid overload meets S-palmitoylation: a metabolic signalling nexus driving cardiovascular and heart disease.

S-palmitoylation has emerged as a critical integrator of lipid overload and cardiovascular dysfunction. Disordered lipid metabolism inundates endothelial cells, vascular smooth muscle cells and macrophages with triglyceriderich lipoproteins, oxidized LDL and saturated fatty acids, expanding the intracellular palmitoylCoA pool and perturbing redox balance. Protein Spalmitoylation, the reversible attachment of palmitate to cysteine residues, converts excess palmitoylCoA into broad alterations in signalling and membrane dynamics.

Significance of Liver Zonation in Hepatocellular Carcinoma.

Liver zonation is fundamental to normal liver function, and numerous studies have investigated the microstructure of normal liver lobules. However, only a few studies have explored the zonation signature in hepatocellular carcinoma (HCC). In this study, we investigated the significance of liver zonation in HCC with the help of single-cell RNA sequencing (scRNA-seq) and multicolor immunofluorescence staining.

Non-destructive classification of apple bruising time based on visible and near-infrared hyperspectral imaging.

Background: Bruising time of apple is one of the most important factors for internal quality assessment. The present study aimed to establish a non-destructive method for the classification of apple bruising time using visible and near-infrared (VNIR) hyperspectral imaging. In this study, VNIR hyperspectral images were obtained and analyzed at seven bruising periods.